DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tyn and AgaP_AGAP000788

DIOPT Version :9

Sequence 1:	NP_001027032.1	Gene:	tyn / 3354987	FlyBaseID:	FBgn0284435	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_311329.5	Gene:	AgaP_AGAP000788 / 1272381	VectorBaseID:	AGAP000788	Length:	628	Species:	Anopheles gambiae

Alignment Length:	542	Identity:	116/542 - (21%)
Similarity:	193/542 - (35%)	Gaps:	187/542 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 GPSTYLNHERPLIDHGEPIGQYFENQCEKAAGLGAGS---------------------------- 337
            ||   |.|..|.|.||           ...|.||.|.
Mosquito    79 GP---LPHHGPPIPHG-----------PSRASLGLGQPFGPPPPPPPPQALPVAHAYHGPPPPPP 129

  Fly   338 PPGTLDKIDTLPVSLDTIEDP-------------NLTNLTRNDVNCDKTGTCYDVSVHCKDTRIA 389
            |||.| |.....:|.:.:..|             ::..:...||.|:|.|             :.
Mosquito   130 PPGML-KAQASELSPEKLYGPPLGGNELWSSPLQDMPKIVSLDVKCEKQG-------------MK 180

  Fly   390 VQVRTNKPFNGRIYALGRSETCNIDVIN--------SDAFRLDLTMAGQDCNTQSV--------- 437
            |.|:.:|||.|.:::.|...  |::.::        |.:|.:.:...|...||.:|
Mosquito   181 VFVQFDKPFFGIVFSKGHYS--NVNCVHLPAGLGKTSASFDIGIHECGTAGNTDNVLYNGYSGTD 243

  Fly   438 --TGVY-SNTVVLQHHSVVMTKADKIYKVKCT-YDMSSKNITFGMMPIRDPEM------------ 486
              .|.| .|.:|||:...|....|:..|::|| :|...|::||...|:...::
Mosquito   244 TNAGSYFENIIVLQYDPQVQEVWDQARKLRCTWHDQYEKSVTFRPFPVDMLDVIRADFAGDNVGC 308

  Fly   487 ---IHINSSPEAPPPRIRILDTRQREVE-TVRIGDRLNFRIEI-PEDTPYGIFARSCVAMAKDA- 545
               |.:...|.|            .||. .|:||..:...:.| .:|:.:.:..|:|  ||.|.
Mosquito   309 WMQIQVGKGPWA------------SEVSGLVKIGQTMTMVLAIKDDDSKFDMLVRNC--MAHDGK 359

  Fly   546 RTSFKIIDDDGCPTDPTIFPGFT------ADGNALQ-STYEAFRFTESYGVIFQCNVKYCLGPC- 602
            |...:::|..||.|.|.:...||      |..:.|. :.::||:|.:|..|.|||.::.|...|
Mosquito   360 RAPIQLVDQRGCVTRPKLMSRFTKIKNFGASASVLSYAHFQAFKFPDSMEVHFQCTIQICRYQCP 424

  Fly   603 ----EPAVCE-------------------------WNMDSFESLGRRRR-----RSIESNDTKSE 633
                :|.|.:                         .::|:......|:|     |...:.|.:.:
Mosquito   425 DQCTDPGVLDVHHLSGGPEHQQYGPPPPPPPPSPPQSLDAHVFTSNRKRDDRRIRRTRATDPEQK 489

  Fly   634 DDMNISQEILVLDFGDEKREFFKADPS----TDFA-----------KDKTVTIIEPCPTKTSVLA 683
            :|:.:::.|.|:..||..   |...||    ||.|           ::..:.:..|..|.|.|:.
Mosquito   490 EDVGLNRVIRVVSPGDLT---FPIGPSSANETDGAAAAATMVFSAREEGLICMTTPGFTVTIVVL 551

  Fly   684 LAVTCALMILLYISTLFCYYMK 705
            |::..|..:   .|...|..:|
Mosquito   552 LSILLASCV---TSAFLCIRLK 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tyn	NP_001027032.1	PAN_4	46..97	CDD:405052
		PAN_AP_HGF	131..210	CDD:238532
		PAN_1	236..327	CDD:394981	8/25 (32%)
		ZP	382..598	CDD:214579	63/261 (24%)
AgaP_AGAP000788	XP_311329.5	ZP	173..431	CDD:214579	68/286 (24%)
AgaP_AGAP000788	XP_311329.5	Zona_pellucida	<321..428	CDD:278526	32/108 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X161
TreeFam	0	0.000	Not matched by this tool.
	2	1.910