Protein Alignment Set1 and Set8

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_650354.1
• Gene: Set8 / 41743
• FlyBaseID: FBgn0011474
• Length: 691
• Species: Drosophila melanogaster
• Alignment Length: 828
• Identity: 161/828 - (19%)
• Similarity: 268/828 - (32%)
• Gaps: 267/828 - (32%)

  Fly   900 KRKGSASSFFSSSSSSTSS-------------------EAEYEAI----DC----VEKARTSEED 937
            :|:..|....||||...||                   |.:|.|.    ||    |.:.....|.
  Fly     6 RRQRPAKEAASSSSGGASSGSGIPVDQALPLNVAGNLLEDQYFASPKRKDCRLMKVTQNGQLPEA 70

  Fly   938 SPRGYGQRNLNQRT--TTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDND 1000
            :...:.:.|...||  ..:..|:...|::           |.||.....|.::|.|:::
  Fly    71 TMMAHNKDNKAGRTIGVPLATRSQTRTIE-----------NFFKANAAAKDSQKTIHTE------ 118

  Fly  1001 RTLFPALKEKNISTILSDLEEISKDSCIGLDENGI---EPTILRKIPNTPKLNEECRRSLTPVPP 1062
                   ::.|:......|::...:..|.||:..:   :..|...:|...:::.:..:.|.
  Fly   119 -------EQLNLGNQELKLDDEELNGQIKLDDEVLKLADKQINENLPFADEVDAKAEQKLM---- 172

  Fly  1063 PGYNEEEIKKKVD----------CKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMA-------- 1109
                :||:::.|:          ....|.:::|.......::.......|:.||.:.
  Fly   173 ----DEELQQVVEELLFDGSSRASSNSPFYQHDMDVMQEIQQTPEIPHIKKVTEPLEGLGSLADF 233

  Fly  1110 QMEREFLEEQEKRIEKSLDKN--LQSPNNIVKNNNSPRNKNDETRKTAISQTRSCFESASKVDTT 1172
            |..|..|.:.......|...|  ||.|...:..:.:|      |:.::|...|| ||.|..|.::
  Fly   234 QTHRSALRDSHSSTHSSSTDNIFLQEPVLTLDIDRTP------TKASSIKINRS-FELAGAVFSS 291

  Fly  1173 LVNIISV-----ENDINEFGPHEEGDVLTNGCNKMYTNSK-------GKTKRTQSPVYSEGGSSQ 1225
            ..::::.     .|.|......:|...|.:.....:.:|.       |.|..|:||.   |...:
  Fly   292 PPSVLNACLNGRFNQIVSLNGQKEALDLPHFDLDQHDSSSCDSGVACGLTANTESPA---GQPRR 353

  Fly  1226 ASQASQVALEHCYSLPPHSVSLGDYPSGKVNETKNILKREAENIAIVSQMTRTG---PGRPRKDP 1287
            ...|:           ||.:..   ||    ..|..||       :...:.:.|   |..|||.|
  Fly   354 RKPAT-----------PHRILC---PS----PIKTALK-------VTGGICKVGSADPLSPRKSP 393

  Fly  1288 ---------ICIQKKKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVIL 1343
                     :...|.:|    |::..|    |.....|.|..      |....:.:.|::.:|:|
  Fly   394 RKLPTTTAAVAACKSRR----RLNQPK----PQAPYQPQLQK------PPSQQQQQQQDDIVVVL 444

  Fly  1344 YTFLTKGIDAEDIN-FIKMS-YLDHLHKEPYAMFLNNTHWVDHCTTDRAFWPPPSKKRRKDDELI 1406
            .....:|.|.:|:. .||.: ..::.:|.|.....|.      ........|.|.|.:.|..
  Fly   445 DDDDDEGDDEDDVRALIKAAEERENQNKAPATANSNK------AGMKTMLKPAPVKSKTKSK--- 500

  Fly  1407 RHKTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQGISRE 1471
                  ..|:|...|                            |.|.||
  Fly   501 ------GPTKGQPPL----------------------------PLAATN---------------- 515

  Fly  1472 ARSNQRRLLTAFGSMGESELLKFNQLKFRKKQLKFAKSAI-HDW--------------------- 1514
                           |..|:..|..:   ::.::..|:|: .:|
  Fly   516 ---------------GNREMTDFFPV---RRSVRKTKTAVKEEWMRGLEQAVLEERCDGLQVRHF 562

  Fly  1515 -----GLFAMEPIAADEMVIEYVGQMIRPVVADLRETKY---EAIGIGSSYLFRIDMETIIDAT- 1570
                 |:.|..|...:|.|:||||.:|....|..||.:|   |..|....|......:..||||
  Fly   563 MGKGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCIDATV 627

  Fly  1571 KCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDY 1618
            ..|.|.|.||||...|...||:.|:....:|:.:|..|...||:||||
  Fly   628 DTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	21/145 (14%)
		SET_SETD1	1490..1637	CDD:380946	46/160 (29%)
Set8	NP_650354.1	SET_SETD8	539..678	CDD:380926	42/137 (31%)