Protein Alignment Set1 and KMT2A

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_011541131.1
• Gene: KMT2A / 4297
• HGNCID: 7132
• Length: 4005
• Species: Homo sapiens
• Alignment Length: 1867
• Identity: 390/1867 - (20%)
• Similarity: 616/1867 - (32%)
• Gaps: 621/1867 - (33%)

  Fly   109 NDNIDKQFLASMLDKCGTSDEINIYHHPITNKHLGIARIVFDSTKGARQ---------FVEKYNQ 164
            |.:.|:......|...|.|:..:     |.|:|:|      .|::..||         |.||::.
Human  2426 NSSPDEDTEVKTLKLSGMSNRSS-----IINEHMG------SSSRDRRQKGKKSCKETFKEKHSS 2479

  Fly   165 KSVM----------GKILDVFCDPFGATLKKSLESLTNSVAGKQ--------LIG---------P 202
            ||.:          |.:...|.|          |.||....|::        .||         |
Human  2480 KSFLEPGQVTTGEEGNLKPEFMD----------EVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVP 2534

  Fly   203 KVTPQWTFQQAALEDTEFIHGYPEKNGEHIKDIYTTQTNHEIPNRSRDRNWNRDKERERDRHFKE 267
            |..|......|           .|......:.:..|.|..::.|.|:.:|..::.........:.
Human  2535 KAPPMQVEGSA-----------KELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIES 2588

  Fly   268 RSR----HSSERSYDRDRGMRENVGTSIRRRRTFYRRRSSDISPEDSRDILIMTRERSRDSDSRP 328
            .|.    .:||...|..........||.:..::    .:....|...|::::....:.::..|..
Human  2589 TSPTEPISASENPGDGPVAQPSPNNTSCQDSQS----NNYQNLPVQDRNLMLPDGPKPQEDGSFK 2649

  Fly   329 RDYCRSRERESFRDRK------------RSHEKGRDQPREKREHYYNSSKDREYRGRDRDRSAE- 380
            |.|    .|.|.|.|.            ||:.: .|.|      :|:||..:: ||:   ||||
Human  2650 RRY----PRRSARARSNMFFGLTPLYGVRSYGE-EDIP------FYSSSTGKK-RGK---RSAEG 2699

  Fly   381 -IDQRDRGSLKYCSRYSLHEYIETDVRRSSNTISSYYSASSLPIASHGF----NSCSFPSIENIK 440
             :|..|  .|.......|:.|      ..:.|:.|  |.....:|||..    ..|..|.|..:.
Human  2700 QVDGAD--DLSTSDEDDLYYY------NFTRTVIS--SGGEERLASHNLFREEEQCDLPKISQLD 2754

  Fly   441 -----TWSDRRAWTAFQPDFHPVQPPPPPPEE-------IDNWD---EEEHDKNSIV-----PTH 485
                 |.||.......:..   .|.|....:|       ||..:   |:||...|.|     |..
Human  2755 GVDDGTESDTSVTATTRKS---SQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKM 2816

  Fly   486 YGCMA-----------------------KLQPPVPSNVN----FATKLQSVTQPNS---DPGTVD 520
            ..|.:                       ::....||:.|    :.|:|......|:   |.|.:.
Human  2817 DNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNIL 2881

  Fly   521 LDTRIALIFKG----KTFGNAPPF-----------LQMDSSDSETDQGKPEVFSD---VNSDSNN 567
            ....:..:.|.    :..|.:|..           |.:| |:.|.|.|..||||.   .....::
Human  2882 PSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLD-SNREKDMGLFEVFSQQLPTTEPVDS 2945

  Fly   568 SENKKRSCEKNNKV-LHQPNEASDISSDEELIGKKDKSKLSLIC---EKEVNDDNMSLSSLSSQE 628
            |.:...|.|:..:: |..|::.|.:::....:..::.|:|::|.   ||.|.....|::  ||:.
Human  2946 SVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVA--SSES 3008

  Fly   629 DPI-------QTKEG-------------AEYKSI--MSSYMYSHSNQNPFYYHASGYGHYLSGIP 671
            ||.       .|.||             |::.|.  ..|....|.|......::|..|..:...|
Human  3009 DPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSP 3073

  Fly   672 ---------------SESASRLFSNGAYVHSEYLKAVASFNFDSFSKPYDYNKGALSDQN----- 716
                           |...|::.:........:||...             .|..:.:||
Human  3074 TVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPAT-------------EKLIVVNQNMQPLY 3125

  Fly   717 ------DGIRQKVK----------------QVIGYIVEEL------------KQILKRDVNKRMI 747
                  :|:.||::                .|:|.:...|            .|.|....:|.::
Human  3126 VLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLL 3190

  Fly   748 EITAFKHFETWWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHREVADFQ 812
            .::..:|.      |:..|.::..|....|  |.|...:...   :..||..||::...:..|..
Human  3191 PMSHHQHL------HSFPAATQSSFPPNIS--NPPSGLLIGV---QPPPDPQLLVSESSQRTDLS 3244

  Fly   813 ---SYSSIGLRAAMPKLPSFR---RIRKHPSPIPTKRNFLERDLSDQEEMVQRSDS--------- 862
               :..|.||:    |.|..|   |..|..:|..|..|....|:.....::..:.|
Human  3245 TTVATPSSGLK----KRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLL 3305

  Fly   863 DKEDSNVEISDTARSKIK---------GPVPI-------------QESDSKSHTSGLNSKRKGSA 905
            |....|.....|..:.||         .|.|:             ..|.....||.|.|   ||.
Human  3306 DLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTS---GSV 3367

  Fly   906 SSFFSSSSSSTSSEAEYEAIDCVEKARTSEEDSPR---GYGQRNLNQRTTTIRNRNLVGTMDVIN 967
            |...||||          .::.|....|:...|..   |:         .|:.|..|:||.|:.:
Human  3368 SGLASSSS----------VLNVVSMQTTTTPTSSASVPGH---------VTLTNPRLLGTPDIGS 3413

  Fly   968 VRNL----------------------------------------------------------CSG 974
            :.||                                                          .|.
Human  3414 ISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASP 3478

  Fly   975 SNE----FKKENVTK--RTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDEN 1033
            |.|    ::.::|.:  .:|..|:| :..|.|....|.:  .|.:      :.:...:.:||::|
Human  3479 SGEADEHYQLQHVNQLLASKTGIHS-SQRDLDSASGPQV--SNFT------QTVDAPNSMGLEQN 3534

  Fly  1034 -------GIEPTILRKIPNTPKLNEECRRSLTP-VPPPGYNEEEIKKKVDCKQKPSFEYDRIYSD 1090
                   ...||.....|::|...:   ||.:| ||.|            .|.||
Human  3535 KALSSAVQASPTSPGGSPSSPSSGQ---RSASPSVPGP------------TKPKP---------- 3574

  Fly  1091 SEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETRKTA 1155
                                        :.||.:..|||           .|..::|
Human  3575 ----------------------------KTKRFQLPLDK-----------GNGKKHK-------- 3592

  Fly  1156 ISQTRSCFESASKVDTTLVNIISVENDINEFGPHEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSE 1220
            :|..|:   |:|:...                |.:|...||:|     |.:.|.....|.....|
Human  3593 VSHLRT---SSSEAHI----------------PDQETTSLTSG-----TGTPGAEAEQQDTASVE 3633

  Fly  1221 GGSSQ--ASQASQVALEHCYSLPPHSVSLGDYPSGKVNETKNILKREAENIAIVSQMTRTGPGRP 1283
            ..|.:  ...|.|||:     ||  .|.:...|:.:....:.....|.|:......|......:.
Human  3634 QSSQKECGQPAGQVAV-----LP--EVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQK 3691

  Fly  1284 RKDPICIQKKKRDLAPRMSNVKSKMTPNG---------DEWPDLAHKNVHFVPCDMYKTRDQNEE 1339
            ||:.|..:|.|:.|...:|      :.:|         |.|..|.         |..:....|..
Human  3692 RKESITEKKPKKGLVFEIS------SDDGFQICAESIEDAWKSLT---------DKVQEARSNAR 3741

  Fly  1340 MVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNTHWVDHCTTDRAFWPPPSKKRRKDDE 1404
            :        |.:....:|.::|  |..|| :.....:.......||...:..:..|  :...:..
Human  3742 L--------KQLSFAGVNGLRM--LGILH-DAVVFLIEQLSGAKHCRNYKFRFHKP--EEANEPP 3793

  Fly  1405 LIRHKTGCARTEGFYKLDVREKAKHKYHY--AKANTEDSFNEDRSDEPTALTNHHHNKLISKMQG 1467
            |..|  |.||.|    :.:|:.|...:::  :|......:|.:..:|
Human  3794 LNPH--GSARAE----VHLRKSAFDMFNFLASKHRQPPEYNPNDEEE------------------ 3834

  Fly  1468 ISREARSNQRRLLTAFGSMGESELLKFNQLKFRKKQ-LKFAKSAIHDWGLFAMEPIAADEMVIEY 1531
              .|.:....|..|   ||.....::|..||...|: :...:|.||..|||....|.|.||||||
Human  3835 --EEVQLKSARRAT---SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEY 3894

  Fly  1532 VGQMIRPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIES 1596
            .|.:||.:..|.||..|::.||| .|:||||...::|||..||.||||||||.||||::||.|:.
Human  3895 AGNVIRSIQTDKREKYYDSKGIG-CYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDG 3958

  Fly  1597 EKKIVIYSKQPIGINEEITYDYKFPLED--EKIPCLCGAQGCRGTLN 1641
            :|.|||::.:.|...||:|||||||:||  .|:||.|||:.||..||
Human  3959 QKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 4005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745	21/100 (21%)
		U2AF_lg	255..>386	CDD:273727	29/148 (20%)
		N-SET	1352..1496	CDD:463344	25/145 (17%)
		SET_SETD1	1490..1637	CDD:380946	75/149 (50%)
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:366873
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2060..2107	CDD:461787
		FYRC	3705..3788	CDD:197781	17/110 (15%)
		SET_KMT2A_2B	3852..4005	CDD:380947	77/153 (50%)