DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tyn and nompA

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_524831.2	Gene:	nompA / 45587	FlyBaseID:	FBgn0016047	Length:	1557	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	137/567 - (24%)
Similarity:	211/567 - (37%)	Gaps:	142/567 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 PAQACKNNRSFGNSQKMGVSEEKVAQYVGLHYYTDKELQVTSESACRLACEIESEFLCRSFLYLG 279
            |...|:.:.:|         ::..|::....::..:.|.|.|...|...|....:|:||||.| .
  Fly   907 PITRCEESDNF---------KQIAARHKMRRHFVRRALIVPSLIQCERECIESRDFVCRSFNY-R 961

  Fly   280 QPQGSQYNCRLYHLDHKTLPDGPSTYLN--HERPLIDHGEPIGQYFENQCEKAAGLGAGSPPGTL 342
            ....|.|..|    |.....|.|:..|:  ..|.|..|                      .|||.
  Fly   962 DSAASGYEDR----DRDRDRDSPNCELSDRDSRELDIH----------------------DPGTF 1000

  Fly   343 DKIDTLPVSLDTIEDPNLTNLTRNDVNCDKTGTCYDVSVHCKDTRIAVQVRTNKPFNGRIYALGR 407
            |     ..:.|..|    .::.|:|      |.|.||:..|.:..:...:||.:.|.||||..|.
  Fly  1001 D-----ASNYDFYE----RSIGRSD------GECMDVTQTCNEEGMEFTIRTPEGFLGRIYTYGF 1050

  Fly   408 SETC----NIDVINSDAFRLDLTMAGQDCNTQSVTGVYSNTVVLQHHSVVMTKADKIYKVKCTYD 468
            .:.|    |...:|  ..||.......||.||......:|.||:|....|.|..||.|.:.|.:
  Fly  1051 YDRCFFRGNGGTVN--VLRLSGPQGYPDCGTQRYGDTLTNIVVVQFSDNVQTSRDKRYNLTCIF- 1112

  Fly   469 MSSKNITFGMMPIRDP-EMI----HINSSPEAPPP--------------RIRILDTRQREVETVR 514
                         |.| |.:    :|.:...:|.|              |:.|| .:.|...|:.
  Fly  1113 -------------RGPGEAVVSSGYIGAGSGSPIPIEYLPAENTLSSKVRLSIL-YQGRPTTTIA 1163

  Fly   515 IGDRLNFRIEIPEDTPY--GIFARSCVAMAKDARTSFKIIDDDGCPTDPTIFPGF--TADGNALQ 575
            :||.|.||:|..:...:  .|||.:.||....:..|.::||..|||.||.:||..  ..||:.|:
  Fly  1164 VGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQLIDRFGCPVDPFVFPELDKLRDGDTLE 1228

  Fly   576 STYEAFRFTESYGVIFQCNVKYCLGPCEPAVCEWNMDSFESLGRRRRRSIESNDT---------- 630
            :.:.||:..||..::|:..|:.|...|:||.|.......|....|||||:.:.:.
  Fly  1229 ARFNAFKIPESNFLVFEATVRSCREGCQPAYCPGPAGRQEPSFGRRRRSLNTTEIPEPEALALEG 1293

  Fly   631 KSEDDMNISQEILVLD-----------------FGDEKREFFKADPSTDFAK------------- 665
            .|:.:.:...|:.|::                 .|::.:|..:.:...:..:
  Fly  1294 SSQLEASTLDEVTVVNSTTVSATLGQVPLNETQLGEKTKETEEPEQVREMIEVFETREEIEKESY 1358

  Fly   666 -DKTVTIIEP-CPTKTSVLAL-AVTCALMILLYISTLFC--YYMKKW 707
             .|.|..:|. |.|......| .....|||||:..||..  .|.:.|
  Fly  1359 PRKLVAPVETVCMTPAEYHGLITAIILLMILLFSITLVAGLGYRRYW 1405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052
		PAN_AP_HGF	131..210	CDD:238532
		PAN_1	236..327	CDD:394981	22/92 (24%)
		ZP	382..598	CDD:214579	69/242 (29%)
nompA	NP_524831.2	PAN_AP_HGF	150..231	CDD:238532
		PAN_AP_HGF	244..>303	CDD:238532
		PAN_AP_HGF	349..424	CDD:238532
		PAN_AP_HGF	914..1011	CDD:238532	29/141 (21%)
		ZP	1025..1264	CDD:214579	74/255 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D200714at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920