Protein Alignment Set1 and kmt2ba

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_073787587.1
• Gene: kmt2ba / 560856
• ZFINID: ZDB-GENE-060503-376
• Length: 2945
• Species: Danio rerio
• Alignment Length: 1441
• Identity: 286/1441 - (19%)
• Similarity: 480/1441 - (33%)
• Gaps: 500/1441 - (34%)

  Fly   407 RSSNTISSYYSASSLPIASHGFNSCSFPSIENI-KTWSDRRAWTAFQPDFHP---VQPPPPPPEE 467
            ||..:|:....:.|.|::..|       :.||: .|.|.||  ....|...|   :..|.||...
Zfish  1799 RSGGSINPRSLSFSPPVSPLG-------ATENLMSTTSPRR--RGRPPSLSPSSIISGPSPPQAA 1854

  Fly   468 IDNWDEEEHDKNSIVPTHYGCMAKLQPPV-----------------PSNVNFATKLQS---VTQP 512
            :       ...:|.:|:......:||.|.                 |.....|..|:|   :..|
Zfish  1855 L-------RSPSSALPSTVHHSPRLQQPFTTSPHKTDKVVQDFLSEPEEAAGAPVLKSDHDLLSP 1912

  Fly   513 NSDPGTVDLDTRIALIFKGKTFGNAPPFLQMDSSDSETDQG--KPEVFSDVNSDSNNSENKKRSC 575
            :.||   |.|..:|.:...|.               |.|:.  ...|..|.:......|.::.:|
Zfish  1913 HFDP---DTDVAVASVLNAKL---------------EFDEALLNENVALDCDPQGAEGELEEEAC 1959

  Fly   576 EKNNKVLHQPNEASDISSDEELIGKKDKS---KLSLICEKEVNDDNMSLSSLSSQEDPIQ-TKEG 636
            :.|                   .|:||.|   ::.:..:.||.|..::.|......:|.: |:.|
Zfish  1960 KYN-------------------AGRKDLSSIAEMQMETDDEVADHYLNFSRTVVVCEPAKDTQTG 2005

  Fly   637 AEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNFDSF 701
            .   :::.:               ||....|.|..::|.|   ..|.....:..:.|.|......
Zfish  2006 L---TVLPN---------------SGSISQLDGADNDSES---DTGEANADDNTQEVGSSFLSQD 2049

  Fly   702 SKPYDYNKGALSDQNDGIRQKVKQVIGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKA 766
            ::|.     .::.||.|......|::                  ..||.         :.||:.:
Zfish  2050 TEPL-----KITGQNKGTTLGDGQLV------------------CTEIA---------NPHTADS 2082

  Fly   767 ---RSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHREVADFQSYS-SIGLRAAMPKLP 827
               .:||      .|.|....| ::...:....:.|||::|..:.::.|..| :.||.|.
Zfish  2083 VDENAKP------ETQNIEQVC-EEQEVSSLEDNANLLVDAGSDSSNQQEMSFTDGLNAT----- 2135

  Fly   828 SFRRIRKHPSPIPTKRNFLERDLSDQEEMVQRSDSDKEDSNVEISDTARS---KIKGPVPIQESD 889
                     :|:..|.:.|   ::.|||::..|:|......|.:.||:.:   .:.|.|    .|
Zfish  2136 ---------TPVVYKGSDL---IATQEEILAESESSAGSQEVFLDDTSGNFICTVDGRV----VD 2184

  Fly   890 SKSHTSGLNSKR--------------------------KGSASSFFSSSSSSTSSEAEYEAIDCV 928
            |..:|:.....|                          |.||:..|...:.|..::..:..|...
Zfish  2185 SPKNTADPEGSRDSVPINKENVVLNRALSPVEKPAAAVKSSATRTFHVVAPSMPAKRRFVTIQPG 2249

  Fly   929 EKARTSEEDSP------------------------------------RGYGQ------------- 944
            .:.:|.:...|                                    .|:|.
Zfish  2250 SQPKTFQMAMPVATSIPISVPINVVSTSPTFSVAPHGTQFTPSPVVINGFGAIPKEALKGRRIAI 2314

  Fly   945 ---------------------------------RNLNQRTTTIRNRNLVGTMDVINVRNLCSGSN 976
                                             :|....|..|.:.|......:..:..:..||
Zfish  2315 RIATPKQSLPHCVPGTPPTPQVLLVNRAGQILVKNPQNNTYQIPSANSPSYTQISQIARIIHGS- 2378

  Fly   977 EFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDEN-GIEP--- 1037
                 ||.:|....:          |:.|      :..:.:.|...|....|....| |..|
Zfish  2379 -----NVLQRPVPKV----------TVMP------VPQLQACLSRTSPARIISYSSNSGAAPPTQ 2422

  Fly  1038 TILRKIPNTPKLNEECRRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRK 1102
            .::|:||.:....:     |:.|.||      ::|.....:....|..::..| :....::|...
Zfish  2423 VLIRRIPQSFPGGQ-----LSGVSPP------LEKAGSISEGGQKELAQVIID-KAMASHREVAN 2475

  Fly  1103 RNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSP---RNKNDETRKTAISQTRSCF- 1163
            ..|...:.:.:....|.:|      ...|::..||:.|:.|.   :..:..|.:..:.:.::.|
Zfish  2476 ATTASPSLLGKRLSPESKK------SSTLRTQPNILANSRSQVRIKRVSSVTERIGVKRCKTDFL 2534

  Fly  1164 ---ESASKVDTTLVNIISV-----------------ENDINEFGPHEE-----------GDVLTN 1197
               ..:|:.|.:..|.:.:                 :||.::...||.           .|....
Zfish  2535 DQMAPSSQDDHSRSNRVRIKAPSVKEVLDFDGSFDPKNDDSKVAEHERITPKEPIATHANDSQDG 2599

  Fly  1198 GCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSL-PPHSVSLGDYPSGKVNETKNI 1261
            |.:.:.::..|.:. ..:| |: |.||.....|....|.|.|| .||
Zfish  2600 GKSHILSSKLGDSS-DWAP-YA-GWSSDEESPSPGKQEKCASLYQPH------------------ 2643

  Fly  1262 LKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPR--MSNVKSKMTPNGDEWPDLAHKNVH 1324
                     ::.|:|       .:|...::....|:|.:  |..|:...
Zfish  2644 ---------LIFQIT-------SEDGFSVEADSMDVAWKAVMDGVQEAR---------------- 2676

  Fly  1325 FVPCDM----YKTRDQNEEMVILY---TFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNTHWV 1382
             :.|.|    :.:.:....:.:|:   .||.:.:....: ..|..:..|.|:.|
Zfish  2677 -IGCRMEQLPFNSINGARVLGVLHDAVLFLLEQLQGASL-CQKHRFRFHQHEIP----------- 2728

  Fly  1383 DHCTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFNEDRS 1447
                               ::||..:..||||.|               .|.:.:|.|.||
Zfish  2729 -------------------EEELPENPNGCARAE---------------VYVRKSTFDMFN---- 2755

  Fly  1448 DEPTALTNHHHNKLISK---------MQGISREARSNQRRLLTAFGSMGESELLKFNQL-KFRKK 1502
                .|.:.|.....|:         |...||.|.|.:..:           .::|..| |..|:
Zfish  2756 ----FLASQHRQLPESRPCDDDEDDIMLKSSRRATSTELPV-----------AMRFRHLEKTSKE 2805

  Fly  1503 QLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMETII 1567
            .:...:||||..|||....|.|.||||||.|.:||.|:.|.||..|::.||| .|:||||...::
Zfish  2806 AVGVYRSAIHGRGLFCKRNIEAGEMVIEYAGNVIRAVLTDKREKYYDSKGIG-CYMFRIDDFDVV 2869

  Fly  1568 DATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLE--DEKIPCL 1630
            |||..||.||||||||:||||::||.:|.:|.|||::.:.|...||:|||||||:|  |.|:.|.
Zfish  2870 DATMHGNAARFINHSCDPNCYSRVINVEGQKHIVIFALRKIYRGEELTYDYKFPIEDADNKLHCN 2934

  Fly  1631 CGAQGCRGTLN 1641
            |||:.||..||
Zfish  2935 CGARRCRRFLN 2945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	25/152 (16%)
		SET_SETD1	1490..1637	CDD:380946	76/149 (51%)
kmt2ba	XP_073787587.1	None