DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tyn and noah-2

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_502699.1	Gene:	noah-2 / 178365	WormBaseID:	WBGene00009926	Length:	741	Species:	Caenorhabditis elegans

Alignment Length:	749	Identity:	193/749 - (25%)
Similarity:	292/749 - (38%)	Gaps:	192/749 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 CQGWCREE------ADCQAAAFSFVVNPLSPSQETHCQLQNDSSAANPSAAPQ----RSANMYYM 118
            |..:||..      |....|:|:|      ..:|| |...:|  ||.|:...|    .|||.:|.
Worm    53 CAQYCRNNIEPTTGAQRVCASFNF------DGRET-CYFFDD--AATPAGTSQLTANPSANNFYY 108

  Fly   119 IKL---QLRSENVC-HRPWSFERVPNKVIRGLDNALIYTSTKEACLSACLNERRFVCRSVEYDYN 179
            .|.   .:.:...| :|.:||||..|..:.|.....:....:|.||||||.|:.|||:||.:.|:
Worm   109 EKTCIPNVSAHEACTYRSFSFERARNTQLEGFVKKSVTVENREHCLSACLKEKEFVCKSVNFHYD 173

  Fly   180 NMKCVLSDSDRRSSGQFVQLVDAQGTDYFENLCLKPAQACKNNRSFGNSQKMGVSEEKVAQYVGL 244
            ...|.||..|:||....|::  ::..||::|.||.....|  ..|.||...:..:..::
Worm   174 TSLCELSVEDKRSKPTHVRM--SEKIDYYDNNCLSRQNRC--GPSGGNLVFVKTTNFEI------ 228

  Fly   245 HYYTDKELQVTSESACRLACEIESEFLCRSFLYLGQPQGSQYNCRLYHLDHKTLPDGPSTYLNHE 309
            .||...:.....||.|...|.......|||..:  .|:  :.||.:...|..:..|
Worm   229 RYYDHTQSVEAQESYCLQKCLDSLNTFCRSVEF--NPK--EKNCIVSDEDTFSRAD--------- 280

  Fly   310 RPLIDHGEPIGQ-YFENQC-----------EKAA----------GLGAGSPPGTLDKIDTLPVSL 352
                ..|:.:|: |:|..|           ::||          |....|..|.
Worm   281 ----QQGQVVGKDYYEPICVAADLSSSTCRQQAAFERFIGSSIEGEVVASAQGV----------- 330

  Fly   353 DTIED---PNLTNLTRNDVNCDKT-GTCYDVSVHCKDTRIAVQ---------------------- 391
             ||.|   ....||....:|.|:| .:|:..:|..:|..|...
Worm   331 -TISDCISLCFQNLNCKSINYDRTASSCFIYAVGRQDANIKANPSMDYYEFNCESQFGGMALCTN 394

  Fly   392 ------VRTNKPFNGRIYALGRSETCNIDVINSDAFRLDLTM----AGQDCNTQSVTG------V 440
                  |.|.:|:.|.|||..|..||:..|.|  |.::.:|.    ...||.|....|      |
Worm   395 EGIRFIVNTKEPYTGAIYAAERFSTCSQVVEN--AKQISITFPPPTVSSDCGTVIRDGKMEALVV 457

  Fly   441 YSNTVVLQHHSVVMTKADKIYKVKC-----------------TYDMSSKNITFGMMPIRDPEMIH 488
            .|...||.|.  |.|:.|:.|:|.|                 .|:.||:|.|     :.|
Worm   458 VSLDGVLPHQ--VTTEWDRFYRVSCDVSMDKMVKEGSVVVTTIYEASSQNTT-----VLD----- 510

  Fly   489 INSSPEAPPP---RIRILDTRQREVETVRIGDRLNFRIEIPEDTPYGIFARSCVAMAKDA---RT 547
                ...|||   .::||:..:..:....|||.|...|...:..|:.:....|.|.....   ..
Worm   511 ----VATPPPVSAELQILNQLEEPLHKASIGDPLLLVITSEQAGPHNMMVTECTATRVGGFGDTV 571

  Fly   548 SFKIIDDDGCPTDPTIFPGFTA--DGNALQSTYEAFRFTESYGVIFQCNVKYCLGP--CEPAVCE 608
            .|.:| ::|||..|.:......  |.|.|:|...|||...||.|...|::.:|.||  |..:.|
Worm   572 PFTLI-ENGCPRYPALVGPVEQDFDKNRLKSDLRAFRLDGSYDVQIVCSIMFCAGPNGCPVSNC- 634

  Fly   609 WNMDS-----FESLGRRRRRS-IESNDTKSEDDMNISQEILVLDFGDEKREFFKADPS--TDFAK 665
              :||     |.|.||::|.: :|:.:|:.:    :|..|.|...|:::.|...|:.:  |..:
Worm   635 --LDSGTNELFMSHGRKKRSADLEAGETEEK----LSAIIRVFAKGEDEEEMEMANNTMMTSMS- 692

  Fly   666 DKT--VTIIEPCPTKTSVLALAVTC-ALMILLYI 696
            |.|  :.|.||. ..:||::|:|.| ||..::.|
Worm   693 DSTELLCIAEPF-FVSSVVSLSVLCFALSAIIAI 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	10/38 (26%)
		PAN_AP_HGF	131..210	CDD:238532	30/78 (38%)
		PAN_1	236..327	CDD:394981	18/91 (20%)
		ZP	382..598	CDD:214579	67/278 (24%)
noah-2	NP_502699.1	PAN_1	28..112	CDD:278453	20/67 (30%)
		PAN_AP_HGF	125..203	CDD:238532	30/79 (38%)
		PAN_AP_HGF	217..292	CDD:238532	18/97 (19%)
		PAN_1	310..382	CDD:278453	16/83 (19%)
		ZP	392..634	CDD:214579	69/260 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I6725
eggNOG	1	0.900	-	-		E1_28JEZ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28766
OrthoDB	1	1.010	-	-		D200714at33208
OrthoFinder	1	1.000	-	-		FOG0012727
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930