DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tyn and MATN3

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_002372.1	Gene:	MATN3 / 4148	HGNCID:	6909	Length:	486	Species:	Homo sapiens

Alignment Length:	356	Identity:	63/356 - (17%)
Similarity:	101/356 - (28%)	Gaps:	134/356 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MAFEKLTDFDFPGNTYYSVKNLS----------------LYECQGWCREEADCQAAAFSFVVNPL 86
            ||.|.|.:..|...||..::.||                .::||..|..:.:
Human   233 MASEPLEEHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGE------------- 284

  Fly    87 SPSQETHCQLQNDSSAANPSAAPQRSANMYYMIKLQLRSENVCHRPWSFERVPNKVIRGLDNALI 151
               .:.||:                                 |.:.::. ....|....||...:
Human   285 ---GKHHCE---------------------------------CSQGYTL-NADKKTCSALDRCAL 312

  Fly   152 YTSTKEACLSACLNER--RFVCRSVE-YDYNNMKCVLSDSDRRSSG----QFVQLVDAQGTDYFE 209
            .|   ..|...|:|:|  .:.|...| |..|..:...|..|:.:.|    |.:.:.|..|:.:.|
Human   313 NT---HGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCE 374

  Fly   210 NLCLKPAQACKNNRSFGNSQKMGVSEEKVAQYVGLHYYTDKELQVTSESACRLACEIESEFLCRS 274
                     |....:....:|.....:|.|  :|.|             .|:..|..:.
Human   375 ---------CYEGYTLNADKKTCSVRDKCA--LGSH-------------GCQHICVSDG------ 409

  Fly   275 FLYLGQPQGSQYNCRLYHLDHKTLPDGPSTYLNHERPLIDHGEPIGQYFENQCEKAAGLGAGSPP 339
                    .:.|:|..|          |...||.::......|...:....  |.|.|..|
Human   410 --------AASYHCDCY----------PGYTLNEDKKTCSATEEARRLVST--EDACGCEA---- 450

  Fly   340 GTL---DKIDTLPVSLDTIEDPNLTNLTRND 367
             ||   ||:.:....|:|..|..|..|..|:
Human   451 -TLAFQDKVSSYLQRLNTKLDDILEKLKINE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	10/66 (15%)
		PAN_AP_HGF	131..210	CDD:238532	18/85 (21%)
		PAN_1	236..327	CDD:394981	13/90 (14%)
		ZP	382..598	CDD:214579
MATN3	NP_002372.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..75
		vWFA	80..303	CDD:320736	15/119 (13%)
		FXa_inhibition	310..346	CDD:317114	9/38 (24%)
		FXa_inhibition	352..388	CDD:317114	7/44 (16%)
		FXa_inhibition	394..430	CDD:317114	11/74 (15%)
		Matrilin_ccoil	441..483	CDD:313592	14/47 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000