Protein Alignment Set1 and Kmt2b

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_001277502.1
• Gene: Kmt2b / 75410
• MGIID: 109565
• Length: 2722
• Species: Mus musculus
• Alignment Length: 238
• Identity: 93/238 - (39%)
• Similarity: 125/238 - (52%)
• Gaps: 35/238 - (14%)

  Fly  1428 KHKYH---------------------YAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQGISRE 1471
            |.:||                     |.:..|.|.||        .|.:.|  :::.:......|
Mouse  2496 KFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFN--------FLASQH--RVLPEGATCDEE 2550

  Fly  1472 ARSNQRRLLTAFGSMGESELLKFNQLKFRKKQ-LKFAKSAIHDWGLFAMEPIAADEMVIEYVGQM 1535
            ....|.|......|:.....::|..||...|: :...:||||..|||....|.|.||||||.|.:
Mouse  2551 EDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIV 2615

  Fly  1536 IRPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKI 1600
            ||.|:.|.||..|:..||| .|:||:|...::|||..||.||||||||.|||:::||.:|.:|.|
Mouse  2616 IRSVLTDKREKFYDGKGIG-CYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHI 2679

  Fly  1601 VIYSKQPIGINEEITYDYKFPLED--EKIPCLCGAQGCRGTLN 1641
            ||::.:.|...||:|||||||:||  .|:||.|||:.||..||
Mouse  2680 VIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	15/88 (17%)
		SET_SETD1	1490..1637	CDD:380946	75/149 (50%)
Kmt2b	NP_001277502.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q9UMN6	17..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..524
		PHA03378	<483..>702	CDD:223065
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..783
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..872
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	899..964
		zf-CXXC	963..1010	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1032..1076
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1088..1138
		PHD1_KMT2B	1209..1255	CDD:277064
		PHD2_KMT2B	1257..1306	CDD:277066
		PHD3_KMT2B	1343..1399	CDD:277068
		Bromo_ALL-1	1380..1522	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1550..1572
		ePHD_KMT2B	1587..1691	CDD:277164
		FYRN	1739..1786	CDD:461787
		PHA03307	1814..>2193	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2065..2113
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2125..2169
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2288..2365
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2391..2417
		FYRC	2420..2504	CDD:197781	3/7 (43%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q9UMN6	2515..2520		0/4 (0%)
		SET_KMT2A_2B	2569..2722	CDD:380947	77/153 (50%)