|
Fly 250 DRNWNRDKERERDRHFKERSRHSSER-------SYDRDRGMREN--------VGTSIRRRRT--- 296
|.|...:..:||:| |||.|...|| ..||.|.:::. ||:.|...||
Human 3387 DNNPFSESFQERER--KERLREQQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVS 3449
Fly 297 ---FYRRRSSDISPEDSRDILIMTRERSRDSDSRPRDYCRSRERESFRDRKRSHEKGRDQP---- 354
|| |||: |.|:. ||
Human 3450 QIPFY---SSDL----------------------PCDFM--------------------QPLGPL 3469
Fly 355 REKREHYYNSSKDREYRGRDRDRSAEIDQR---DRGSLKYCSRYSLHEYIETDVRRSSNTISSYY 416
::..:| :.:..::.|: .:||: :..|...:::|:.||.....|...
Human 3470 QQSPQH--------------QQQMGQVLQQQNIQQGSI---NSPSTQTFMQTNERRQVGPPSFVP 3517
Fly 417 SASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQ-----PDFHPVQPPPPP------PEEIDN 470
.:.|:|:.| |:..::|......:.|:|| |.|.|..|..|| |...|:
Human 3518 DSPSIPVGS--------PNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDS 3574
Fly 471 WDEEEHD-----------KNSIVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSD------PGT 518
.....|. .:.|:|...|...:.:.....:...:||..|. |:|| ||.
Human 3575 TITHGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPST--PHSDITAPPTPGI 3637
Fly 519 VDLDTRIALIFKGKTFGNAPPFLQMDSSDSE-TDQGKPEVFSDVNSDSNNSENKKRSCEKNNKVL 582
.:..:..|: |:.|| ..|...|....|...:.|....:...|..||:
Human 3638 SETTSTPAV-----------------STPSELPQQADQESVEPVGPSTPNMAAGQLCTELENKL- 3684
Fly 583 HQPN-EASDISSDEELIGKKDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQTK----EGAEYKSI 642
|| :.|..:.:::.....:..|||: |.|.:|: |.||.:|
Human 3685 --PNSDFSQATPNQQTYANSEVDKLSM-------------------ETPAKTEEIKLEKAETES- 3727
Fly 643 MSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRL-FSNGAYVHSEYLKAVASFNFDSFSKPYD 706
.|.:...:| ..||:.|.. .|||.....:.|.|
Human 3728 ---------------------------CPGQEEPKLEEQNGSKVEG---NAVACPVSSAQSPP-- 3760
Fly 707 YNKGALSDQNDGIRQKVKQVIGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPL 771
::.||.:.:.|... |.||.:|| :|..|..|
Human 3761 HSAGAPAAKGDSGN-----------ELLKHLLK------------------------NKKSSSLL 3790
Fly 772 FEKADSTVNTPLNCIKDTSYNEK-NPDINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKH 835
.:|.:.::.:..:|.||....|| ||...| :....|.....|....:||.......:|.
Human 3791 NQKPEGSICSEDDCTKDNKLVEKQNPAEGL------QTLGAQMQGGFGCGNQLPKTDGGSETKKQ 3849
Fly 836 PS-----------PIPTKRNFLERDLSDQEEMVQRSDSD---KEDSNV----------------- 869
.| |...|| ::|..:::.|...:|:. |:.:|:
Human 3850 RSKRTQRTGEKAAPRSKKR---KKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTPPASLPPTPPPM 3911
Fly 870 -------------EISDTAR-------SKIKGPVPIQ-----ESDSKSHTSGLNSKR-------- 901
|::..|. :|..||.|.| :.|..:.......|.
Human 3912 ACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLP 3976
Fly 902 ------------------KGSASSFFSSSSSSTSSEAE---YEAIDCVEKARTSEEDSPRGYGQR 945
:.:..||..|||..:....| |..:..|::.......||
Human 3977 TPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSP------ 4035
Fly 946 NLNQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDT----DEDNDR----- 1001
:|.:....:|.:...:.|..|.....:|..: ..:..|
Human 4036 -------------------IIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLIS 4081
Fly 1002 ---TLFPALKEKNISTIL---SDL--------EEISKD---SCIGL-DENGIEP-------TILR 1041
||.|...| |||::: ||| .|:|.. ..:|| ..:.|.| .:||
Human 4082 VAITLHPTAAE-NISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLR 4145
Fly 1042 KIP----NTPKLNEECRRSLTPVP-PP------GYNEEE--------IKKKVDCKQKPSFEYDRI 1087
..| |.|:|....|.....|| || ||.:.. ::.:..|..|. :
Human 4146 GPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKV------V 4204
Fly 1088 YSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETR 1152
...|...|.:::....|.: ..|..||:|| |....|.|..:..:::.:.||.|.:
Human 4205 ILGSGVRKSFKDLTLLNKD---------SRESTKRVEK--DIVFCSNNCFILYSSTAQAKNSENK 4258
Fly 1153 KTAISQTRS--------------------------------------------CFESAS------ 1167
::..|..:| .||:|.
Human 4259 ESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPD 4323
Fly 1168 --KVDTTL------------------------------VNII--------SVENDINEF------ 1186
||...| ::|: ..|::|:||
Human 4324 ELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGT 4388
Fly 1187 ----GP-----------HEEGDVLTNG----------------C----NKMYTNSKG-------- 1208
.| |||||.||:| | .::|....|
Human 4389 SLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELA 4453
Fly 1209 -------------------------------------------KTKRTQSPVYSEGGSS------ 1224
|.|....|::...|..
Human 4454 LRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSY 4518
Fly 1225 ---------QASQASQVA-------LEHCY---SLPPHSVS------------------LGDYPS 1252
|..:..|:| .:|.: ||..|::. :| |.:
Human 4519 FAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVG-YEA 4582
Fly 1253 GKVNETKNILKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKSKMTPNGDEWPD 1317
.::..:.....|....:..:.:. .|||......:::...|| |.|.::|.| .|
Human 4583 SRLYWSTRYANRRCRYLCSIEEK----DGRPVFVIRIVEQGHEDL------VLSDISPKG-VW-- 4634
Fly 1318 LAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNTHWV 1382
.|.:..|.|...|: ||:.|:....|| ||:..:.:|.: |....:...|
Human 4635 --DKILEPVACVRKKS-----EMLQLFPAYLKG---EDLFGLTVSAV--------ARIAESLPGV 4681
Fly 1383 DHCT--TDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFNED 1445
:.|. |.|. .:....:..|..:.|||||:|......|:......:.....:|..||...
Human 4682 EACENYTFRY-----GRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQST 4741
Fly 1446 RSDEPTALTNHH--HNKLISKMQGISREARSNQRRLLTAFGSMGESELLKFNQLKFRKKQLKFAK 1508
.:.|..|..:.. |:| .|..|::.|.: |..:..|:
Human 4742 VTGELNAPYSKQFVHSK------------SSQYRKMKTEW-----------------KSNVYLAR 4777
Fly 1509 SAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCG 1573
|.|...||:|...|....|||||:|.:||..||:.:|..||:...| .|:||:|.:.:||||..|
Human 4778 SRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRG-VYMFRMDNDHVIDATLTG 4841
Fly 1574 NLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLEDE--KIPCLCGAQGC 1636
..||:|||||.|||.|:|:|.|...||:|.|.:.|...||:.|||||..||: ||||.|||..|
Human 4842 GPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNC 4906
Fly 1637 RGTLN 1641
|..:|
Human 4907 RKWMN 4911
| 
