Protein Alignment Set1 and ehmt1b

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_021324462.1
• Gene: ehmt1b / 402830
• ZFINID: ZDB-GENE-080515-3
• Length: 1295
• Species: Danio rerio
• Alignment Length: 1225
• Identity: 229/1225 - (18%)
• Similarity: 389/1225 - (31%)
• Gaps: 391/1225 - (31%)

  Fly   728 GYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYN 792
            |||:.::|:           :..:..|...|     |......|   ...|.::|.:.::.....
Zfish   112 GYILSKVKE-----------DTVSAPHRTNW-----SPTGGTTL---GHGTKSSPPSVLQSLDQG 157

  Fly   793 EKNPDINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQEEMV 857
            ..|...:...:.....|:.::.:.|..:...|.:...|:....|:...|.: .|.|:  ::|.:|
Zfish   158 SSNSGASQGPSLTERRAETETKNGIISKTPPPTVHRARKTMSRPASNQTLK-LLNRE--NKEPVV 219

  Fly   858 QRSDSDKEDSNVEISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSSSTSSEAEY 922
            .:.||..:...|:   ...|.|:..:|..::|:.|..:...:|.:..    ||..:|:.......
Zfish   220 VKDDSAGKPEAVQ---PQPSLIQNQLPQSQTDATSVPNTTPAKPQIE----FSLYASTVEPRPVS 277

  Fly   923 EAIDCVEKARTSEEDSPRGYGQRNL--NQRTTTIRNRNLVGTMDVIN-----------VRNLCSG 974
            .::..|.:.:      .|..|..:|  .::...::.|.::.....|:           ||
Zfish   278 PSVAAVSRKK------KRKMGTYSLVPKKKNKVLKQRTVLEMFQQISQSPPNPKPKEIVR----- 331

  Fly   975 SNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALK----EKNISTILSDLEEISKDS--CIGLDEN 1033
            .|..|.:|.:...:.....||:::.:.......|    |..|.:|...|||.|::|  |.| :|.
Zfish   332 VNGEKMDNESDEEESEEGEDTEDEEELVTEDGAKASHEEPRIPSISQPLEEESEESQDCEG-EEE 395

  Fly  1034 GIEPTILRKIPNTPKLNEECRRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEE---- 1094
            |.|..:..:.....|..::.:.....:.|....:.:.|.|.|   |.|.....|.|..|.:
Zfish   396 GDESDLSSESSLKKKWKKKAKGDHAWLRPSRKRKRKWKAKTD---KVSAPVTEIQSRPESQSAPS 457

  Fly  1095 ------KEYQE--------------RRKRNTEYMAQME----------------------REFLE 1117
                  |||:|              ...:||.....::                      ||.|.
Zfish   458 VPTAHRKEYKEVPLDSLNLAAQEALLTSQNTAASGSLQSTDADMVQELPLCSCRMETPKSREILT 522

  Fly  1118 EQEKR--IEKSLDKNLQSPNNIVKNNNSPRNKND-------ETRKTAISQTRSC----------- 1162
            ..:::  ..:|:|..|....:.|..:...|..|.       |..:|.:.:.:.|
Zfish   523 LADRKCMATESIDGQLSRCQSAVLKHEMMRPSNSVQLLVLCEDHRTGMVKHQCCPGCGFFCRAGT 587

  Fly  1163 -FESASKVD------TTLVNIISVENDINEFGPH------------------------------- 1189
             .|...:|:      .|..::::.::    |.||
Zfish   588 FMECQPEVNISHRFHRTCASVLNGQS----FCPHCGEEVSKAKEVTIAKADTTSTVPITHSSCIP 648

  Fly  1190 --EEG--DVLTNGCNKMYTNSKGKTKRT-QSPVYSEGGSSQ--ASQASQVALEHCYSLP----PH 1243
              .||  |..|.|..::....:||...| ..|..|:..|..  .|:|..||:.....||    |.
Zfish   649 STSEGKADTTTGGSTRLSVLGEGKANSTLPKPSESQDTSLSLVGSKARSVAMAAAPGLPLPPGPP 713

  Fly  1244 SVSLGD--------------------YPSGKVNETKNIL-----------KREAEN------IA- 1270
            ..:|..                    |.|.|..|.:.:|           |.|::|      :|
Zfish   714 KETLQSVLLALDAEKPKKLRFHPKQLYISAKQGELQKVLLMLVDGIDPNFKMESQNKRTPLHVAA 778

  Fly  1271 ------IVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSN--------------VKSKMTPNGDEW 1315
                  :...:.:.|...    .:|.:.::..|.....|              :.|.....|...
Zfish   779 EAGHQDVCHMLVQAGANL----DMCDEDQRTPLMEACENNHLETVRYLLRAGAIVSHKDVEGSTC 839

  Fly  1316 PDLAHKNVHF-------------VPCD------------MYKTRDQ---------------NEEM 1340
            ..||.||.||             :.|.            .||..||               .||.
Zfish   840 LHLAAKNGHFSIVQHLLSAGLVDINCQDDGGWTAMIWATEYKHVDQVKLLLSKGADINIRDKEEN 904

  Fly  1341 VILY------------TFLTKGIDAEDINFIKMSYLDHLHKEP----YAMFLNNTHWV------- 1382
            :.|:            .|||...|...:|....|.|....:|.    ..:||:....|
Zfish   905 ICLHWAAFSGCVEIAEIFLTAKCDLNTMNIHGDSPLHIASREGRLDCVNLFLSRGADVNLKNKEG 969

  Fly  1383 ----DHCTTDRAFWP--PPSKKRRKDDELIRHKTGCAR-------TEGFYKLDV-------REKA 1427
                :.|:.....|.  ..:||:|:    ...|.|...       ..|:.|:.|       .|..
Zfish   970 ETPMECCSHSSKVWNALQANKKQRE----ANRKAGATEKLLNKDIARGYEKVPVPCVNAVDSEPC 1030

  Fly  1428 KHKYHYAKANTEDS-FNEDRSDEPTALTNHHHNKLISKMQGISREARSNQ----------RRLLT 1481
            ...|.|...:...| .|.|::     :|  |....:.|....|......|          .|||.
Zfish  1031 PDNYKYVPDSCVTSPLNIDKN-----IT--HLQYCVCKDDCSSASCMCGQLSLRCWYDKESRLLP 1088

  Fly  1482 AFGSMGESELLKF------------------NQLKFRKKQLKFAKSAIHDWGLFAMEPIAADEMV 1528
            .|.:  |...|.|                  |.|:.|   |:..|:.:..||:..::.|.....|
Zfish  1089 EFSN--EEPPLIFECNHACSCWRTCKNRVVQNGLRTR---LQLFKTQMMGWGVKTLQDIPQGTFV 1148

  Fly  1529 IEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMET----IIDATKCGNLARFINHSCNPNCY- 1588
            .||||::|....||:||        ..||||.:|.:.    .:||...||::|||||.|.||..
Zfish  1149 CEYVGEIISDAEADVRE--------NDSYLFSLDSKVGDMYCVDARFYGNISRFINHHCEPNLLP 1205

  Fly  1589 AKVITIESEKK---IVIYSKQPIGINEEITYDYKFPLEDEK---IPCLCGAQGCR 1637
            .:|.|...:.:   |..::.:.|...:|:.:||.....|.|   ..|.||:..|:
Zfish  1206 CRVFTSHQDLRFPHIAFFACKNISAGDELGFDYGDHFWDVKGKLFNCKCGSSKCK 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	36/203 (18%)
		SET_SETD1	1490..1637	CDD:380946	49/175 (28%)
ehmt1b	XP_021324462.1	EHMT_ZBD	503..632	CDD:411018	18/132 (14%)
		ANKYR	720..973	CDD:440430	40/256 (16%)
		ANK repeat	739..765	CDD:293786	5/25 (20%)
		ANK repeat	767..800	CDD:293786	3/36 (8%)
		ANK repeat	802..833	CDD:293786	3/30 (10%)
		ANK repeat	835..867	CDD:293786	8/31 (26%)
		ANK repeat	869..900	CDD:293786	4/30 (13%)
		ANK repeat	902..933	CDD:293786	7/30 (23%)
		ANK repeat	935..966	CDD:293786	6/30 (20%)
		SET	1033..1262	CDD:394802	65/248 (26%)