DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tyn and Matn3

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_034900.4	Gene:	Matn3 / 17182	MGIID:	1328350	Length:	481	Species:	Mus musculus

Alignment Length:	403	Identity:	71/403 - (17%)
Similarity:	113/403 - (28%)	Gaps:	173/403 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RGPLLLCAVMVVLVT---LPEQIN-----AR---------------------MAFEKLTDFDFPG 50
            |||:.....:.::||   ..:|:|     ||                     ||.:.|.:..|..
Mouse   176 RGPMSNIPKVAIIVTDGRPQDQVNEVAARARASGIELYAVGVDRADMESLKMMASKPLEEHVFYV 240

  Fly    51 NTYYSVKNLS----------------LYECQGWCREEADCQAAAFSFVVNPLSPSQETHCQLQND 99
            .||..::.||                .::||..|..:.|                .:.||:
Mouse   241 ETYGVIEKLSARFQETFCALDQCMLGTHQCQHVCVSDGD----------------GKHHCE---- 285

  Fly   100 SSAANPSAAPQRSANMYYMIKLQLRSENVCHRPWSFERVPNKVIRGLDNALIYTSTKEACLSACL 164
                                         |.:.::. ....|....:|...:.|   ..|...|:
Mouse   286 -----------------------------CSQGYTL-NADGKTCSAIDKCALST---HGCEQICV 317

  Fly   165 NERR--FVCRSV-EYDYNNMKCVLSDSDRRSSGQFVQLVDAQGTDYFENLCLKPAQACKNNRSFG 226
            |:|.  :.|... .|..|        :|||:.....:.  |.||...:::|:..
Mouse   318 NDRNGSYHCECYGGYALN--------ADRRTCAALDKC--ASGTHGCQHICVND----------- 361

  Fly   227 NSQKMGVSEEKVAQYVGLHYYTDKELQVTSESACRLACEIESEFLCRSFLYLGQPQGSQYNC--- 288
                 |........:.|.....||:           .|.:.::  |.    || ..|.|:.|
Mouse   362 -----GAGSHHCECFEGYTLNADKK-----------TCSVRNK--CA----LG-THGCQHICVSD 403

  Fly   289 --RLYHLD---HKTLPDGPSTY--LNHERPLIDHGEPIGQYFENQCEKAAGLGAGSPPGTLDKID 346
              ..||.|   ..||.|...|.  :...|.||.        .|:.|      |.|:.....:|:.
Mouse   404 GAVAYHCDCFPGYTLNDDKKTCSDIEEARSLIS--------IEDAC------GCGATLAFQEKVS 454

  Fly   347 T----LPVSLDTI 355
            :    |...||.|
Mouse   455 SHLQKLNTKLDNI 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	11/66 (17%)
		PAN_AP_HGF	131..210	CDD:238532	16/81 (20%)
		PAN_1	236..327	CDD:394981	21/100 (21%)
		ZP	382..598	CDD:214579
Matn3	NP_034900.4	vWFA	75..298	CDD:294047	24/171 (14%)
		FXa_inhibition	305..341	CDD:291342	11/46 (24%)
		FXa_inhibition	347..383	CDD:291342	8/64 (13%)
		FXa_inhibition	389..425	CDD:291342	12/40 (30%)
		Matrilin_ccoil	438..478	CDD:287378	9/36 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000