DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tyn and nyo

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_651871.2	Gene:	nyo / 43716	FlyBaseID:	FBgn0039852	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	187/745 - (25%)
Similarity:	285/745 - (38%)	Gaps:	203/745 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LPEQINARM-AFEKLTDF----------DFPGNTYYSVKNLSLYECQGWCREEADCQAAAFSFVV 83
            |.|:.:..| .||.:|.:          ..||       .|.|.:|...|:....|.|..:
  Fly   110 LEEECDPDMIGFEIITGYVLSAPSKMLDTLPG-------TLMLTDCLEACQSNESCSAVNY---- 163

  Fly    84 NPLSPSQETH-CQLQNDSSAANPSAAPQRSANMYYMIKLQLRSENV--CHRPWSFERVPN----K 141
                   ||. |.|...::...|.:. .||....:.|..|.....|  |.:.|..:||..    :
  Fly   164 -------ETGLCVLFKTTADKLPGSL-SRSQFPVFTIYAQKSCLGVRPCSKAWCIDRVQGYRLPE 220

  Fly   142 VIRGLDNALIYTSTKEACLSACLNERRFVCRSVEYDYNNMKCVLSDSDR--RSSGQFVQLVDAQG 204
            .::.....|    ::..||..||.|..|.|||..|..::..|.|||.||  .|:|..|:..|  |
  Fly   221 HVKSSQTVL----SRRDCLELCLGETEFTCRSANYYRHSGLCELSDMDRITLSAGGSVEPYD--G 279

  Fly   205 TDYFENLCL-KPAQACKNNRSFGNSQKMGVSEEKVAQYVGLHYYTDKELQVTSESACRLACEIES 268
            .||.||.|. :|::.|:..|..|          |:.:.|...|   :::....|  ||..| :.|
  Fly   280 ADYLENNCAEEPSKLCEFKRISG----------KILKTVDSVY---QDINTIDE--CRDLC-LNS 328

  Fly   269 EFLCRSFLYLGQPQGSQYN------CRLYHLDHKTLPDGPSTYLNHERPLIDHGEPIGQYFENQC 327
            .:.|.|:         .||      |||.|....||.|....||:         .|....:|
  Fly   329 PYRCHSY---------DYNDTGDMVCRLSHHSRATLTDVMDPYLD---------VPEAATYE--- 372

  Fly   328 EKAAGLGAGSPPGTLDKIDTLPVSLDTIEDPNLTNLTRNDVNCDKTGTCYDVSVHCKDTRIAVQV 392
                                                         ...||:||:.|:...:..::
  Fly   373 ---------------------------------------------LSACYNVSIECRSGEMITKI 392

  Fly   393 RTNKPFNGRIYALGRSETCNIDVINSDAFRLDLTMAGQDCNT-QSVTGVYSNTVVLQHHSVVMTK 456
            ||:|.|:|::||.|..::|.::|.||..|...:.....:||. ||..|.|.|.:|:|||.:::|.
  Fly   393 RTSKLFDGKVYAKGAPKSCAVNVNNSLEFDFRMGYNDLECNVRQSAYGRYMNDIVIQHHDMIVTS 457

  Fly   457 ADKIYKVKCTYDMSSKNI-------TFGMMPIRDPEMIHINSSPEAPPPRIRILDTRQREVETVR 514
            :|....|.|.||:::|.:       ..|.:.....|.|.|:|      |.: |:....|:...::
  Fly   458 SDLGLAVSCQYDLTNKTVLNDVDLGVTGEIESSLSEEITIDS------PNV-IMKITSRDGSDMK 515

  Fly   515 ----IGDRLNFRIEIPE-DTPYGIFARSCVAMAKDARTSFKIIDDDGCPTDPTI---FPGFTADG 571
                :||.|..|.||.| ::||.||.|..|||.........:||.:|||||..|   ......:.
  Fly   516 RMAEVGDPLALRFEIVEPNSPYEIFVRELVAMDGSDSAEITLIDANGCPTDQYIMGTIQKLAQNR 580

  Fly   572 NALQSTYEAFRFTESYGVIFQCNVKYCLGPCEPAVCE------WNMDSFESLGRRRRRSIESNDT 630
            ..|.|.::||:|..|..|.|:..|..|:..|||.:|:      ..:.|..|.||::|..:...|.
  Fly   581 KVLLSQFDAFKFPSSEVVQFRALVTPCIPRCEPVICDSEDGASGELKSLVSYGRKKRSVLNGTDG 645

  Fly   631 KS--------------EDDMNISQEILVLD-FGDEKREFFKADPSTDFAKDKTVTIIEPCPTKTS 680
            ..              :|::.:.|.|.:.| ||     |...|.:|....|..       |.:.:
  Fly   646 AEFLISTRHRRDVGPVDDNILLMQSIQITDKFG-----FQPEDGTTTHGNDSG-------PHEKA 698

  Fly   681 VLALA---VTC----------ALMILLYIS 697
            ...:|   :||          ||.:|..:|
  Fly   699 YAGVAQDKLTCLNGYGLIMAGALFLLAQLS 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	11/61 (18%)
		PAN_AP_HGF	131..210	CDD:238532	27/84 (32%)
		PAN_1	236..327	CDD:394981	23/96 (24%)
		ZP	382..598	CDD:214579	72/231 (31%)
nyo	NP_651871.2	PAN_1	121..198	CDD:278453	20/95 (21%)
		PAN_AP_HGF	208..286	CDD:238532	28/83 (34%)
		PAN_1	295..374	CDD:278453	26/160 (16%)
		ZP	382..618	CDD:214579	77/242 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
	5	4.840