DRSC/TRiP Functional Genomics Resources

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Protein Alignment tyn and col6a5

DIOPT Version :9

Sequence 1:NP_001027032.1 Gene:tyn / 3354987 FlyBaseID:FBgn0284435 Length:715 Species:Drosophila melanogaster
Sequence 2:XP_012820988.2 Gene:col6a5 / 100486063 XenbaseID:XB-GENE-6451494 Length:2771 Species:Xenopus tropicalis


Alignment Length:687 Identity:128/687 - (18%)
Similarity:215/687 - (31%) Gaps:251/687 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VMVVLVTLPEQINARMAFEKLTDFDFPGNTYYSVKNLSL---YECQGWCREEAD----CQAAAFS 80
            :.:.|||..::.|....   |..:........|::|:..   |...|...|..:    .|||...
 Frog   274 IRIGLVTYNDETNPEFL---LNSYSSKTEILESIQNMKYVEGYTYTGRALEYVNTTYFTQAAGSR 335

  Fly    81 FVVNPLSPSQETHCQL-----QNDSSAANPSAAPQ---RSANMYYM---IKLQLRSENVCHRPWS 134
            |        :|:..|:     :.|||......|.:   |..::|.:   ||...:.:....:|  
 Frog   336 F--------EESVAQILIIVTEGDSSDTLTEPAKELKSRGISVYVVGTNIKYDRQLQEASSKP-- 390

  Fly   135 FERVPNKVIRGLDN-----ALIYTSTKEACLSACLNERRFVCRSVEYDYNNMKCVLSDSDRRSSG 194
                ..|....||:     .:.....|..|.|..||.:.:..|..:                   
 Frog   391 ----DEKFFYQLDDFDDSENVTEQLLKNLCFSIDLNIQVYSKRYAD------------------- 432

  Fly   195 QFVQLVD---AQGTDYFENLCLKPAQACKNNRSF----GNSQKMGVSEEKV--AQYVGL------ 244
             .|.|||   :.||.:|:.:           :.|    .|...:|:::.::  |||.||      
 Frog   433 -VVFLVDSSTSMGTIFFQKM-----------KDFIIHIINQLNVGINKHRIGLAQYSGLPQTEFL 485

  Fly   245 --HYYTDKELQVTSESACRLACEIESEFLCRSFLYLGQPQGSQYNCRLYHLDHKTLPDGPSTYLN 307
              ||.|.:|:               .:.:..:|.|.|.|..:.:......          ||:..
 Frog   486 LNHYETKEEI---------------LKHIKETFTYRGGPLKTGHALEFVR----------STFFI 525

  Fly   308 HER-PLIDHGEPIGQYF----ENQCEKA-----------------AGLGAGSPPGTLDKIDTLPV 350
            .|. ..|::|.|  |:.    .::.|.|                 .|:| .|....|:||.|.|.
 Frog   526 EEAGSRINYGNP--QFLVVITSSKSEDAVRRHAEELKSVGVTTISVGIG-NSDRKELEKIATDPF 587

  Fly   351 SLDTIEDPNLTNLTRNDVN-------------------CD------------------------- 371
            ...|....:::||.::..|                   |.                         
 Frog   588 VFQTTGLQHISNLQQDVANVIIAEDMLQFSPVSVVPAVCSSASVADIVFLIDESSSIGPINFQLT 652

  Fly   372 -----KTGTCYDVSVHCKDTRIAVQVRTNKP--------FNGRI----------YALGRSET-CN 412
                 |..:..|:|:  .:.|:.:.:.:::|        ||.:.          |..|::.| ..
 Frog   653 RVFLHKVVSALDISL--SNVRVGLVLYSDEPRLELKLNTFNEKYEILDFITKLPYRGGKAHTGAA 715

  Fly   413 IDVINSDAFRLDLTMAGQDCNTQSVTGVYSNTVVLQHHSVVMTKA---DKIYKVKCTYDMSSKNI 474
            :|.:....|            |:...|.....|  |..:||||..   |...|.......|...:
 Frog   716 LDFLRKKMF------------TKQNGGRPHQGV--QQIAVVMTNGQSMDNFTKPAAKLRRSGVEV 766

  Fly   475 -TFGMMPIRDPEMIHINSSPEAPPPRIRILDTRQREVETVRIGDRLNFRIE--IPEDTPYGIFAR 536
             ..|...|.|.|:..|.|.    |||..:.:     ||:......|.|||:  :..:.....||.
 Frog   767 FAVGFQNINDTELDIIASH----PPRKHVTN-----VESFLQLSNLEFRIQKRLCNEIVVKSFAV 822

  Fly   537 SCVAMA--------KDARTSFKIIDDDGCPTDPTIFP 565
            ..:|.|        ::|...| :||..|     :|:|
 Frog   823 PAIARAVKEGCVDTEEADIYF-LIDGSG-----SIYP 853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tynNP_001027032.1 PAN_4 46..97 CDD:405052 11/62 (18%)
PAN_AP_HGF 131..210 CDD:238532 17/86 (20%)
PAN_1 236..327 CDD:394981 20/105 (19%)
ZP 382..598 CDD:214579 46/217 (21%)
col6a5XP_012820988.2 vWFA 33..198 CDD:412136
VWA 237..410 CDD:395045 28/152 (18%)
vWFA 431..590 CDD:412136 40/217 (18%)
vWFA 632..797 CDD:412136 34/189 (18%)
vWA_collagen 839..1000 CDD:238749 7/21 (33%)
VWA 1026..1194 CDD:395045
VWA 1213..1385 CDD:395045
VWA 1404..1569 CDD:395045
Collagen 1835..1888 CDD:396114
Collagen 1868..1919 CDD:396114
Collagen 1929..1983 CDD:396114
Collagen 2013..2079 CDD:396114
Collagen 2072..2129 CDD:396114
VWA 2162..2307 CDD:395045
vWFA_subfamily_ECM 2366..2544 CDD:238727
Kunitz_BPTI 2649..2700 CDD:394972
KU 2717..2770 CDD:238057
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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