Protein Alignment Set1 and ash1l

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_005159540.1
• Gene: ash1l / 563799
• ZFINID: ZDB-GENE-030131-6101
• Length: 2988
• Species: Danio rerio
• Alignment Length: 2312
• Identity: 405/2312 - (17%)
• Similarity: 664/2312 - (28%)
• Gaps: 950/2312 - (41%)

  Fly     6 NINLVNNSSNSHDSSLANSKMPRNFKLLSDPQLVKCGTRLY---RYDGLMP-------------- 53
            |::.....|.||.|...|.....|......|..|.......   :.||::.
Zfish   217 NLHRPTTESKSHSSGKKNHVPQTNSAPAPSPPAVPPAATSQQDPKIDGILKTPQCNFLEGQKEQE 281

  Fly    54 -GDPSY--PTITPR-------DPRNPLIRIRARAVEPLMLLIPRFVIDSDYVGQPPAVEVTIVNL 108
             |..|:  ||:|.:       .|.:...:.:||.|.|.          ..:...||.:
Zfish   282 RGISSWGTPTVTEKLAQLIATCPPSKCPKPKARKVSPA----------PAHSSSPPLI------- 329

  Fly   109 NDNIDKQFLASMLDKCGTSDEINIYHHPITNKHLGIARIVFDSTKGARQFVEKYNQKSVMGKILD 173
             .|:.:...| |.::...|..:::...|..::..|            |.:..| |:.|::.|.
Zfish   330 -SNLQRPERA-MANRNTYSRAVHLAQPPPVSRPPG------------RPYGSK-NKDSILEKF-- 377

  Fly   174 VFCDPFGATLKKSLESLTNSVAGKQLIGPKVTPQWTFQQAALEDTEFIHGYPEKNGEHIKDIYTT 238
                 .|.:.|:..:.|:..|:|..      :...|...:||          .:|...:    ||
Zfish   378 -----SGTSKKEESDGLSKGVSGSS------STTTTTTSSAL----------SQNSSRL----TT 417

  Fly   239 QTNHEIPNRSRDRNWNRD--KERERDRHFKERSR-------HSSERSYDRDRGMRENVGT--SIR 292
            .|:   .|.|.|.| |.|  |.:.|..|....|.       .||..|.:|......|:|.  |:.
Zfish   418 TTS---TNESTDIN-NTDGMKSQSRLGHCPSHSSSAAASPPFSSSSSVERIGSTSCNIGLPGSLT 478

  Fly   293 RRRTFYRRRSSDISPEDSRDILIMTRERSRDSDSRPRDYCRSRERESFRDRKRSHEKGRDQPREK 357
            .|......|..|.|.:|..      |:|.:|:|| |||..:......         .|:...:|:
Zfish   479 SRPKASPSRIEDFSEKDKE------RDREKDTDS-PRDLSKGITPAI---------TGKQDAKER 527

  Fly   358 REHYYNSSKDREYRGRDRD---RSAEIDQRDRGSLKYCSRYSLHEYIETDVRRSSNTISSYY--- 416
                .:.|..|..||:...   ||...:.|..|             :.:....:..|||..|
Zfish   528 ----CSLSAPRNDRGKSSSPVKRSPNQESRVSG-------------VPSPAESTKCTISPSYPSG 575

  Fly   417 -SASSLPIASH-GFNSCSFPSIENIKTWSDRRA----WTAFQPDFHPVQPPPPPPEEIDNWDEEE 475
             |.|..|:... |..|.:.||.::.|....||.    ||......|......|          ..
Zfish   576 ASRSPPPLCDDTGAISPASPSEQDSKPLKKRRGRRPRWTKAVSRTHKSLHESP----------SN 630

  Fly   476 HDKNSIVPTHYGCMAKLQPPVPSNVNFATKL-QSVTQPNSDPGTVDLDTRIALIFKGKTFGNAP- 538
            |.:   :||          |:||.::|::.: :||.||.||..|...|:.|        |.::|
Zfish   631 HQQ---IPT----------PMPSGLSFSSPIRESVEQPLSDSYTSPEDSDI--------FDSSPK 674

  Fly   539 ----PFLQMDSSDSETDQGKPEVFSDVNSDSNNSENKKRSCEKNNKVLH---------------- 583
                |..:|...|:......|...:...|.|:..::|:   |::..|||
Zfish   675 KRGRPKTKMPRLDAPAHGCTPNKLAPSKSFSSLLKSKE---EQDPPVLHPEVDFNPPKMMARKRG 736

  Fly   584 -------------QP----NEASDISSDEE--------------LIGKKDKSK-------LS--L 608
                         ||    .|:.:.|..|:              :|||.:|.|       ||  |
Zfish   737 RPKRSPPTLPQETQPPTLAPESGEASVGEKPFRNKGNGQLIMKTIIGKINKMKTVKRKRLLSQIL 801

  Fly   609 ICEKEVNDDNMSLSSLSSQEDPIQTKE--------------GAEYKSIMSSYMY----------- 648
            :..|...:...|.|| .....|:.||.              |.:........:|
Zfish   802 LGPKPAEEQECSRSS-GPTGSPVATKPQSLTSLAATFGGKLGPQINVSKKGTIYMGKRRGRKPKT 865

  Fly   649 -----------------SHSNQNPFYYHA---SGYGHYL---SGIPSESASRL------FSNGAY 684
                             |.:..:|.::..   ....|.|   ...||.|.|:.      .|:.::
Zfish   866 STNPSPGAPTPPPEPFLSPNTSSPHHHQVQALQNQPHQLPPSEVFPSPSLSQSSGGQSPISDASF 930

  Fly   685 V--------------HSEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVIGY------ 729
            |              ||..:....||...:||.|...:..:.:.......||.....||
Zfish   931 VEPGSVHFSSHPHCSHSHQVHHSFSFPPPTFSAPSARSVASAATSTAHPSQKKSSCRGYHHHHHH 995

  Fly   730 ----------------------IVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPLF 772
                                  .:.|||:.....|::...|.|.........|.:::..|.
Zfish   996 YRQHYHYRKFSPPRPLLPTSPAPLSELKEATPSPVSESHSEETVPSDSGIGTDNNSTSDRG---- 1056

  Fly   773 EKADSTVNTPLNCIKD----------------------TSYNEKNPDINLLINAHREVADFQSYS 815
            |||.|....|...:..                      :|...:....::|:.......     |
Zfish  1057 EKAGSANGLPGVGVSQGMAGGLLMPGVIGPGIGTGIGLSSRGRRRHSSSVLLERPSPTP-----S 1116

  Fly   816 SIGLRA------AMPKLPS-----FRRIRKH---------PSPIPTKRNFLERDLSDQEEMVQRS 860
            .:|:||      :.|..||     .:...||         ||....||...:|.....:...:|.
Zfish  1117 PLGVRASPDPRRSHPAAPSSALVGHKEKHKHKCKRRGHGCPSYDKLKRQKRKRKKKYLQLRSRRQ 1181

  Fly   861 D----SDKEDSNVEISD------TARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSSS 915
            |    :|.::..|::||      |...::...:.:.........|||.|.|..      ||....
Zfish  1182 DPDFLADLDEICVQLSDIRISHRTPTLRLGSSIGLGAGAGPGRGSGLGSTRPS------SSLGGG 1240

  Fly   916 TSSEAEYEAIDCVEKARTSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINVRNL--------C 972
            |:                   ..|..|            .:|:|:.|:..||....        |
Zfish  1241 TN-------------------PPPHHY------------LHRDLLPTIFRINFSGYYSPHPAYPC 1274

  Fly   973 SGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTI---------LSD---------L 1019
            ...:..:|.::.|:              |...|.|:| :||.:         ||.         :
Zfish  1275 DSLHYVRKPDLKKK--------------RGRPPKLRE-SISEVPFVPGLGFPLSSGGFYHPSYGV 1324

  Fly  1020 EEISKDSCIGLDENGIEPTIL-----RKIPNTPKLNEECRRSLTPVPPPGY-----------NEE 1068
            ...|....:|.......|:.|     .:.|::...:.....|..|.|||.|           |..
Zfish  1325 PYSSTPLGLGYYRGYTPPSALYPHPHHQAPHSGPSHHVHSPSFPPPPPPSYVHHHHPSHLLLNPS 1389

  Fly  1069 EIKKKVDCKQK----------------PSFEYDRIYSDSEEEKEYQERRKRNTEY---------- 1107
            :..||   |.|                |:...:..:....:.|...:.|.|..|.
Zfish  1390 KFHKK---KHKLLRQEYLGGGRSSMLYPAMSSELSFGWHHKHKHRHKHRDRCGEEEGDDGGGVLG 1451

  Fly  1108 -------------MAQMEREFLEE-------QEKRIEKSLDKNLQSPNNIVKNNNS--PRNKNDE 1150
                         ..:.||..:|.       ::...:...:|...|.|:...::.|  .|.|..|
Zfish  1452 GIGGRGVGGEGLGAGRGERGSVESLQHCRFGRDGSADSRTNKQSASANSPSSSSTSSAERYKRKE 1516

  Fly  1151 TRKTAISQTRSCFESASK----VDT--------TLVNIISVENDINEFGPHEEGDVLTN-GCNK- 1201
            ...:.:..:|....:||:    ||:        |..:.:|.....:..|...||.|... .|::
Zfish  1517 ASMSCLGPSRLSLGTASRGHHPVDSWFRMGSSDTDYSKLSRNQSFSGSGAFSEGHVQNPVDCSES 1581

  Fly  1202 -------------------------MYTNSKGKTKRTQSPVYSEG-------------------- 1221
                                     ..|:.||...:...|:.|..
Zfish  1582 DEEDAASPIEEPEISHHTNLFASALSRTSLKGSRSKKGGPLESPSLSRLDRTVRRDRSTSSEKRE 1646

  Fly  1222 -----------GSSQASQASQ-------------VALEH-------------------------- 1236
                       |.|.....|:             ::|.|
Zfish  1647 IGNVSSLQNRVGQSSVPDVSEGLHHRHHHHHHPPLSLSHAASCLPHCTLDQPGNTAPLRPSSRQA 1711

  Fly  1237 -----------CYSLPPHSVSLGDYPSGKVNETKNILK--------REAENIAIVSQMTRTGPGR 1282
                       |...||..:|....|...:.....||:        |...|:     :.:.||||
Zfish  1712 SPSTCSSQPACCLDSPPSHLSHRPPPKNNLLHVNKILRAKKLQRQARTGNNM-----VKKRGPGR 1771

  Fly  1283 PRKDP------------------------------------------ICIQKKK----------- 1294
            |||:|                                          :..|:||
Zfish  1772 PRKNPLPSPPATPPPQTSEQDNHPLPERHRATALWEADTVVDAIEAVVQNQRKKGRKRKHWERET 1836

  Fly  1295 ----------------------------RDLAPRMSNVKSKMTPNGD-EWPDLAHKNVHFVPC-- 1328
                                        :..|.|..:|.|::...|. :|  |..:.||   |
Zfish  1837 EGGDEEEEDAEEERQVEDEEEEEDEEQEQQSAAREDDVMSRVRTEGSRQW--LTQEEVH---CFR 1896

  Fly  1329 --------------------------------------------------DMYKTRDQNEEMVIL 1343
                                                              |:|||.|...:::.|
Zfish  1897 SALEGKPDGSPERPGPATSEPTPNPSVTSQREKRVARPPKKKFQKAGLYSDVYKTDDPRSQLLQL 1961

  Fly  1344 ------YT-------------FLTKGIDAEDINFIKMSY-------LDHLHKEP----YAMFLNN 1378
                  ||             .:.|.:..:.|:| ::.|       .|.|:|.|    |....:|
Zfish  1962 KKEKLEYTPGEHDYGLLPAPIHVGKYLRQKRIDF-QLPYDILWLWKHDQLYKRPDVPLYKKIRSN 2025

  Fly  1379 THWVD-------HCTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKA 1436
            . :||       ..||.....|..|.::           ||           ::...::..||:.
Zfish  2026 V-YVDVKPLSGYEATTCNCRLPDDSSEK-----------GC-----------QDDCLNRMIYAEC 2067

  Fly  1437 NTEDSFNEDRSDEPTALTNHHHNKLISKMQGISREARSNQRRLLTAFGSMGESELLKFNQLKFRK 1501
            :.......|:.|          |:.|.|.:.:         :.|..|.:.|:.
Zfish  2068 SPSTCPCSDQCD----------NQRIQKHEWV---------QCLERFRAEGKG------------ 2101

  Fly  1502 KQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMI-----RPVVAD---LRETKYEAIG-----I 1553
                        ||:...:|:.|.:.:|||:|:::     |..:|.   |.:.|...:|     |
Zfish  2102 ------------WGIRTKQPLRAGQFIIEYLGEVVSEQEFRKYIASDCRLHQVKIPMLGENKKQI 2154

  Fly  1554 GSS------------YLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQ 1606
            |.|            |...:|...:||:.:.||.|||:||||.|||..:..::....:|.:::.:
Zfish  2155 GVSRMMEQYFSHSGHYCLNLDSGMVIDSYRMGNEARFVNHSCEPNCEMQKWSVNGVYRIGLFALK 2219

  Fly  1607 PIGINEEITYDY---KFPLEDEKIPCLCGAQGCRGTL 1640
            .|....|:||||   .|..|:::: |.||::||||.:
Zfish  2220 DINSGTELTYDYNFHSFNTEEQQV-CKCGSEGCRGII 2255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745	14/91 (15%)
		U2AF_lg	255..>386	CDD:273727	34/144 (24%)
		N-SET	1352..1496	CDD:463344	27/161 (17%)
		SET_SETD1	1490..1637	CDD:380946	45/174 (26%)
ash1l	XP_005159540.1	PHA03307	305..>647	CDD:223039	94/460 (20%)
		PHA03247	<480..906	CDD:223021	96/493 (19%)
		CytochromB561_N	<540..>674	CDD:480696	39/177 (22%)
		AWS	2037..2088	CDD:197795	13/82 (16%)
		SET_ASH1L	2091..2257	CDD:380951	51/190 (27%)
		COG5076	2281..>2500	CDD:227408
		Bromo_ASH1	2408..2513	CDD:99955
		PHD_ASH1L	2559..2601	CDD:277023
		BAH_polybromo	2633..2772	CDD:240068