Protein Alignment Set1 and LOC4577143

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_313355.5
• Gene: LOC4577143 / 4577143
• VectorBaseID: AGAMI1_013464
• Length: 851
• Species: Anopheles gambiae
• Alignment Length: 908
• Identity: 169/908 - (18%)
• Similarity: 286/908 - (31%)
• Gaps: 337/908 - (37%)

  Fly   950 RTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSD-------------------- 994
            ::|.::   .:..:..:..:|....:...|.||::|...:.:.||
Mosquito    57 KSTVVK---AISGVQTVRFKNELERNITIKLENLSKSFIETLQSDAKVMEAYLHKMHEQYKSPYN 118

  Fly   995 --TDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENGIE--PT---------------IL 1040
              |...|..|  |:.|.|                   |..||::  ||               ..
Mosquito   119 HGTSHSNKHT--PSRKRK-------------------LSPNGLQTSPTNNGETQRMKQAKIMDFF 162

  Fly  1041 RKIP----NTPKLN---EECRRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQ 1098
            ...|    ..|.|:   |..||...|.....::...|.|.....::.|...|::..:.:|.::..
Mosquito   163 HMSPPERITQPSLHASRERARRKSCPAAQGNFSGTHIPKPNGFPKRMSCSIDKVKKEVDESEDGS 227

  Fly  1099 ERRKRNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETRKTAISQTRSCF 1163
            .........:|.:.:|.....::.|:  ::.:.::|:  ..:::|......||.||..|
Mosquito   228 RFDVPTDTRLATINQEQATPDKQNIK--VECSDETPD--AMSSSSQVENGTETPKTTAS------ 282

  Fly  1164 ESASKVDT---TLVNIISVENDINEFGPHEEGDVLTNGCNKMYT----NSKGKTKRTQSPVYSEG 1221
               .||:.   |.|..::.:|              :||..|:.:    :.|..|.:|.:.:..|.
Mosquito   283 ---VKVENGTDTPVTPVARDN--------------SNGLLKVMSAAKPSPKTSTPKTTASIKVEN 330

  Fly  1222 GSSQASQASQVALEHCYSLPPHSVSLGDYPSGKVNETKNILKREAENIAIVSQMTRTGPGRPRKD 1286
            |:  .|.|:.|:.:....|  .:|.|...||.|...|
Mosquito   331 GT--VSPATPVSRDSSKGL--LNVKLAAKPSPKTPAT---------------------------- 363

  Fly  1287 PICIQKKKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGI 1351
                .::...|:...|..|.|.|..|.....:.            |:...::|..:        .
Mosquito   364 ----GERNSSLSAGKSTPKRKSTGGGSNSKQIK------------KSATTSKEYTV--------E 404

  Fly  1352 DAEDIN------FIKMSYLDHLHKEPYAMFLNNTHWVDHCTTDRAF----------WPPP-SKKR 1399
            :.|||.      |..:.:|.:..|:.....|||   |:.|....:|          |..| .:|.
Mosquito   405 NIEDIQLVGNSPFFLVKWLGYTSKDNTWEPLNN---VNSCAMLDSFLSAQMSLLEEWVEPLQEKI 466

  Fly  1400 RKDDE----------------LIRHK--------------------TGCART--EGFYKLDVREK 1426
            |...|                |:.||                    .|..:.  |...:|..||.
Mosquito   467 RSSPEYLESLERQGSKTYQEILLEHKEYDWDQLRADLIIMAKLWMNRGRNKLIWERITRLMCREL 531

  Fly  1427 AKHKYHYAK--ANTED--SFNEDRSD-EPT---ALTNHHH-----NKLI-----SKMQGIS---- 1469
            :     |||  ...|:  .|.:..:| |||   .:.|.|.     |...     ...:|||
Mosquito   532 S-----YAKRCEQLEELRRFEKHINDHEPTLRVVVENEHDLDAPPNNFTYLQGNIPAEGISIPND 591

  Fly  1470 -----------------------REARSNQRRLLTAFG----------SMGESELLKFNQLKFRK 1501
                                   |.|.|.::|||...|          |.|...|.:..|...:.
Mosquito   592 PPVGCECNPCTGRSTCCGKLSEGRFAYSVKKRLLLQPGAPIFECNKKCSCGPDCLNRVVQNGGKC 656

  Fly  1502 KQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDME-- 1564
            ....|.......||:.....|...:.:.||.|::|....|:.|..:|:|  :|.:|||.:|..
Mosquito   657 NLTLFKTPNGRGWGVRTNTVIYEGQYISEYCGEVISYDEAEKRGREYDA--VGRTYLFDLDFNGT 719

  Fly  1565 ---TIIDATKCGNLARFINHSCNPNCYAKVITIES----EKKIVIYSKQPIGINEEITYDYKF-- 1620
               ..:||.:.||:.||.||||:|||....:.|:.    ..::..::::.|.|.||:|::|..
Mosquito   720 DNPYTLDAARYGNVTRFFNHSCDPNCGIWSVWIDCLDPYLPRLAFFAQRRIEIGEELTFNYHAQV 784

  Fly  1621 ----------------PLE---------DEK---------------------IPCLCGAQGCR 1637
                            |::         :||                     ..||||:..||
Mosquito   785 SPNNVSINGGSGGGGPPMDGDSSTGGVVEEKPAENGDKATTANGSVRNTKGVTECLCGSANCR 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	50/253 (20%)
		SET_SETD1	1490..1637	CDD:380946	46/203 (23%)
LOC4577143	XP_313355.5	None