DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Set1 and setd1b

DIOPT Version :10

Sequence 1:NP_001015221.1 Gene:Set1 / 3354971 FlyBaseID:FBgn0040022 Length:1641 Species:Drosophila melanogaster
Sequence 2:NP_001072649.1 Gene:setd1b / 780106 XenbaseID:XB-GENE-5842344 Length:1956 Species:Xenopus tropicalis


Alignment Length:2114 Identity:547/2114 - (25%)
Similarity:828/2114 - (39%) Gaps:666/2114 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 VNNSSNSHDSSLANSKMP---RNFKLLSDPQLVKCGTRLYRYDGL---MPGDPSYPTITPRDPRN 68
            :|.....:..|.:..|..   |::||:.||.|.|...:|||||||   ||.....|..:.|||| 
 Frog    27 INGMEAGNQPSTSGEKKSHHWRSYKLIIDPALRKGQHKLYRYDGLSFSMPNSGVPPVDSVRDPR- 90

  Fly    69 PLIRIRARAVEPLMLLIPRFVIDSDYVGQPPAVEVTIVNLNDNIDKQFLASMLDKCGTSDEINIY 133
             :.||..:..| |.|.:|:..||..|||..|..:||...|||||.:.||..|..|.|..:|:.|.
 Frog    91 -IGRIWTKTKE-LDLPVPKLKIDEFYVGPVPPKQVTFAKLNDNIRENFLGDMCKKYGEVEEVEIL 153

  Fly   134 HHPITNKHLGIARIVFDSTKGARQFVEKYNQKSVMGKILDVFCDPFGATLKKSLESLTNSV---- 194
            ::|...||||||:::|.|.||||..|:..:..||||.|:.|..|..|.|..:..:.|.|..    
 Frog   154 YNPKNKKHLGIAKVIFASVKGARDAVKHLHNTSVMGNIIHVELDTKGETRMRFYDLLVNGFYTPQ 218

  Fly   195 ---AGKQL-----------------------IGPKVTPQWTFQQAALEDTEFIH---------GY 224
               .|..|                       |||.|||.        ..|.|.|         |.
 Frog   219 TLPVGSDLDASPTVNETPQVVESVKRTKETAIGPSVTPN--------SSTPFSHDTAYSSSRQGT 275

  Fly   225 PEKNGEHIKDIYTTQTNHEIPNRSRDRNWNRDKERERDRHFKERSRHSSERS-----YDRDRGMR 284
            |....:     :|.| :...|:..|           ....|.:.|.:||.::     |.:|.|.:
 Frog   276 PNSYSQ-----FTPQ-SQGTPHTPR-----------LGTPFSQDSSYSSRQTTPAFHYGQDSGFK 323

  Fly   285 ----ENVGTSIRRRRTFYRRRSSDISPEDSRDILIMTRERSRDSDSRPRDYCRSRERESFRDRKR 345
                ||..|....||..:....|..|...:.....:||.:. :....||....|....:::....
 Frog   324 PRRHENKFTDAYNRRPGHHYVHSSGSYRGTEHTFNVTRPQP-EPVQVPRTPPLSHSSGNYKSAFS 387

  Fly   346 SHEKGRDQPREKREHYYNSSKDREYRGRDRDRSAEIDQRDRGSLKYCSRYSLHEYIETDVRRSSN 410
            .::.....|:.....|..:|:|.|||                                  |....
 Frog   388 PYQGNTVFPQTDESQYPQTSRDMEYR----------------------------------RTGPQ 418

  Fly   411 TISSYYSASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHPVQPPPPPPEEIDNWDEEE 475
            |..||..|        |.||.|. .::.:|.              .|.:||||.|      |...
 Frog   419 TSDSYSDA--------GCNSASL-ELKPVKE--------------KPEEPPPPEP------DSTT 454

  Fly   476 HDKNSIVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFK---------- 530
            ..|.|...|...|..   |..|:       |::..|.||      ||||||::.|          
 Frog   455 EQKASFSQTPERCET---PGTPT-------LEAELQHNS------LDTRIAMLLKEQRTQLHLIA 503

  Fly   531 ------------GKTFGNA-------PPF--------LQMDSSDSET--DQGKPEVFSDVNSDSN 566
                        |....::       ||:        :...|..|.|  :...|....|.:.|..
 Frog   504 GDQNSDNEIRMEGSPISSSSSQLSPIPPYSSGSRYQDVTPSSRPSSTGLEDISPTPLPDSDDDDE 568

  Fly   567 NSENKKRSCEKNNKV-----LHQPNEASDISSDEELIG--------KKDKSKLSLICEKEVNDDN 618
            ........|:.:...     ::|....::....:||:.        |.|:...|...:.|::||.
 Frog   569 PIPGTASLCQNSRSASPIDQINQSGRKTESLDKKELVAGDETPTSEKMDEGHPSSGEDMEISDDE 633

  Fly   619 MSLSSLSSQEDPIQTKEGAEYKSIMSS-------------------------------------- 645
            ::.|.::|.|..|.:      .|::||                                      
 Frog   634 VTPSPITSAECAITS------SSVISSVIPIPPPGFPPLPPPPPPQPGFPMPPPLPPPPPPTHPS 692

  Fly   646 -----------------YMYSHSNQNPFYYH--------ASGYGHYLSG------IPSESASRLF 679
                             ::..|.   |.|:|        .:..|::..|      :.::..||:.
 Frog   693 VTVPPPPLPAPPGVPPHHILHHP---PPYHHFPVMQGEMMNVLGNHWGGMTMSFQMQTQMLSRMM 754

  Fly   680 -SNGAYVHSEYLKAVASF-------------------------NFDSFSKP--YDYNKGALSDQN 716
             ..|:|.:..::.....|                         .||....|  |::.|      .
 Frog   755 QGQGSYPYHHFMGGSMQFGNQHPYRPFAISAHLTRGQPWPPFPKFDPSVPPPGYEHKK------E 813

  Fly   717 DGIRQKVKQVIGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPLFEKADSTVNT 781
            |..:..|..|:..||:|||.|:|||:|::|:|:.||:.|:.|||      :.:.|.:::.:.|.:
 Frog   814 DPHKATVDGVLQVIVKELKAIMKRDLNRKMVEVVAFRAFDEWWD------KKERLAKQSLTPVKS 872

  Fly   782 PLNCIKDTSYNEKNPDINLLINAHR-EVADFQSYS-SIGLRAAMPKLPSFRRIRKHPSPI----- 839
            ..:..:|....:::...:||.:.:: |...|:... .||||.|: :||||:..||.|...     
 Frog   873 GESKEEDKQKTKEHITSSLLESWNKGEGLGFEGIGLGIGLRGAI-RLPSFKVKRKEPPDAALAGD 936

  Fly   840 -----PT-------KRNFLERDLSD---------------------------QEEMVQRSD---- 861
                 |:       :.:..:||:|.                           :||:....|    
 Frog   937 QKRIRPSHSVDDEDEESERDRDISSTASDLSKKDADAVNNRRRPARPLDSEGEEEVESEGDDGET 1001

  Fly   862 SDKEDSNVEISD---------TARSKIKGPVPIQESDSKSHTSG----LNSKRKGS---ASSFFS 910
            ||||||:.|..|         :::.::.|.....:.|..:.:||    |.|:.:.:   |||...
 Frog  1002 SDKEDSSSEKEDQDDGSVSALSSKKQLYGDKEGDDEDDDTQSSGKEEDLVSEEEDTTSVASSRAE 1066

  Fly   911 SSSSSTSSE-AEYE-AIDCVEKARTSEEDSPRGYG-----QRNLNQRTTTIRNRNLVGTMDVINV 968
            ..||..|.| :||| :.|..||....:|:....:|     .::|.|......:|.    .|... 
 Frog  1067 MDSSDESEESSEYESSSDSDEKEEEDDEEEELVFGDDQSEDQDLGQEYEVETDRE----EDFFR- 1126

  Fly   969 RNL--CSG---SNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCI 1028
            .||  ||.   :.:.:.|:..::.::::...|.::   ||.  |::||:...|.:.:|..:|:..
 Frog  1127 ENLSECSSLPKAGDVELEDEMQKVEEDVARQTTQE---TLH--LRKKNLDVPLVESKECKQDTLD 1186

  Fly  1029 GLDENGIEP---TILRKIPNTPK-LNEE---CRRSLTPVP--------------------PPG-Y 1065
            .:::....|   .:.::....|. :|||   ....|.|||                    |.| :
 Frog  1187 KVEKLFAVPMQEEVFKEHEKAPSPMNEEEEYIELQLEPVPLVPEGAAPAAQEPVIIRPLTPTGAF 1251

  Fly  1066 NE-------EEIKKKVDCKQKPSFEYDRIY---------SDSEEEKEYQERRKRNTEYMAQMERE 1114
            .|       ||.|.:|:..|..: |.:.:|         :.|:.|..:|...|     :|.....
 Frog  1252 GETGPVLKLEEPKLQVNLTQFAT-EDEELYPRTPGRDTAAHSDTEVTFQPGLK-----VAPSSLP 1310

  Fly  1115 FLEEQEKRIEKSL----------------DKNL-QSPNN--IVKNNNSPRNKNDETRKTA----- 1155
            ||....|..|..|                :::| ::|..  :||:::..::::.||....     
 Frog  1311 FLPSHNKEEECLLPPEKHAGHLTVTKMLSEEDLPRTPGRDIVVKSSHLGKSQSTETVPATPGSDA 1375

  Fly  1156 ---------------------ISQTRS----------------------------CFESASK--V 1169
                                 :||:..                            |..|..|  |
 Frog  1376 PLTGSSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPGRDFNFTPTFPESNSIFPCHPSGKKPSV 1440

  Fly  1170 D-----------TTLVNIISVENDINEFG------PHEE----GDVLTNGCNKMYTNSKGKTKRT 1213
            |           :..:.:.||.:.| .|.      ||.:    .|.|.:.....|.:.|      
 Frog  1441 DEPDEKSFKEPTSASLTMNSVPSPI-PFASPPRGLPHMDIRLGADDLESSDTPAYLSDK------ 1498

  Fly  1214 QSPVYSEGGSSQASQASQVALEHCYSLPP-------------HSVSLGDYPSGKVNETKNILKRE 1265
               :.||....:.::....:.:.....||             ..:|..::.:.|..||.:.:...
 Frog  1499 ---LLSEESECEFTKVHLTSTDESAPSPPLPPAEKRKGDRSKKPLSAHEFETEKNYETSSAVAMS 1560

  Fly  1266 AENIAIVSQMTRTGPGRPR-----KDPICIQ---------------------------------- 1291
            ..  |:..||.   .|:|.     |||..:.                                  
 Frog  1561 EG--ALGKQMF---IGQPDAVSGIKDPAAVPLDFRNDSLSENTVHEPIIQKVPLKELENQWNEVL 1620

  Fly  1292 KKKRDLAPRMSNVKSKMTPNGDEW-----PDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGI 1351
            |::.|:.....:..|:.....||:     |:.:      .|..|:|.|.:.|||.|||.....||
 Frog  1621 KEEEDITKHKKSRNSRHNNRYDEFSTVPSPEFS------PPRAMFKPRSEFEEMTILYDIWNGGI 1679

  Fly  1352 DAEDINFIKMSYLDHLHKEPYAM-FLNNTHWVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCART 1415
            |.|||.::.::| |.|.::...| :||:|.||.|.:|  :.:.|  ||:::||.|..|.|||||:
 Frog  1680 DDEDIKYMCITY-DRLLQQDNGMDWLNDTLWVYHPST--SVYSP--KKKKRDDGLREHVTGCARS 1739

  Fly  1416 EGFYKLDVREKAKHKYHYAKANTE---DSFNEDRSDEPTALTNHHHNKLISKMQGISREARSNQR 1477
            ||:||:|.::|.|:..:......|   |:..:....:|.|.|.            ...|.||.||
 Frog  1740 EGYYKIDKKDKLKYLINNRSLTEELPIDTQGKSIPAQPQASTR------------AGSERRSEQR 1792

  Fly  1478 RLLTAFGSMGESELLKFNQLKFRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVAD 1542
            |||::|....:|:||||||||||||:|:|.||.||||||||||||.|||||||||||.||.|:||
 Frog  1793 RLLSSFTGSCDSDLLKFNQLKFRKKKLRFCKSHIHDWGLFAMEPIIADEMVIEYVGQNIRQVIAD 1857

  Fly  1543 LRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQP 1607
            :||.:||..||||||:||:|.:||||||||||.||||||||||||||||||:||:|||||||||.
 Frog  1858 MREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQY 1922

  Fly  1608 IGINEEITYDYKFPLEDEKIPCLCGAQGCRGTLN 1641
            |.:|||||||||||:||.||||||||:.||||||
 Frog  1923 INVNEEITYDYKFPIEDVKIPCLCGAENCRGTLN 1956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set1NP_001015221.1 RRM_Set1 99..191 CDD:409745 38/91 (42%)
U2AF_lg 255..>386 CDD:273727 26/139 (19%)
N-SET 1352..1496 CDD:463344 53/147 (36%)
SET_SETD1 1490..1637 CDD:380946 118/146 (81%)
setd1bNP_001072649.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46 3/18 (17%)
RRM_Set1B 119..211 CDD:409965 38/91 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..478 66/350 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..637 19/134 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..696 0/33 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 926..1148 47/226 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1341..1386 6/44 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1464 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1512..1553 4/40 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1627..1655 4/33 (12%)
N-SET 1669..1811 CDD:463344 58/158 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1766..1790 6/35 (17%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1788..1793 3/4 (75%)
SET_SETD1 1805..1952 CDD:380946 118/146 (81%)

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