DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tyn and cutl-8

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001250721.1	Gene:	cutl-8 / 3565740	WormBaseID:	WBGene00013960	Length:	625	Species:	Caenorhabditis elegans

Alignment Length:	289	Identity:	83/289 - (28%)
Similarity:	125/289 - (43%)	Gaps:	57/289 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 VHCKDTRIAVQVRTNKPFNGRIYALGRS--ETCNIDVINSDAFR---LDLTMAGQDCNTQSVTGV 440
            :.|.:..|.:.|:|.|.|.|||||.||:  |.|..|...:...|   .||....  |..:|:..|
Worm    32 IECLEDEIRIWVKTRKIFAGRIYAKGRAELEDCYKDDFGNQKTRKPHFDLQFGA--CGMKSLRSV 94

  Fly   441 ------YSNTVVLQHHSVVMTKADKIYKVKCTYDMSSKNIT----FGMMPIRDPEMIH------- 488
                  |..|||:..|.:.:||.|:.|.|||.::.::|.:|    ..|:|..:.|..|
Worm    95 DPRGMYYGITVVVSFHPLFITKVDQAYHVKCFFEEANKGLTAELGVSMIPTTELEARHGIPGCTY 159

  Fly   489 -INSSPEAPPPRIRILDTRQ---REVETVRIGDRLNFRIEIPEDTPYGIFARSCV---AMAKDAR 546
             |:.|      .|..||..:   ..::..|:|:|:..:... .|..||:...:|.   ...|.|
Worm   160 SIHRS------TIDELDAGRPAGNVIQFARVGERVLHQWHC-NDQMYGVLINNCYVTDGFGKKA- 216

  Fly   547 TSFKIIDDDGCPTDPTIFPG--FTADGNALQSTY---EAFRFTESYGVIFQCNVKYCL---GPCE 603
               .:|||.|||.||.:..|  :::|   ||..|   ..|:|.:..||.|.|.|:.|:   |.|:
Worm   217 ---DVIDDKGCPIDPILITGIRYSSD---LQRAYAESSVFKFADKPGVWFFCQVQMCMKKHGMCD 275

  Fly   604 ---PAVCEWNMDSFESLGRRRRRSIESND 629
               |..| .:|....|:|.......|..:
Worm   276 GITPPSC-GSMSRVISVGGEDNGGFEEEE 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052
		PAN_AP_HGF	131..210	CDD:238532
		PAN_1	236..327	CDD:394981
		ZP	382..598	CDD:214579	74/249 (30%)
cutl-8	NP_001250721.1	ZP	33..285	CDD:214579	79/268 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D200714at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920