DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tyn and dpy-1

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001370799.1	Gene:	dpy-1 / 175342	WormBaseID:	WBGene00001063	Length:	1427	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	78/368 - (21%)
Similarity:	130/368 - (35%)	Gaps:	46/368 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 EDPNLTNLTR--NDVNCDKTGTCYDVSVHCKDTRIAVQVRTNKPFNGRIYALGRSETCNIDVINS 418
            |.|.:...||  |....:.:|.   :.:.|......|||.....|.|.....|..:........|
Worm  1025 ESPEVLVTTRPENAETAENSGI---IDLECVGDGFKVQVNPPAGFRGVAVVKGYQDDARCKATAS 1086

  Fly   419 DAFRLDLTMAGQDCNTQSV-----TGVYSNTVV-LQHHSVVMTKADKIYKVKCTYD------MSS 471
            .:..|:|.::..:|....|     .|:.|:.|: |.|...:.|..|:.|.::|...      :.|
Worm  1087 SSLPLNLFISNNECGVTQVKSSDPNGLNSSLVLHLLHDDELNTAEDRAYLLQCFIGAQNQDAVVS 1151

  Fly   472 KNITFGMMPIRDPEMIHINSSPEAPPPRIRILDTRQREVETVRIGDRLNFRIEI--PEDT--PYG 532
            .|:......:...|.|.:::.|......||........|....:|..:..|.|.  ..||  .||
Worm  1152 TNLNVVRSELAIAETISLSTLPPTCTYSIRKEGPEGPIVSRAVVGQTVWHRWECDGTNDTNQAYG 1216

  Fly   533 IFARSCVAMAKDARTSFKIIDDDGCPTDPTIFPGFTADGNALQ--STYEAFRFTESYGVIFQCNV 595
            |...||.| :.|....|..:|..||.:|..:....|...::|.  :....|...::..:.|.|.:
Worm  1217 IQVHSCYA-SDDVERKFAFVDPRGCSSDLALLTDLTYADDSLTAWAASHVFNVHDAESLKFVCKL 1280

  Fly   596 KYCL---GPCE---PAVCEWNMDSFESLGRRRRRSIESNDTKSEDDMNISQEILVLDFGDEKREF 654
            ..|.   ..||   |..|.....:...|.:|..:.|.|.|......::.:   :.|..|
Worm  1281 SLCTRDGDGCEGVTPPACGNTNKTGLLLTKRLAKGINSVDEALTSALSTN---VKLTSG------ 1336

  Fly   655 FKADPSTDFAKDKTVTIIEPCPTKTSVLALAVTCALMILLYIS 697
             .:|...|..|..|.:.:      ..|:||....|::.:..:|
Worm  1337 -SSDGLEDLLKSATSSYL------FWVVALVAVAAIVAISILS 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052
		PAN_AP_HGF	131..210	CDD:238532
		PAN_1	236..327	CDD:394981
		ZP	382..598	CDD:214579	51/233 (22%)
dpy-1	NP_001370799.1	VWA	823..975	CDD:395045
dpy-1	NP_001370799.1	Zona_pellucida	1050..1299	CDD:421542	55/249 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910