DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tyn and AgaP_AGAP003012

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_311867.4	Gene:	AgaP_AGAP003012 / 1272942	VectorBaseID:	AGAP003012	Length:	695	Species:	Anopheles gambiae

Alignment Length:	699	Identity:	570/699 - (81%)
Similarity:	622/699 - (88%)	Gaps:	13/699 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLCAVMVVLVTLPEQINARMAFEKLTDFDFPGNTYYSVKNLSLYECQGWCREEADCQAAAFSFVV 83
            ||...:..||...:.:.||:||||||||||.|.||||||||||||||||||||.|||||||||||
Mosquito     8 LLLFTVCFLVAADQLVQARVAFEKLTDFDFQGTTYYSVKNLSLYECQGWCREEPDCQAAAFSFVV 72

  Fly    84 NPLSPSQETHCQLQNDSSAANPSAAPQRSANMYYMIKLQLRSENVCHRPWSFERVPNKVIRGLDN 148
            |||:|:|||.|||||.::|.||::.||||::||||:||||||||.|.|||:|||||||:||||||
Mosquito    73 NPLTPAQETLCQLQNVTAANNPASTPQRSSSMYYMVKLQLRSENACQRPWNFERVPNKIIRGLDN 137

  Fly   149 ALIYTSTKEACLSACLNERRFVCRSVEYDYNNMKCVLSDSDRRSSGQFVQLVDAQGTDYFENLCL 213
            ||||||||||||||||||:||:||||||||||||||||||||||.|||||||||||.||||||||
Mosquito   138 ALIYTSTKEACLSACLNEKRFICRSVEYDYNNMKCVLSDSDRRSVGQFVQLVDAQGVDYFENLCL 202

  Fly   214 KPAQACKNNRSFGNSQKMGVSEEKVAQYVGLHYYTDKELQVTSESACRLACEIESEFLCRSFLYL 278
            ||:||||.:|.| ...::|||::||:||||||||||||||||||:||:|||||||||||||||||
Mosquito   203 KPSQACKFSRQF-QLPRIGVSDDKVSQYVGLHYYTDKELQVTSETACKLACEIESEFLCRSFLYL 266

  Fly   279 GQPQGSQYNCRLYHLDHKTLPDGPSTYLNHERPLIDHGEPIGQYFENQCEKAAGLGAGSPPGTLD 343
            |||.||||||||||||||:||||||||||.||||||.|||.|.||||.|||.:....
Mosquito   267 GQPTGSQYNCRLYHLDHKSLPDGPSTYLNGERPLIDVGEPSGDYFENICEKQSNQAE-------- 323

  Fly   344 KIDTLPVSLDTIEDPNLTNLTRNDVNCDKTGTCYDVSVHCKDTRIAVQVRTNKPFNGRIYALGRS 408
              :||||..||:|||.:.||||||.||||||||||||||||||||||||||||||||||||||||
Mosquito   324 --NTLPVVFDTVEDPAVNNLTRNDANCDKTGTCYDVSVHCKDTRIAVQVRTNKPFNGRIYALGRS 386

  Fly   409 ETCNIDVINSDAFRLDLTMAGQDCNTQSVTGVYSNTVVLQHHSVVMTKADKIYKVKCTYDMSSKN 473
            |||||||||||.|||||||.||||||||.||:|||||||||||||||||||||||||||||||||
Mosquito   387 ETCNIDVINSDTFRLDLTMGGQDCNTQSATGIYSNTVVLQHHSVVMTKADKIYKVKCTYDMSSKN 451

  Fly   474 ITFGMMPIRDPEMIHINSSPEAPPPRIRILDTRQREVETVRIGDRLNFRIEIPEDTPYGIFARSC 538
            |:|||:|||||||||||||||||||||||||.|.||||||||||||.||||||||||||||||||
Mosquito   452 ISFGMLPIRDPEMIHINSSPEAPPPRIRILDARAREVETVRIGDRLTFRIEIPEDTPYGIFARSC 516

  Fly   539 VAMAKDARTSFKIIDDDGCPTDPTIFPGFTADGNALQSTYEAFRFTESYGVIFQCNVKYCLGPCE 603
            ||||||::::|:||||||||.||||||.||.|||||||.||||||||||||||||||||||||||
Mosquito   517 VAMAKDSKSTFQIIDDDGCPVDPTIFPAFTQDGNALQSIYEAFRFTESYGVIFQCNVKYCLGPCE 581

  Fly   604 PAVCEWNMDSFESLGRRRRRSIESNDT-KSEDDMNISQEILVLDFGDEK-REFFKADPSTDFAKD 666
            ||||||..||.||.||:||....|||| :.|:||||||||||||||||| |:|.:::.||||.:|
Mosquito   582 PAVCEWGRDSVESWGRKRRSVTASNDTVEEEEDMNISQEILVLDFGDEKNRDFLRSEASTDFGRD 646

  Fly   667 KTVTIIEPCPTKTSVLALAVTCALMILLYISTLFCYYMKKWMQPHKIVA 715
            |||||||||||||||||||||||||:|:|:||||||||||||||||::|
Mosquito   647 KTVTIIEPCPTKTSVLALAVTCALMVLVYLSTLFCYYMKKWMQPHKVMA 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052	44/50 (88%)
		PAN_AP_HGF	131..210	CDD:238532	72/78 (92%)
		PAN_1	236..327	CDD:394981	80/90 (89%)
		ZP	382..598	CDD:214579	197/215 (92%)
AgaP_AGAP003012	XP_311867.4	PAN_4	35..86	CDD:290993	44/50 (88%)
		PAN_AP_HGF	119..199	CDD:238532	72/79 (91%)
		PAN_1	224..315	CDD:278453	80/90 (89%)
		ZP	360..576	CDD:214579	197/215 (92%)
		Zona_pellucida	<490..583	CDD:278526	82/92 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	667	1.000	Domainoid score	I518
eggNOG	1	0.900	-	-		E1_28JEZ
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81365
Inparanoid	1	1.050	1183	1.000	Inparanoid score	I629
OMA	1	1.010	-	-		QHG28766
OrthoDB	1	1.010	-	-		D200714at33208
OrthoFinder	1	1.000	-	-		FOG0012727
OrthoInspector	1	1.000	-	-		oto109877
Panther	1	1.100	-	-	LDO	PTHR47327
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X161
TreeFam	1	0.960	-	-
	13	12.940