Protein Alignment Set1 and trx

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Alignment Length: 1382
• Identity: 274/1382 - (19%)
• Similarity: 460/1382 - (33%)
• Gaps: 383/1382 - (27%)

  Fly   490 AKLQP-PVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFKGKTFGNAPPFLQMDSSDSETDQG 553
            ||||| |........|::|   ||.:..|...|..:  |:|:..|...||..:        ..|.
  Fly  2498 AKLQPHPQQHQQQQQTQVQ---QPITVMGQNLLQPQ--LLFQSSTQTQAPQII--------LPQA 2549

  Fly   554 KPE-VFSDVNSDSNNSENKKR-SCEKNNKVLHQPNEA------------------SDISSDEELI 598
            :|: :.|.|..|.:..:..:. |.....:...||...                  :|.|.:..|.
  Fly  2550 QPQNIISFVTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLT 2614

  Fly   599 GKKDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGY 663
            .....|.|.::..:.:......:.:| .|...||...||:...       ..|||.|.....:|.
  Fly  2615 TTPSNSGLQMLTAQSLQAQPQVIGTL-IQPQTIQLGGGADGNQ-------PGSNQQPLILGGTGG 2671

  Fly   664 GHYLSGIPSESASR---LFSNGAYVHSEYL---KAVASFNFDSFSKPYDYNKGALSDQNDGIRQK 722
            |.  ||:...:.|.   |.:...|...|.:   ..::|..|.|.:.|     |.|| ||......
  Fly  2672 GS--SGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMP-----GMLS-QNASFSAT 2728

  Fly   723 VKQVI-------------GYIV-----------------EELKQILKRDVNKRMIEITAFKHFET 757
            ..||.             ||:|                 ..|:|..:.|...::::...|:.
  Fly  2729 TTQVFQASKIEPIVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQF--- 2790

  Fly   758 WWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLL--INAHREVADFQSYSSIGLR 820
                     :|.|    ..|..:|.::.........|.|.:..:  .||..:.|   ..|.:|
  Fly  2791 ---------QSVP----TSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAA---GISGVG-- 2837

  Fly   821 AAMPKLPSFRRIRKHPSP------IPTKRNFLERDLSDQEEMVQRSDSDKEDSNVE--------- 870
                |:|        |.|      :||       .:..|:..||..:|:.:.|.|:
  Fly  2838 ----KVP--------PQPQVVNKVLPT-------SIVTQQSQVQVKNSNLKQSQVKGKAASGTGT 2883

  Fly   871 --------ISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSS---STSSEAEYEA 924
                    .|...:.|.....||.:.:.|........|.:....|.......   ....:.....
  Fly  2884 TCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVV 2948

  Fly   925 IDCVEKARTSEEDSPRGYGQRNLNQ---------------------------------------- 949
            ::.|.|...|::..|....|:.|.|
  Fly  2949 VNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFV 3013

  Fly   950 -RTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDNDR---TLFPALKEK 1010
             ....:..:.|...:...:..:..|.||.....||....::...|.|.....|   .:.|..:.:
  Fly  3014 MEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQ 3078

  Fly  1011 NISTILSDLEEISKDSCIGLDENGIEPTILRKIPNTPKLNEECRRSLTPVPPPGYNEE------- 1068
            ..:.:.::...:|..:    ....:|..|:.::  |.....:|....:.:|.|.|..|
  Fly  3079 EPAPLSNECPVVSSPT----PPKPVEQPIIHQM--TSASVSKCYAQKSTLPSPVYEAELKVSSVL 3137

  Fly  1069 -----EIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLD 1128
                 ::......:::|..|  .||::...||......|.....:.|.:||.|.:|.......||
  Fly  3138 ESIVPDVTMDAILEEQPVTE--SIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLD 3200

  Fly  1129 KN---LQSPNNIVKNNNSPRNKNDETRKTAISQ-TRSC--FESASKVDTTLVNIIS--VENDINE 1185
            |:   ::..:..|........:.||....::.. |.:|  .|.:...:..:.:.||  ::|..|:
  Fly  3201 KHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTND 3265

  Fly  1186 FGPHEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDY 1250
                :..|.:..........|.|..:..:..:.:....|..::..:.|||.. ::...:..:.:.
  Fly  3266 ----DCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETA-AVEAAATYINEM 3325

  Fly  1251 PSGKVNETKNI-------LKREAENIAIVSQ----------MTRTGPGRPRKDPICIQKKKRDLA 1298
            ....|.:.|.:       |:|..|....|||          .|...|..|:.    ||:.|:...
  Fly  3326 ADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQP----IQEPKKMTG 3386

  Fly  1299 PRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDA------EDIN 1357
            |.:                            :|:.:.::.     :|:.:..|..      |.:.
  Fly  3387 PHL----------------------------LYEIQSEDG-----FTYKSSSITEIWEKVFEAVQ 3418

  Fly  1358 FIKMSY-LDHLHKEPYA----------------MFLNNTHWVDHCTTDRAFWPPPSKKRR----- 1400
            ..:.:: |..|.:.|.|                ..:.....|:.|:.    :.|...||.
  Fly  3419 VARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSK----YTPKYHKRNGNVST 3479

  Fly  1401 ----------------------------------KDDELIRHKTGCARTEGFYKLDVREKAKHKY 1431
                                              ..|||..:...|||.|
  Fly  3480 AANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCE--------------- 3529

  Fly  1432 HYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQGISREARSNQRRLLTAFGSMGESEL-LKFN 1495
            .|:..:..|.|        :.|.:.|      :.|.|....:.:...|:...|:.....: :|:.
  Fly  3530 PYSNRSEYDMF--------SWLASRH------RKQPIQVFVQPSDNELVPRRGTGSNLPMAMKYR 3580

  Fly  1496 QLK-FRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLF 1559
            .|| ..|..:...:|.||..||:..:.|.|.||||||.|::||..:.|.||..|::.||| .|:|
  Fly  3581 TLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIG-CYMF 3644

  Fly  1560 RIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLED 1624
            :||...::|||..||.||||||.|.||||:||:.|...|.|:|::.:.|...||:|||||||.||
  Fly  3645 KIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFED 3709

  Fly  1625 EKIPCLCGAQGCRGTLN 1641
            |||||.||::.||..||
  Fly  3710 EKIPCSCGSKRCRKYLN 3726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	27/206 (13%)
		SET_SETD1	1490..1637	CDD:380946	72/148 (49%)
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	13/124 (10%)
		SET_KMT2A_2B	3575..3726	CDD:380947	74/151 (49%)