DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tyn and cutl-17

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001379101.1	Gene:	cutl-17 / 185474	WormBaseID:	WBGene00009541	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	864	Identity:	171/864 - (19%)
Similarity:	288/864 - (33%)	Gaps:	275/864 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VKNLSLYECQGWCREEADC-QAAAFSFVVNPLSPSQETHCQLQNDSSAANPSAAPQRSANMYYMI 119
            :|:::|.||...|...... :..:|.:..:.|..|..:     :|......|...:.|..:.:..
Worm    44 MKDVTLNECANACSNSLSTEECLSFEYDASILQCSHHS-----DDGQPFGASVLAKASQTISFFQ 103

  Fly   120 KLQLRSENVCHRPWSFERVPNKVIRGLDNALIYTSTKEACLSACLNERR---FVCRSVEYDYNNM 181
            ::.|..|.||..|:||||.|..::.|....::.......|||.|...:|   |:|:|..|.|...
Worm   104 QICLLEEAVCKAPYSFERYPQSILIGHAMKVLTVDGLSDCLSKCALSQRSYDFLCKSAIYYYETG 168

  Fly   182 KCVLSDSDRRSSGQFV-------QLVDAQGTDYFENLCLKPAQACKNNRSFGNSQKMGVSEEKVA 239
            :|:::..::     |:       .::|.. .|||||.|..  .:||              .|:..
Worm   169 ECIMNRDNK-----FIYPKLFKTNILDTL-VDYFENNCAD--VSCK--------------PEETL 211

  Fly   240 QYVGL-HYYTDKELQVTSESA----CRLACEI----ESEFLCRSFLYLGQPQGSQYNCRLYHLDH 295
            .:|.. .|..|:...|..||:    |...|:.    |..|.|::|.|    ..|:..|.|
Worm   212 HWVRTEEYLIDESKDVIVESSDAQECNQLCQNNKIGEENFPCKAFAY----SNSKQECHL----- 267

  Fly   296 KTLPDGPSTYLNHERPLIDHGEPI--GQYFENQC------------------------------- 327
                ...|:|:.|:.....:..|:  |:|||..|
Worm   268 ----TAESSYVGHKGDKRFNLAPLNSGEYFEKYCLPTNLQCIEASFELVANRMMTSAYKTISALS 328

  Fly   328 -----EKAAGLGAGSPPGT------------------------------LDKI----DTLPVSLD 353
                 .:....||.....|                              .|||    |..|: |.
Worm   329 QHECLSQCMNDGARCSSATYFYMDDECQLSDISQFSRPNEFVVANFTDYFDKICDPADPKPM-LT 392

  Fly   354 TIEDPNLTNLTRNDVNCDK------------------TGTCYD---------------------- 378
            |.|.|  ..|.:|.|:.::                  |||..:
Worm   393 TPETP--PELIQNSVDEEETTSERSIAQGAANFEVATTGTSVEFEDDNLLKDNQAVDAVHGVTTT 455

  Fly   379 --------------------------------------------------VSVHCKDTRIAVQVR 393
                                                              :|..|:.:.|:|.::
Worm   456 TNIGEKRETKVEIEETVIDDADEFSREIDDSHEESPLTSSEESEGRVKARLSTECRMSGISVSLK 520

  Fly   394 TNKPFNGRIYALGRSETCNIDVINSDAFRLDLTMAGQD---C-NTQSVTGVYSNTVVLQHH---- 450
            ...|.:|.||......:|.....|:....|.:....:|   | ..:|....:...||::.:
Worm   521 FATPTSGTIYIKDHFSSCRQSFSNTSFAELHIPFPTEDDSKCGGIESEPHKWDYNVVVERNDMKT 585

  Fly   451 -SVVMTKADKIYKVKCTYD-MSSKNITFGMMPIRDPEMIHINSSPEAPPPRIRILDTRQREVETV 513
             |:|.|| ||.::|.|.:. ::.||....:.|       .:....::....:.|:...| .|.||
Worm   586 PSLVTTK-DKTFQVSCDFSKIADKNQLAALKP-------KVEGDVKSEKVLMEIVRNGQ-AVTTV 641

  Fly   514 RIGDRLNFRIEIPEDT-PYGIFARSCVAMAKDARTSF----KIIDDDGCPT---------DPTIF 564
            .:|..::.|..:.::| ..|.|...|:|.....:..:    ||| ..|||.         ||.:
Worm   642 PLGAEVSLRWTVIDETDKLGFFINECIAERVGGQPPYPEPLKII-YQGCPEEKVRNRLLHDPVV- 704

  Fly   565 PGFTADGNALQSTYEAFRFTESYGVIFQCNVKYCLGPCEPAVCE----WNMDSFESLGRRRRRSI 625
                .:|....:..:.|||..|..|..:|::..|:..|.|.:|:    .|:|||   ||::|.|.
Worm   705 ----KNGEVYSTKMKVFRFDGSRRVRIKCSIDVCVEKCPPVICDDLEIRNVDSF---GRKKRNSN 762

  Fly   626 ESNDTKSEDDMNISQEILV---LDFGDEKREFFKADPSTDFAKDKTVTIIEP-CPTKTSVLALAV 686
            .....|:.:.....:..:|   |...||:.......|..:|:...:.:..:. |..|..:..|.|
Worm   763 VEKWLKAGNKKETRKRRMVTGTLTITDEEETNTTVKPRPEFSTSSSSSSQQQYCVQKDRIEFLIV 827

  Fly   687 TCALMILLYISTLFCYYMK 705
            ...|:|||.|.....:|.|
Worm   828 IVVLLILLQIGLALFFYRK 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	8/41 (20%)
		PAN_AP_HGF	131..210	CDD:238532	23/88 (26%)
		PAN_1	236..327	CDD:394981	25/101 (25%)
		ZP	382..598	CDD:214579	53/239 (22%)
cutl-17	NP_001379101.1	PAN_1	26..106	CDD:394981	11/66 (17%)
		PAN_AP_HGF	114..199	CDD:238532	24/90 (27%)
		PAN_AP	208..295	CDD:214680	24/99 (24%)
		PAN_AP_HGF	308..380	CDD:238532	3/71 (4%)
		Zona_pellucida	509..744	CDD:421542	56/249 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I3142
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D200714at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.960