Protein Alignment Set1 and SETDB1

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_001353346.1
• Gene: SETDB1 / 9869
• HGNCID: 10761
• Length: 1292
• Species: Homo sapiens
• Alignment Length: 1467
• Identity: 265/1467 - (18%)
• Similarity: 453/1467 - (30%)
• Gaps: 505/1467 - (34%)

  Fly   466 EEIDNWDEEEHDKNSIVPTHYGCMAKLQPPV---PSNVNFATKL-----QSVTQPNSDPGTVDLD 522
            ||:.::.:||.:|...|......:|:|:..|   .|.|....:|     ::||  |.:....|..
Human    38 EELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT--NCESLVKDFY 100

  Fly   523 TRIALIFKGKTF---GNAP-----------PFLQMDSSDSET----DQGKPEVFSDVNSDSNNSE 569
            :::.|.::..:.   .:.|           ..|.:||.|:.:    ||...|..:.:...:.:.:
Human   101 SKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQ 165

  Fly   570 ------NKKRSCEKNNK-VLHQPNEASDISSDEELI------GKKDKS---KLSLIC-------- 610
                  |||.|.:..:| .|.|  .:.::|.|.:||      |||...   |.:||.
Human   166 KFMDAVNKKSSSQDLHKGTLSQ--MSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGK 228

  Fly   611 EKEVNDDNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESA 675
            :.:|..||...|.||...........|:...:.|..:..:.:.|..:.:|        ||.:|:.
Human   229 KYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYA--------GIVAETP 285

  Fly   676 SRLFSNGAYVHSEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVIGYIV--------E 732
            :        |.:: |:.:..|                   :||....|.|...|.:        |
Human   286 N--------VKNK-LRFLIFF-------------------DDGYASYVTQSELYPICRPLKKTWE 322

  Fly   733 ELKQILKRDV---------NKRMIEITAFKHFETWWDEHTSKARSKPLFEKAD------------ 776
            :::.|..||.         |:.|:.:.:.:..:|.|:....|:|    .|:.|
Human   323 DIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSR----VEEVDGSLVRILFLDDK 383

  Fly   777 --------STVNTPLNCIKDTSYN--EK-------NPDINLLINAHREVADFQSYSSIG--LRAA 822
                    ||...|:..:|.:|.:  ||       .|::..:.:....|...|..:..|  .:..
Human   384 RCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKPV 448

  Fly   823 MPKLPSFRRIRKHP-----SPIPTKRNFLERDLSDQEEMVQRSDSDKEDSNV------EISDTAR 876
            .|..|:.......|     ||.......||..|:...:.|.:..:.....:|      ..|....
Human   449 EPPQPTAPPAPPFPPAPPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALS 513

  Fly   877 SKIKGPVPIQESDSKSHTSGLNSKRKGSASS---------FFSSSSSSTSSEAEYEA-------- 924
            ..:.|..|   ..::::.|.|.|.....|.|         .|........:|..|.|
Human   514 ENVSGGKP---GINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYL 575

  Fly   925 -----IDCVEKARTSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVT 984
                 ..|:.:.|....:..||             :|..||..:            .:|::....
Human   576 PHVCSYTCLSRVRPMRNEQYRG-------------KNPLLVPLL------------YDFRRMTAR 615

  Fly   985 KRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISK----DSC--IGLDENGIEPTIL--R 1041
            :|.           |.:..|..:.:......|..::||.:    ..|  :.|:...::|.:|  |
Human   616 RRV-----------NRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDR 669

  Fly  1042 KI-PNTP------------KLNEECRRSLTPVPPP--GYNEEEIKKK-------------VDCKQ 1078
            |. |..|            .:...|...:...|||  .|::|.|..|             .|||.
Human   670 KFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKD 734

  Fly  1079 ----------------------------KPSFEYDRIYSDSEEE------KEYQERRK------- 1102
                                        ...::|.|:     ||      .|..:|.|
Human   735 GCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRL-----EECLPTGVYECNKRCKCDPNMCT 794

  Fly  1103 -RNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNN------------------------- 1141
             |..::..|:..:..:.|.|      ...::..::|.|.:
Human   795 NRLVQHGLQVRLQLFKTQNK------GWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDE 853

  Fly  1142 ---NSPRNKNDETRKTAISQTRSCFESASKVDTTLVNIISVENDINE--FGPHEEGDVLT--NGC 1199
               |....::.|..|........|...:|.||      :..:.|.|.  ..|.|..|..:  |.|
Human   854 YFANLDHIESVENFKEGYESDAPCSSDSSGVD------LKDQEDGNSGTEDPEESNDDSSDDNFC 912

  Fly  1200 --NKMYTNS--KGKTKRTQSPVYSEGGSSQASQASQVALEHCYSL-PPHSVSLGDYPSGKVNETK 1259
              ....|:|  :....|.|:....|.|.|:.:...    .|...| |||.......|.|..|
Human   913 KDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKD----SHPPDLGPPHIPVPPSIPVGGCN--- 970

  Fly  1260 NILKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVH 1324
                                |....:.|    |.|         |.|.::.|.......|..:.|
Human   971 --------------------PPSSEETP----KNK---------VASWLSCNSVSEGGFADSDSH 1002

  Fly  1325 FVPCDMYKTRDQNE-----EMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNTHWVDH 1384
                ..:||.:..|     ..:......|.|:..:|...||.
Human  1003 ----SSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEGDIKQ----------------------- 1040

  Fly  1385 CTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFNEDRSDE 1449
                       :||...||.              .|:.|..::...|.|   |......|.....
Human  1041 -----------AKKEDTDDR--------------NKMSVVTESSRNYGY---NPSPVKPEGLRRP 1077

  Fly  1450 PTALTNHHHNKLISKMQ-------------------GISREARSNQRRLLT---------AFGSM 1486
            |:..:.|...:|::..|                   |.||:..:.|.....         :.||.
Human  1078 PSKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSE 1142

  Fly  1487 GESELLKFNQLKFRKKQLK------FAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRE 1545
            |:....|.|.....|:|:.      ||..:.|...:.:....:.|:      |:. .||..:.|:
Human  1143 GDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDK------GES-APVRKNTRQ 1200

  Fly  1546 TKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKK----IVIYSKQ 1606
            . |:  |..|.|        ||||...|||.|::||||:||.:.:.:.:::...    :..::.:
Human  1201 F-YD--GEESCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK 1254

  Fly  1607 PIGINEEITYDYKF---PLEDEKIPCLCGAQGCRGTL 1640
            .|....|:|:||.:   .:|.:::.|.|||..|||.|
Human  1255 RIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRL 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	25/171 (15%)
		SET_SETD1	1490..1637	CDD:380946	40/159 (25%)
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..147		5/38 (13%)
		DUF5604	193..250	CDD:408109	16/56 (29%)
		Tudor_SETDB1_rpt1	260..341	CDD:410453	18/116 (16%)
		Tudor_SETDB1_rpt2	348..401	CDD:410548	9/56 (16%)
		MBD	598..673	CDD:128673	16/97 (16%)
		SET_SETDB1	675..>876	CDD:380915	28/211 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..1161		68/392 (17%)
		SET	<1203..1292	CDD:394802	31/99 (31%)