DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tyn and cutl-27

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_502252.3	Gene:	cutl-27 / 183003	WormBaseID:	WBGene00007802	Length:	969	Species:	Caenorhabditis elegans

Alignment Length:	762	Identity:	150/762 - (19%)
Similarity:	242/762 - (31%)	Gaps:	225/762 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NARMAFEKLTDFDFPG-NTYYSVKNLSLYECQGWCREEAD--CQAAAFSFVVNPLSPSQETHCQL 96
            |.|:.|......|.|. .....||  |:..|...|.....  |::..|....|....|.||
Worm   228 NGRIEFVVTRKADVPSFGISLGVK--SIRSCMQACVNAGQFYCRSVQFDSTSNECFVSDET---- 286

  Fly    97 QNDSSAANPSAAPQRSANMYYMIKLQLRSENVCHRPWSFER------VPNKVIRGLDNALIYTST 155
                   :..|.|..|.::.....:....||.|:||:|||:      |.:.:|:.:.|     .:
Worm   287 -------SDVAVPSTSLDILEPFCVPRSDENTCNRPYSFEKMITSKLVNSSIIKEITN-----QS 339

  Fly   156 KEACLSACLNERRFVCRSVEYDYNNMKCVLSDSD------------------------------- 189
            .|.||..|::...  |:||.|:.....|:||.:.
Worm   340 TEKCLQKCIDMEN--CKSVNYNVLTRSCLLSSTSKSISATVSDENYDFYERSCPYIPTSPTSSSS 402

  Fly   190 ----------------------RRSSGQFVQLVDAQGTDYFENLCLKPAQAC------------- 219
                                  |:.|.:||...:.:......:||:.....|
Worm   403 FIPHPPTLYPEVVTRYKLMERGRQLSSEFVNKTNVENVQDCWSLCVNSKVHCELISFSTTSNQCL 467

  Fly   220 ----KNNRSFGNSQKMGVSEEKVAQYVGLHYYTDKELQVTSESACRLACEIESEFLCRSFLYLGQ 280
                |::.:..:|:|:....|....|          ....|.|...:...|.|....|...|...
Worm   468 LSTLKSSETASDSKKITKPSETFDTY----------SSSVSVSTTHVPTSIRSTSSARPTTYSTT 522

  Fly   281 PQGSQYNCRLYHLDHKTLPDGPST--YLNHERPLIDHGEPIGQYF----------ENQCEKAAGL 333
            .:.|...     :...|..||.|:  .|.....:.|    |.:.|          .::.......
Worm   523 VKSSTTT-----VSTSTRHDGSSSSESLEDMNDIFD----INENFMDTTMTSSSTRSRAHALPNA 578

  Fly   334 GAGSPPGTLDKIDTLPVSLDTIEDPNLTNLTRNDVNCDKT--------GTCY------DVSVHC- 383
            ...|...:.:....||:      ||.|..|.      |.|        |..:      .::..|
Worm   579 ETKSSNKSSESTSLLPI------DPELVGLE------DSTPIQLPLNSGIAHVDLSRLSIAAQCL 631

  Fly   384 -KDTRIAVQVRTNKPFNGRIYALGRSETCNIDVINSDAFRLDLTMAGQD--CNTQSVTGVYSNTV 445
             :...|...:..|..:.|.:||..|.:.|.:.|.||.||.:.:.....:  ||...:....|..:
Worm   632 PQGINITFDLTQNTKYTGVVYASERFDQCRVFVKNSSAFSIFIPRPKHNSWCNAVELNNEMSTII 696

  Fly   446 VLQHHSV----VMTKADKIYKVKCTYDMS-----SKNITF-GMMPIRDPEMIHINSSPEAPPPRI 500
            ::.:..:    |.||.|..|:|.|.|:.:     ||.|.. |..|:...:..||:.       :|
Worm   697 IMSNDRILPHDVTTKDDLFYQVSCQYNPNDDAKVSKGIVVGGPSPVMITKKSHIHE-------KI 754

  Fly   501 RILDTRQRE-VETVRIGDRL------NFRIEIPEDTPYGIFARSCVAM---AKDARTSFKIIDDD 555
            .:..|:..: ||:|.:|:.|      |...|:       :....|.|.   ......|..:| .|
Worm   755 SLEITKDGQMVESVFVGESLLATVKSNVSAEL-------LRIVDCTAHRVGGTGPPASVNLI-AD 811

  Fly   556 GCPTDPTIFPGFTADGNALQSTYEAFRFTESYGVIFQCNVKYC-------LGPC-EPAVCEWNMD 612
            ||...|.|........:..||:..|||...|..:...|.:..|       |..| .||
Worm   812 GCALLPAIMSPMRLTPSGWQSSLSAFRIDGSEQIDVVCIISICDENKKCPLMACTSPA------- 869

  Fly   613 SFESLGRRRRRSIESNDTKSEDDMNISQEILVLDFGDE----KREFF 655
                   .|.|.:.|  |..|:.:.:.:.:||.  ||:    .::||
Worm   870 -------NREREVRS--TSEENSIRVDRRLLVK--GDKNYAGSQKFF 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	13/53 (25%)
		PAN_AP_HGF	131..210	CDD:238532	23/137 (17%)
		PAN_1	236..327	CDD:394981	17/102 (17%)
		ZP	382..598	CDD:214579	56/239 (23%)
cutl-27	NP_502252.3	PAN_1	148..219	CDD:278453
		PAN_AP_HGF	235..>287	CDD:238532	13/64 (20%)
		PAN_AP_HGF	313..389	CDD:238532	19/82 (23%)
		PAN_1	423..493	CDD:278453	11/69 (16%)
		ZP	629..867	CDD:214579	59/252 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D200714at33208
OrthoFinder	1	1.000	-	-		FOG0012727
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020