DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tyn and sle

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_731472.1	Gene:	sle / 41262	FlyBaseID:	FBgn0037810	Length:	1430	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	130/745 - (17%)
Similarity:	231/745 - (31%)	Gaps:	271/745 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SPSQETH-CQLQ-NDSSAANPSAAPQRSANMYYMIKLQLRSENVCHRPWSFERVPNKVIRGLDNA 149
            |||.|.| .::| ||.|:.|.:..|:..:|.         |.|...               |..|
  Fly   752 SPSDEEHDGKVQSNDDSSENKTEKPKNQSNC---------SSNASK---------------LSEA 792

  Fly   150 --LIYTSTKEACLS---------ACLNE----RRFVCRSVEYDYNNMKCVLSDSDRRSSGQFVQL 199
              |:..|.:::.:|         ..|||    .||.....:.|.:.|:...||.|.....:.|
  Fly   793 AQLLNVSEEKSSISETELERSRQVALNELNKSERFNKTETQLDISVMEVDSSDHDEEEKTEKV-- 855

  Fly   200 VDAQGTDYFENLCLKPAQACKNNRSF--------GNSQKMGVSEEKVAQYVGLHYYTDKELQVTS 256
                              ..|||||.        |..|....|:            .||..:..:
  Fly   856 ------------------GAKNNRSLYEIVDSDDGEEQDQDQSD------------ADKPAESEN 890

  Fly   257 ESACRLACEIESEFLCRSFLYLGQPQGSQYNCRLYH-LDHKTLPDGPSTYLNHERPLIDHGEPIG 320
            .|      ||:     :|..::.|..|::.|..:|. :|.....|......|.|.   |..:|..
  Fly   891 HS------EIK-----KSTSFMDQMSGAKGNKSVYEIMDSYETEDPKEAGKNEES---DKDKPAE 941

  Fly   321 QYFENQCEKA-AGLGAGSPPGTLDKIDTLPVSLDTIEDPN--LTNLTRNDVN--------CDKTG 374
            ....::.::| ..:.....|..:....|:..|:.:..|..  |..|..:|::        ..|:.
  Fly   942 NGKSDKDKQAETEMSDEDKPSEIKSPSTIKKSIISTADEEALLAELASSDLSHLEKMFNPLQKSR 1006

  Fly   375 TCYDVSVHCKDTRIAVQVRTNKPFNGRIYALGRSETCNI--DVINSDAF---------------R 422
            .   .|:|.....:|.:       |.::..  |||...:  |...|.:|               |
  Fly  1007 R---QSLHVPSPELAAK-------NPKLRR--RSERVEVGNDFCPSQSFVDMVAEKKRQKNKRKR 1059

  Fly   423 LDLTMAG--QDCNTQSVT----------GVYSNTVVLQHHSVVMTKADKIYKVKCTYDMSSKNIT 475
            |..:::|  :|.....:.          |..::::...:.:..||.|::.:        |...::
  Fly  1060 LSKSLSGAPEDLEEMEIKHERKRLKSSHGASTDSMEEDNENETMTVAEEHH--------SDGEVS 1116

  Fly   476 FGMMPIRDPEMIHINSSPEAPPPRIRILDTRQREVETVRIGDRLNFRIEIPE--DTP-------- 530
            .|.:||.:..    .:|.|.|.     ......|.|||.:.:.|   :|.|:  |:|
  Fly  1117 NGEVPIEEKP----TTSSEKPS-----ASELPEEEETVAVEELL---MEKPKTCDSPRSEERPTE 1169

  Fly   531 --------------------YGIFARSCVAMAKDAR-----------------------TSFKII 552
                                |..:..:.:..|.:|:                       ...|::
  Fly  1170 IVTSKPKGMAPVKVEKTAEYYLAYCHNLLEAANEAKLKEKKEHLASGAKQKKPKRIAAQAPSKLL 1234

  Fly   553 DDDGCPTDPTIF------PGFTADGNALQSTYEAFRFTESYGVIFQCNVKYC----------LGP 601
            ...|..::....      |....|...||:..:|.    |:.|......|..          |.|
  Fly  1235 GTIGSESETNTAKSSKQPPALKKDVKRLQAARQAV----SHAVNLLAPPKATEAEPRTLSRKLSP 1295

  Fly   602 CEPAVCEWNMDSFESLGRRRRRSIESNDTKSEDDMNISQEILVLDFGDEKREFFKADPSTDFAKD 666
            ..|.|.:  ..:.:..|:::::..|::..||.|:.|....|
  Fly  1296 QPPVVDK--KSAKQKKGKKKQKPQEASPLKSSDEENHGHRI------------------------ 1334

  Fly   667 KT----VTIIEPCPTKTSVLALAVTCALMI 692
            :|    ||:::..|||...:.|..|.:.|:
  Fly  1335 RTNAGYVTVVDEPPTKVPKIELIKTSSGMV 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	5/10 (50%)
		PAN_AP_HGF	131..210	CDD:238532	16/93 (17%)
		PAN_1	236..327	CDD:394981	16/91 (18%)
		ZP	382..598	CDD:214579	46/303 (15%)
sle	NP_731472.1	MDN1	<289..716	CDD:227596
sle	NP_731472.1	MDN1	<685..960	CDD:227596	55/277 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900