Protein Alignment Set1 and nsd1b

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_005173940.1
• Gene: nsd1b / 564592
• ZFINID: ZDB-GENE-080519-2
• Length: 1873
• Species: Danio rerio
• Alignment Length: 1767
• Identity: 336/1767 - (19%)
• Similarity: 566/1767 - (32%)
• Gaps: 567/1767 - (32%)

  Fly   303 SDI-----SPEDSRD-------------ILIMTRERSRDSDSRP-----RDYCRSRERESFRDRK 344
            |||     ||:.|.|             ||....|.....|..|     |:.|.|....:.....
Zfish     6 SDICTSPPSPDFSLDSSSPFANGLHFESILFEDEEEDEVMDPEPVSQPERNLCGSTSDCTTNTNL 70

  Fly   345 RSHEKGRDQPREKREHYYNSSKDREYRGRDRDRSAEIDQRDRGSLKYCSRYSLHEYIETDVRRSS 409
            :::..|:.:.:..:.|   ||.:::...:|:.:|      |.|             :.|.|.|..
Zfish    71 KTNLDGKSRRKNSKAH---SSLEQDVVFQDKAKS------DSG-------------LSTLVSRPG 113

  Fly   410 NTISSYYSAS---SLPIASHGFNSCSFPSIENIKTWS--DRRAWTAFQPDFHPVQPPPPPPEEID 469
            ..:......|   :||...:         :|....|:  :||.|...|...||::
Zfish   114 GVLMKQKKKSKTKALPPVKY---------LEGEVIWAKFNRRPWWPCQVIIHPLE---------- 159

  Fly   470 NWDEEEHDKNSIVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFKGKTF 534
                             |...|::.| |........|::..:|.......:..|.|  ...|..|
Zfish   160 -----------------GVYHKMKEP-PDRTTRQYFLKTFGEPEEQAWVPERSTHI--FVGGYQF 204

  Fly   535 GNAPPFLQMDSSDSETDQG--------------------------KPEV------FSDVNSDS-N 566
            .|. ||::  .|..:.|:.                          ||.|      |..::.:: |
Zfish   205 NNL-PFVK--GSGHQRDENTRHSIPKRFLNSWSASVVAAEALLLEKPRVTSPSSAFKTISEETIN 266

  Fly   567 NSENK-------KRSCEKNNKVLHQPNEASDISSDEELIGKKDKSKLS-------LICEKEVNDD 617
            |:|.|       ..|....|..:.|.|..:.:..:.:...|| |..:|       |.|||
Zfish   267 NTEIKVSVPVDLPNSSFLINGAVIQNNHLNSLPHNRKSKNKK-KPTISHCRISEELNCEK----- 325

  Fly   618 NMSLSSLSSQEDPIQT-----KEGAEYKSIMSSYMYSH----------------------SNQNP 655
            .|.:.:|.|....|.:     :.....:.|.:.|:.::                      .||..
Zfish   326 GMIMDALDSPYSDIDSVPQIRRFPKSNEQISNHYVINYKQSSATPTVLPSTNDKDVKKNVENQGG 390

  Fly   656 FYYHASGYGHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNF-DSFS-KPYDYNKGALSDQNDG 718
            .::..:|.|. ::||   |.:.:.|    |:..:.|....... ||.| ||.|       :.|.|
Zfish   391 LWFSKTGKGQ-VNGI---SRAGIKS----VNCSFGKVSCKIKMPDSASMKPKD-------NHNTG 440

  Fly   719 IRQKVKQVIGYIVEELKQILKRDV-----NKRMIEITAFKHFE--TWWDEHTSKARSK------- 769
            :.        ::..|.|:.|.|.|     :.|:: ..|.|..|  .|..|.:|...:|
Zfish   441 LE--------HLSTEAKKALDRRVKCLPASSRLM-TRALKAMEDAEWTKESSSDLETKNCVSSFD 496

  Fly   770 -PLFE---------------------KADSTVNT------PLNCIKDTSYNEKNPDINLLINAHR 806
             |..|                     |.||.::|      .|.|.||..::.|:.|.:.|::  :
Zfish   497 SPSLETSDVHNSILLQKMPTAAIHDLKEDSKISTHAKLSSELLCCKDDEHSVKSEDESSLVS--Q 559

  Fly   807 EVADFQSYSSIGLRAAMPKLPSFRRIRKH-----PSPIPTKRNFLERDLSDQEEMVQRS------ 860
            ....|.|              |.|:...|     .||.|:    |..:|.|.:.|.:.|
Zfish   560 APCAFHS--------------STRKQNSHVNDLSSSPTPS----LHLNLKDMDNMNEISFKSLAN 606

  Fly   861 ----------------------------DSDKEDSNV-----------------EISDT----AR 876
                                        ||.::|.||                 .|||.    |.
Zfish   607 EHSGQPLSFHPDSNYKFSTFLMMLKDMHDSREKDGNVLVVEPLPTTELINEEPLLISDVKDEKAT 671

  Fly   877 SKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSSSTSSEA--EYEAIDCVEKAR--TSEE- 936
            ||.|...|.....|::|.:...||....:|...|....:|..:|  :|::.|.:..|.  ||:|
Zfish   672 SKQKKVKPKTNVMSENHLASTISKTAQRSSKKISLKKKTTDIKANIDYKSFDKLISAHRLTSKEA 736

  Fly   937 ------DSPRGYGQR--NLNQRTTTIRNRNLVGTMDVINVRNLC----SGSNE---FKKENVT-- 984
                  :.|:...|:  .::::|..|...|.:...:.::..| |    .|:|:   |..|..:
Zfish   737 ETNFSANVPKKRWQKFDQVSEKTVHIVEGNCIHKTERVSSEN-CDVSMDGTNKSCFFGPETTSNA 800

  Fly   985 --------------------KRTKKNIYSDTDEDNDRTLFPA---LKEKNISTILSDLEEISKDS 1026
                                ::..|.:...|:|.:.  ||.|   .|:|..|....:.::.|:..
Zfish   801 LECNQGNCQNTEAPTECKRIRKPSKRLIEWTEEYDQ--LFSAKKKAKKKPDSVTKIENQKCSEPV 863

  Fly  1027 CIGLDENGIEPTIL-----RKIP------------NTPKLNE-ECRRSL-----TPVPPPGY--- 1065
            ....||...:|.:.     |::|            :||.:|. .|:.|.     |..|||..
Zfish   864 AKTYDEVKQKPQVTEQDVSRRLPELQTPPPEDQSQSTPLINTLPCQESQVLSAETLTPPPEIIPS 928

  Fly  1066 ------NEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIE 1124
                  |.::::     :|.|....|.:..:|   |..::..|:..|...:.|...:.:::.:..
Zfish   929 PCDNISNRDQLQ-----RQNPVAVGDSVCLNS---KRQRKPTKKILESSIEAEPILIPKRKMKSM 985

  Fly  1125 KSLDKNLQSPNNIVKNNNSPRNK---------NDETRKT---------AISQTRSCFESASKVDT 1171
            |.......:.:.:.:.::..:||         :|...|:         |:.||.:. |||.....
Zfish   986 KICSSGHSTNSGVEQQSSKSKNKLSIESSDPPSDPMLKSTEMEIDVSPAVLQTINT-ESADDGSD 1049

  Fly  1172 TLVNIISVENDINEFGPHEE----GDVLTNGCNKMYTNSKGKT--KRTQSPVYSEGGSSQASQAS 1230
            ||....|...:.:||....|    .|.:.....::.....|.|  |....|:..:.|.....:.
Zfish  1050 TLRCSGSQMTESSEFYSEREENSQSDKVLLDSRRLSEEKGGSTSVKENVCPMCEKQGDLLLCEG- 1113

  Fly  1231 QVALEHCYSLPPHSVSLGDYPSGKV---NETKNI-----LKREAENI---------------AIV 1272
                :.|.:..|....|.:.|:||.   ..|..:     .||..|::               ...
Zfish  1114 ----QCCGAFHPQCTGLNEPPTGKFLCQECTSGVHSCFACKRLGEDVRRCMVPGCGKFYHGECAA 1174

  Fly  1273 SQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQN 1337
            |........|..:.|:........|.|...:|...........|...|.:...:|.......|.|
Zfish  1175 SHAPTVPLNRAFRCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSN 1239

  Fly  1338 EEMVILYTFLTKGIDAEDINFIKMSYL----------------DHLHKEPYAMFLNNTHWVDHCT 1386
               ::.....|......:...:.:|:.                ...|:|...:.:....|  :|.
Zfish  1240 ---IVCPNHFTPRKGCRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSW--YCN 1299

  Fly  1387 TDRA-----------------FWPPPSKKRRKD--DELIRHK------------------TGCAR 1414
            ..||                 .|.|......||  :.::|.|                  |..||
Zfish  1300 DCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQAR 1364

  Fly  1415 TEGFYKLDVREKAKH----KYHYAKANTEDS--------------FNEDRSDE--PTALTNHHHN 1459
            ...:.:.|...|.|.    ...|.||..|.:              ..|||.::  |........|
Zfish  1365 VFPYMEGDANSKEKMGKGVDSTYKKALDEAALRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVN 1429

  Fly  1460 KLISKMQGISRE----ARSNQRRLLTAFGSMG-ESELLK------------------FNQLKFRK 1501
            |...|:..||.:    .|.|.:  .|.....| :||.:.                  .||...::
Zfish  1430 KPFGKVLIISADLSEIPRCNCK--ATDENPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKR 1492

  Fly  1502 K--QLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDME 1564
            :  |::..::....|||..:..|.....:.||||::|.......|....:...||:.|:..:|.:
Zfish  1493 QYCQVETFRTLSRGWGLRCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKD 1557

  Fly  1565 TIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFP-LEDEKIP 1628
            .||||...||.|||:||.|.|||..:..|:..:.::.::|...|....|:|::|... |.:.|..
Zfish  1558 RIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGKTV 1622

  Fly  1629 CLCGAQGCRGTL 1640
            |.|||..|.|.|
Zfish  1623 CKCGASNCSGFL 1634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727	21/105 (20%)
		N-SET	1352..1496	CDD:463344	38/239 (16%)
		SET_SETD1	1490..1637	CDD:380946	45/167 (27%)
nsd1b	XP_005173940.1	PWWP	130..244	CDD:470613	23/155 (15%)
		PHD_SF	1098..1140	CDD:473978	8/46 (17%)
		PHD_SF	1145..1191	CDD:473978	6/45 (13%)
		PHD_SF	1193..1245	CDD:473978	8/54 (15%)
		PHD4_NSD1	1262..1301	CDD:277126	4/40 (10%)
		PWWP	1308..1403	CDD:470613	16/94 (17%)
		AWS	1454..1492	CDD:465559	5/37 (14%)
		SET	1494..1635	CDD:394802	45/141 (32%)
		PHD5_NSD1	1668..1710	CDD:277129
		C5HCH	1709..1758	CDD:465605