Protein Alignment Set1 and setd2

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_009290459.2
• Gene: setd2 / 794199
• ZFINID: ZDB-GENE-030131-2140
• Length: 2737
• Species: Danio rerio
• Alignment Length: 1866
• Identity: 364/1866 - (19%)
• Similarity: 615/1866 - (32%)
• Gaps: 626/1866 - (33%)

  Fly     7 INLVNNSSNSHDSSLANSKMPRNFKLLSDPQLVKCGT------------------RLYRYDGLMP 53
            :||..........||..:|.||....|..|...|..:                  :.|....:..
Zfish    51 VNLEEQGRQKVSFSLTQTKKPRQNVFLPPPSPEKSASEHSSTSQAGPVPVSVQAGQTYETKNVDT 115

  Fly    54 GDPSY------PTITPRDPRNPLIRIRARAVEPLMLLIPRFVIDSDYVGQPPAVEVTIVNLNDNI 112
            ..|:.      ||::        ..:|:|.|...| ...:.::.|..||....|......:::.:
Zfish   116 NTPAVGETQTAPTVS--------FSLRSRHVLGKM-HFKKQILSSTVVGDKSTVSTASAEISEPV 171

  Fly   113 DKQFLASMLDKCGTSDEINIYHHPITNKHLGIARIVFDSTKGARQFVEKYNQKSVMGKILDVFCD 177
                        ..||:|                     |..|:...|...|:|....::|
Zfish   172 ------------VPSDKI---------------------TSSAKVETENSLQQSHKNSVVD---- 199

  Fly   178 PFGATLKKSLESLTNSVAGKQLIGPKVTPQWTFQQAALEDTE--FIHGYPE----KNGEHIK--- 233
              |::.|.|.|..........|.||..:      ....|||:  .|..:.|    |.....|
Zfish   200 --GSSEKVSKEENPQEKIASCLKGPDSS------HIGKEDTDSSIISEHEESRKSKQCSDSKLAG 256

  Fly   234 ---DIYTTQTNHEIPNRSRDRNWNRDKERERDRHFKERSRHSSERSYDRDRGMRENVGTSIRRRR 295
               |..:|:|:..  .:|.||. |:.|........|..|  :|:...|:.|..|::....||..:
Zfish   257 LETDGQSTRTSSS--QKSNDRR-NKTKSESHSNEVKRSS--NSKTELDKSRTDRKDEEKGIRHSK 316

  Fly   296 T--FYRRRSSDISPEDSRDILIMTRERSRDSDSRPRDYCRSR----ERESFRDRKRSHEKGRDQP 354
            :  ..|..||..|..|.......:|.|||...||...|.||.    ||:|..||...||..|
Zfish   317 SDRDSRHMSSRSSRSDRDRRRTKSRSRSRSRGSRTSSYSRSERSRSERQSRTDRSHYHESER--- 378

  Fly   355 REKREHYYNSSKDREYR-------GRDRDRSAEIDQ----RDRG-----SLKY------------ 391
                 .::.||..||.|       ||.||.|...|.    |.||     |..|
Zfish   379 -----RFHRSSPHRERRSSRSRTDGRSRDSSDSEDDHRRTRTRGSDSSRSSTYSSSQKDSKSSTH 438

  Fly   392 -----------CSRYS------LHEYIETDVRRSSNTISSYYSASSL--------PIASHGFNSC 431
                       |||.|      .|...|:: ||||:.|.:.:..||.        .|::....:.
Zfish   439 SRSHRDSKPTDCSRSSESDKRAQHSKSESN-RRSSSEIDAVHKKSSARTKLEVNDKISNSNLTTS 502

  Fly   432 SFPSIENI-KTWSDRRAWTAFQPDFHPVQPPPPPPEEIDNWDEEEH------------------- 476
            |..|.:.| ||.||                           .:|||
Zfish   503 SRTSEKKIHKTSSD---------------------------SDEEHRRKRQSQGSDRSPRSGTSS 540

  Fly   477 -DKNSIVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFKGKTFGNAPPF 540
             .||.:|..:           ..|:...|:.||..:.|::.    .|::  |:|...|
Zfish   541 SRKNDLVDHN-----------SFNIGTGTERQSTDRLNTNA----KDSQ--LVFVTVT------- 581

  Fly   541 LQMDSSDSETDQGKPEVFSDVNSDSNNSENKKRSCEKNNKVLHQPNEASDISSDEELI----GKK 601
            .|.:||:.: ||..|....:.:...:.:.:|...||.|.|..|||:. .|:||.|:..    .||
Zfish   582 SQKESSNID-DQCTPPKSKNSSQQMHEATHKVNLCETNKKAEHQPSN-QDLSSLEKCTNVPESKK 644

  Fly   602 -----------DKSKLSLICEKEVNDDNMSLSSLSSQEDPIQTK--EGAEYKSIMSSYMYSHSNQ 653
                       ...||.:....||::..|.::.      |||::  ...:.:||......|.
Zfish   645 TTERLTESISITSGKLEVRSPTEVDEPGMKVTV------PIQSEVLTVGQTESICVGPAPSE--- 700

  Fly   654 NPFYYHASG-------------YGHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNFDSFSKPY 705
                 |..|             .|..:....|:.:|.:.|.        :....:.......|..
Zfish   701 -----HTMGSLTDSLSVKELPPEGSLILNTKSDESSLIISQ--------ISTPVTLTVQPCEKDS 752

  Fly   706 DYNKGALSDQNDGIRQK---VKQ----VIGYIVEELK---QILKRDVNKRMIEITAFKHFETWWD 760
            :.|.|:....|.||.:|   .|:    ::|.:..|.:   :::..||.|.|
Zfish   753 EQNIGSPEQPNTGISKKDASAKKSRWDIVGQVTSEYQSPAKLVNPDVKKVM-------------- 803

  Fly   761 EHTSKARSKPLFEKADSTVNTPLNC---IKDTSYNEKNPDIN----LLINAHREVADFQS-YSSI 817
                      |.:|.:.:..||.||   :.....:||:.:::    ....:|:|::.|.| :.:.
Zfish   804 ----------LAQKIEFSDTTPDNCSQKLDPEVPSEKSVEVHARDTTAAESHQEISSFTSNFGTK 858

  Fly   818 GLRAAMPK------------LPSFRRIRKHPSPIPTKRNFLERDLSDQEEMVQRSDSDKEDSNVE 870
            |....:.|            :..|:..::..:...||....:.|..:.:......||:.|:|:.:
Zfish   859 GTHDELQKTVEIPQSTSALVVSDFQPSKEKVNVDKTKPEIQDPDSLNHDGKCHSDDSESEESDSD 923

  Fly   871 ISDTARSKIKG-----PVPIQESDSKSHTSGLNSKRKGS---ASSFFSSSSSSTSSEAEYEAIDC 927
             ||..|..:|.     .||      |:.|..|.:..|..   |||.||.:..:.:    :|:|:
Zfish   924 -SDDGRVSLKRLHSVVVVP------KNSTIALETNDKAEPAPASSLFSGNQQTDT----HESIN- 976

  Fly   928 VEKARTSEEDSPRGY-GQRNLNQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNI 991
                    ::.|.|: .|..|.:.:..:...:........||:            .|:.:::.|:
Zfish   977 --------KEFPYGFNNQSTLKESSAALYKGSAQAACQSPNVK------------GVSYQSQSNM 1021

  Fly   992 YSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENGI---EPTILRKIPNTPKLNEEC 1053
            ...|                     |.||.:|..    :|:|..   .|.|..:|
Zfish  1022 VDST---------------------SHLEVMSAH----VDKNWSAQERPNISGQI---------- 1051

  Fly  1054 RRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYS--DSEEEKEYQERRKRNTEYMAQMEREFL 1116
                        |:|.::......:||..::.:.:.  ||...::......|....:....:
Zfish  1052 ------------NQEYVQNFEKTCEKPETDHHQYHGRPDSWNGRKGDFSVGRGDSLVWDFNQ--- 1101

  Fly  1117 EEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETRKTAISQTRSCFESASKVDT-------TLV 1174
            .||.....:..|.:..:|..:..:    .::.|...:.|||:|      :..|:|       .||
Zfish  1102 SEQPSSTFQQPDSSYSTPQPLFDS----VHREDPWAQPAISKT------SRTVNTHVPFQYHDLV 1156

  Fly  1175 NIISVENDINEFGPHEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEG--GSSQASQASQVALEHC 1237
            :.|..::..|:.....||.:|  |..             |:.:.|.|  |.|...||.:::....
Zfish  1157 HQIHPDSLTNDHDDDREGRIL--GIK-------------QASLLSAGLPGPSPFVQAPEISSNCS 1206

  Fly  1238 YSLPPHSVSLGDYPSGKVNETKNILKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMS 1302
            ::                        .|::||:...:.....|.|.|..|    ||:|......|
Zfish  1207 FT------------------------TESQNISEAPRDDNQKPHRGRGPP----KKRRQEFESES 1243

  Fly  1303 NVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHL 1367
            :.:::...:..|..|.:.:.:.......::.::....::.|..|
Zfish  1244 DNEAEAGLSKRECFDESSRPLKDAKESFHQIQEVQRPLLSLKEF--------------------- 1287

  Fly  1368 HKEPYAMFLNNTHWVDHCTTDRAFWPPPSKKRRKDD--ELIRHKTGCARTEGFYKLDVREKAKHK 1430
             .:|:.                  |...:|:::...  :||.        |..|   :.|:.|:|
Zfish  1288 -SDPFV------------------WRDKAKQKKMPPYFDLIE--------ENLY---LTERKKNK 1322

  Fly  1431 YHYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQG----ISREARSNQRRLLTAFGSMGESEL 1491
            .|                           :.|.:||.    :|:|.|:   |.:.|.|....:.|
Zfish  1323 SH---------------------------RDIKRMQCECAILSKEERA---RGILACGEDCLNRL 1357

  Fly  1492 LKF------------NQLKFRKKQ-------LKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIR 1537
            |..            :..:|:.||       |..:|.    |||.|.:.:..:..|:||.|:
Zfish  1358 LMIECSSRCLNGAYCSNRRFQMKQHADYEVILTESKG----WGLRAAKDLQPNTFVLEYCGE--- 1415

  Fly  1538 PVVADLRETKYEAIGIGSS-----YLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESE 1597
              |.|.||.|........:     |...:....|||||..||.:||:||||.|||..:..|:..:
Zfish  1416 --VLDHREFKARVKEYARNKNIHYYFMALKNNEIIDATLKGNCSRFMNHSCEPNCETQKWTVNGQ 1478

  Fly  1598 KKIVIYSKQPIGINEEITYDYKFP---LEDEKIPCLCGAQGCRGTL 1640
            .:|..::.:.:....|:|:||:|.   .|.:|  |.|||..|||.:
Zfish  1479 LRIGFFTTKAVTAGTELTFDYQFQRYGKEAQK--CFCGAPSCRGLI 1522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745	14/91 (15%)
		U2AF_lg	255..>386	CDD:273727	43/147 (29%)
		N-SET	1352..1496	CDD:463344	22/161 (14%)
		SET_SETD1	1490..1637	CDD:380946	50/173 (29%)
setd2	XP_009290459.2	None