DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set1 and NSD1

DIOPT Version :10

Sequence 1:NP_001015221.1 Gene:Set1 / 3354971 FlyBaseID:FBgn0040022 Length:1641 Species:Drosophila melanogaster
Sequence 2:NP_071900.2 Gene:NSD1 / 64324 HGNCID:14234 Length:2696 Species:Homo sapiens


Alignment Length:2226 Identity:430/2226 - (19%)
Similarity:701/2226 - (31%) Gaps:805/2226 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQDVR---NINLVNNSSNSHDSSLANSKMPRNFKLLSDPQLVKCGTRLYR---YDGLMPGDPSYP 59
            :||:.   |:..:|.|::..:|             ..||:  |..:|...   ...|.||.|:..
Human    75 LQDLASMINVEYLNGSADGSES-------------FQDPE--KSDSRAQTPIVCTSLSPGGPTAL 124

  Fly    60 TI--TPRDPRNPLIRIR-ARAVEPLMLLIPRFV------IDSDYVGQPPAVEVTIVNLNDNIDKQ 115
            .:  .|....:|.:::: .:.::...|....|.      :||:...:.|..|      :::|::.
Human   125 AMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTE------DESIEEI 183

  Fly   116 FLASMLD-KCG--TSDEINI--------------YHHPITNKHLGIARIVFDSTKGARQFVEKYN 163
            |..:..: .|.  |..|..:              .|..:.:..|.:|..........|..|:..|
Human   184 FEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSN 248

  Fly   164 QKSVMGKILDVFCDPF-----GATLKKSLESL----------TNSVAGKQLIGPKVTPQWTFQQA 213
            :|:.:      ...||     ..|:::.|.|:          :.|..|..|..|..:...|.|  
Human   249 EKAAL------LPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQ-- 305

  Fly   214 ALEDTEFIHGYPEKNGEHIK------------------------DIYTTQTNHEIPNR------- 247
                 |.....|:|....:|                        .:..|.:..::.||       
Human   306 -----ELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYY 365

  Fly   248 ------SRDRNW----------------------NRDKERERDRHFKERSRHSSE--------RS 276
                  ..:|.|                      .|.|::|:....|...:..|:        ..
Human   366 VEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQ 430

  Fly   277 YDRDRGM--RENVGTSIR---RRRTFYRRRSSDISPEDSRDILI------MTRERSRDSDSRPRD 330
            ||..:|.  |:.:..||:   .....:...::|  ||...|:|:      :..:....:|.:.:.
Human   431 YDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTND--PESEHDLLLNGCLKSLAFDSEHSADEKEKP 493

  Fly   331 YCRSRERESFRDRKR-SHEKGRDQPREKREHYYNSSKDREYRGR---------------DRDRSA 379
            ..:||.|:|..:.|| |.:||..|        :.:.|| |.||:               |...|.
Human   494 CAKSRARKSSDNPKRTSVKKGHIQ--------FEAHKD-ERRGKIPENLGLNFISGDISDTQASN 549

  Fly   380 EIDQ---------RDRGSLKY--CSRYSLHEYIETD-----------------------VRRS-- 408
            |:.:         ...||..:  |.:.:..:..||.                       .:||  
Human   550 ELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLV 614

  Fly   409 --SNTISSYYSASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHPVQPPPPPPEEI--- 468
              |.....|..|......|...:.|         |.||..:     .|..|::........:   
Human   615 CGSKVKLCYIGAGDEEKRSDSISIC---------TTSDDGS-----SDLDPIEHSSESDNSVLEI 665

  Fly   469 -DNWDEEEH----DKNS------IVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSDPGTVDLD 522
             |.:|..|:    .||.      ...|:....|| |.|:.|| :....|...|: :::|||....
Human   666 PDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAK-QKPLISN-SHTDHLMGCTK-SAEPGTETSQ 727

  Fly   523 TRIA------LIFKGKT-FGN---APPFLQMDSSDSETDQGKPEVFSDVNSDSNNSENKKRS--C 575
            ..::      |:.|.:: |.|   :|.|....|..||....|....:.....|.:.:.|.||  |
Human   728 VNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKC 792

  Fly   576 E-KNNKVLHQP---NEASDI---SSDEELIGKKDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQT 633
            : |.|.|:.:|   ||...:   |||.:      .|.|:.| .|....|.:.|  |::..:  :|
Human   793 KHKENPVMAEPPVINEECSLKCCSSDTK------GSPLASI-SKSGKVDGLKL--LNNMHE--KT 846

  Fly   634 KEGAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNF 698
            ::.::.::.:..::.|...:  ..|.:.|.....||....|...|||           :.:|.|.
Human   847 RDSSDIETAVVKHVLSELKE--LSYRSLGEDVSDSGTSKPSKPLLFS-----------SASSQNH 898

  Fly   699 DSFSKPYDYNKGALSDQNDGIRQKVKQVIGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHT 763
            ......|.::                        .|..:||                    |.|.
Human   899 IPIEPDYKFS------------------------TLLMMLK--------------------DMHD 919

  Fly   764 SKARSKPLFE-----------KADSTVNTPLNCIK------DTSYNEKNPDINLLINAHREVADF 811
            ||.:.:.|..           :.|.:.|:|:...|      .|..:||..| ....:|:...:..
Human   920 SKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGD-GTQNSANPSPSGG 983

  Fly   812 QSYSSIGLRAAMPKLPSFRR----IRKHPSPIPTKRNFLERDLSDQ------EEMVQRSDSDKE- 865
            .|..|..|.|::|.|.|.:|    ..|..|...|:||......|.:      .:||:.:.:.|. 
Human   984 DSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKAL 1048

  Fly   866 --------------------DSNVEISDTARSKIKGPV---PIQ-----ESDSKSHTSGL--NSK 900
                                ..:.|...:.|...:.|.   |:|     .|:...|.|.:  :||
Human  1049 KTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSK 1113

  Fly   901 RKGSASSFFSSSSSSTSSEAEYEAIDCVEKARTSEEDSPRGYGQ-------RNLNQRTTTIRNRN 958
            .|.|.....|....|..:....|    ::....||.|...|..|       :.||||.|..|.| 
Human  1114 VKQSDPGKISEKGLSFENGKGPE----LDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKR- 1173

  Fly   959 LVGTMDVINVRNLCSGSNEFK-KENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEI 1022
                            .|.|| |||.....:..:.||..::. |..||..:..:.|.:...|.|.
Human  1174 ----------------MNRFKEKENSECAFRVLLPSDPVQEG-RDEFPEHRTPSASILEEPLTEQ 1221

  Fly  1023 SKDSCIGLDENGIEPTI----------LRKIPNTPKLNEECRRSLTP---VPPPGYNEEEIKKKV 1074
            :...|  ||..|....:          :.|.|..|        ||||   :|.|....|  ||::
Human  1222 NHADC--LDSAGPRLNVCDKSSASIGDMEKEPGIP--------SLTPQAELPEPAVRSE--KKRL 1274

  Fly  1075 DCKQKPS-------FEYDRIYSDSEEEKEYQER---------------RKRNTEYMAQ------- 1110
               :|||       .|||:|::..:::|:.||:               |.|::....|       
Human  1275 ---RKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLI 1336

  Fly  1111 --------MERE--FLE------------------------------------------------ 1117
                    :|||  |||                                                
Human  1337 STKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYE 1401

  Fly  1118 --EQEKRIEKSLDKNLQSPNNIVKNNNSPRNKN-DETRKTAISQTRSCFESASK---VDTTLV-- 1174
              .|.|..:|.|:.|...|..:.|..:...:|. .|........|.||..|.||   ..||.:  
Human  1402 SKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFD 1466

  Fly  1175 ---------------NIISVENDIN---------EFGPH----------EEGDVLTNGCNKMYTN 1205
                           ....|:||.:         |..||          |||.....|   |..:
Human  1467 KPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPG---MPAS 1528

  Fly  1206 SKGKTKRTQSPVYSEGGSSQASQASQVAL---EHCYSLPPHSVSLGDYPSGK--VNETKN----- 1260
            .|.:.:|.......|.......:..::.|   :.|.:.....:.|.:.|.||  .||.:.     
Human  1529 KKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTC 1593

  Fly  1261 -ILKREAENI---------------------------------------------AIVSQMTRTG 1279
             :.|:..|::                                             |.||    ..
Human  1594 FVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVS----AS 1654

  Fly  1280 PGRPRK----------DPICIQKKKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVHFVP---CDMY 1331
            .||..:          :..|:....:.||   ||  |.:.||            ||.|   |   
Human  1655 KGRLMRCVRCPVAYHANDFCLAAGSKILA---SN--SIICPN------------HFTPRRGC--- 1699

  Fly  1332 KTRDQNEEMV-ILYTFL-TKG-----IDAEDINFIKMSYLDHLHKEPYAMFLNNTHWVDHCTTDR 1389
                :|.|.| :.:.|: ::|     .|:....|         |:|...:.:...:|  :|...:
Human  1700 ----RNHEHVNVSWCFVCSEGGSLLCCDSCPAAF---------HRECLNIDIPEGNW--YCNDCK 1749

  Fly  1390 A------------------FWPP--------PSK--KRRKD------------DELIRHKTGCAR 1414
            |                  :||.        ||.  |.|.|            |.|..|:   ||
Human  1750 AGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQ---AR 1811

  Fly  1415 ------------------TEGFYKLDVREKAKHKYHYAKANTE-DSFNEDRSDE--PTALTNHHH 1458
                              .:|.||..::|.|. ::...||..| ....|||.::  |....:...
Human  1812 VFPYMEGDVSSKDKMGKGVDGTYKKALQEAAA-RFEELKAQKELRQLQEDRKNDKKPPPYKHIKV 1875

  Fly  1459 NKLISKMQ----GISREARSN----------------QRRLL-----TAFGSMGESELLKFNQLK 1498
            |:.|.::|    .:|...|.|                .|.||     |...:.|..:    ||. 
Human  1876 NRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQ----NQC- 1935

  Fly  1499 FRKKQ---LKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFR 1560
            |.|:|   ::..::....|||.....|...|.|.||||::|.......|....:...|.:.|:..
Human  1936 FSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLT 2000

  Fly  1561 IDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFP-LED 1624
            :|.:.||||...||.|||:||.|.|||..:..::..:.::.:::...|....|:|::|... |.:
Human  2001 LDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGN 2065

  Fly  1625 EKIPCLCGAQGCRGTL 1640
            .|..|.|||..|.|.|
Human  2066 GKTVCKCGAPNCSGFL 2081

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set1NP_001015221.1 RRM_Set1 99..191 CDD:409745 19/123 (15%)
U2AF_lg 255..>386 CDD:273727 35/174 (20%)
N-SET 1352..1496 CDD:463344 42/229 (18%)
SET_SETD1 1490..1637 CDD:380946 45/150 (30%)
NSD1NP_071900.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..252 7/44 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..311 7/36 (19%)
PWWP_NSD1_rpt1 318..433 CDD:438989 12/114 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..514 8/26 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..891 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 936..1035 23/99 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1134 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1272 10/38 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1294..1344 6/49 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1428 7/45 (16%)
TNG2 <1431..1587 CDD:227367 32/158 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1534 12/56 (21%)
PHD1_NSD1_2 1545..1587 CDD:277118 8/41 (20%)
PHD2_NSD1 1592..1638 CDD:277120 2/45 (4%)
PHD3_NSD1 1639..1692 CDD:277123 13/73 (18%)
PHD4_NSD1 1709..1748 CDD:277126 8/49 (16%)
PWWP_NSD1_rpt2 1755..1850 CDD:438992 17/98 (17%)
AWS 1901..1939 CDD:465559 8/42 (19%)
SET_NSD1 1941..2082 CDD:380987 43/141 (30%)
Inhibits enzyme activity in the absence of bound histone 2060..2066 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2091..2111
PHD5_NSD1 2120..2162 CDD:277129
C5HCH 2161..2210 CDD:465605
PHA03247 <2208..2574 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2422
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2464..2499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2553..2575
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2595..2616
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2665..2696
Blue background indicates that the domain is not in the aligned region.

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