Protein Alignment Set1 and Ehmt1

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_006233681.2
• Gene: Ehmt1 / 362078
• RGDID: 1307588
• Length: 1309
• Species: Rattus norvegicus
• Alignment Length: 1369
• Identity: 257/1369 - (18%)
• Similarity: 452/1369 - (33%)
• Gaps: 417/1369 - (30%)

  Fly   544 DSSDSETDQGKPEVFSDVNSDSNNSENKKRSCEKNNKVLHQPNEASDISSDEELIGKKDKSKLSL 608
            |...:|...|:..:.:|  .::|.      ||||:..:.| ||.......:.....::..:::|.
  Rat    49 DEGSTEKQAGETPMAAD--GETNG------SCEKSGDISH-PNAPKHTQENTRASPQEGTNRVSR 104

  Fly   609 ICEKEVN--DDNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMY--------SHSNQNPFYYHASGY 663
            :.|..|:  |..:...:..:.:|.:||       |::.|..|        ....:.|...::|..
  Rat   105 VAENGVSERDTEVGKQNHVTADDFMQT-------SVIGSNGYFLNKPALQGQPLRTPNTLNSSLP 162

  Fly   664 GHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNFDSFSKPYDYNKGALSDQND------GIRQK 722
            ||....:|. .||:..:..|...:            ..:.|....:|: :|..|      |...:
  Rat   163 GHAAKTLPG-GASKCRTPSALPQT------------PTTAPTVPGEGS-ADTEDRKPTASGTDVR 213

  Fly   723 V--------KQVIGY--------IVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPL 771
            |        |.::|.        .|::.|: .|.|:|:.:.|....:...|:...|.|..:::..
  Rat   214 VHRARKTMPKSILGLHAASKDHREVQDHKE-PKEDINRNISECGRQQLLPTFPALHQSLPQNQCY 277

  Fly   772 FEKADS-TVNTPLNCIKDTSYNEKN--------PDINLLINAHREVAD-FQS--YSSIGLRAAMP 824
            .....| |...|.......|..:|.        |.....:...|.|.: |:|  :|::|.:....
  Rat   278 MATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKV 342

  Fly   825 KLPSFRRIR------------------------KHPSPIPTKRNFLERDLSDQEEMVQRSDSDKE 865
            ...|...:.                        :..:..||:.:...::...:.:...:.|.|.|
  Rat   343 LDDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSE 407

  Fly   866 DSNVEISDTARSKIKGPVPIQESDSKSHTSGLNS--KRKGSASSFF------------SSSSSST 916
            :.. |..||...:..|    .|||..|.:|....  ||:|...|.:            ...||..
  Rat   408 EEQ-ESPDTGEDEDGG----DESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSML 467

  Fly   917 SSEAEYEAIDCVEKARTSEEDSPRGYGQRNLNQRTTTIR--------NRNLVGTMDVINVRN--- 970
            .|||...:...:|:|...:.   .||.:.:|:.....:|        |..|....||:....
  Rat   468 GSEACKSSPGSMEQAALGDS---AGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHE 529

  Fly   971 --LCSGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSD--LEEISKDSCIGLD 1031
              |||...|                            ..|.:.|||:.::  :...|.|..:|..
  Rat   530 VPLCSCRME----------------------------TPKSREISTLANNQCMATESVDHELGRC 566

  Fly  1032 ENG-IEPTILRKIPNTPKL-----------NEECRRSLTPVPPPGY-----NEEEIKKKVDCKQK 1079
            .|. ::..::|.....|.|           ..:|      .|..||     |      .::|:.:
  Rat   567 TNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQC------CPGCGYFCTAGN------FMECQPE 619

  Fly  1080 PSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKS-----------LDKNLQS 1133
            .|..: |.:.|...       |..|..|......|..:.:|..|.|:           .:|:|.:
  Rat   620 SSISH-RFHKDCAS-------RVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAA 676

  Fly  1134 PNNIVKNNNSPRN-KNDETRKTAISQTRSCFESA------------------SKVDTTLVNIISV 1179
            .........|... ..||..::.::|...||:.|                  ..:::.|:.:.|.
  Rat   677 EGRADTTTGSIAGAPEDEKSQSTVTQAPECFDPAGPAGFVRPTSGFSQGPGKETLESALIALDSE 741

  Fly  1180 ENDINEFGPHE------EGD------VLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQV 1232
            :.....|.|.:      :|:      :|.:|.:   .|.|.:.:..:||:::      |::|..|
  Rat   742 KPKKLRFHPKQLYFSARQGELQKVLLMLVDGID---PNFKMEHQSKRSPLHA------AAEAGHV 797

  Fly  1233 ALEHCYSLPPHSVSLGDYPSGKVNETKNILKREAEN--IAIVSQMTRTGPGRPRKDP-------I 1288
            .:  |:.|    |..|........:.:..|...|||  :..|..:.:.|.....||.       :
  Rat   798 DI--CHML----VQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHL 856

  Fly  1289 CIQKKKRDLAP-RMSNVKSKMTPNGD-EWPDL----AHKNVHFVPCDMYKTRD----QNEEMVIL 1343
            ..:|...|:.. .:||.:..:....| .|..:    .:|:|..|...:.|..|    .|||.:.|
  Rat   857 AAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICL 921

  Fly  1344 YTFLTKG-ID-AE-------DINFIKMSYLDHLH----KEPY---AMFLNNTHWVDHCTTDRAFW 1392
            :.....| :| ||       |::.:.:.....||    :..|   .:||:
  Rat   922 HWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS--------------- 971

  Fly  1393 PPPSKKRRKDDELIRHKTG-----CAR----------------------------------TEGF 1418
                   |..|..:::|.|     ||.                                  ..|:
  Rat   972 -------RDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGY 1029

  Fly  1419 YKLDV-------REKAKHKYHYAKANTEDS-FNEDRSDEPTALTNHHHNKLISKMQGIS------ 1469
            .::.:       .|.....|.|...|...| .|.||:     :|:..:...:......:
  Rat  1030 ERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRN-----ITHLQYCVCVDDCSSSTCMCGQL 1089

  Fly  1470 --REARSNQRRLLTAFGSMGESELLKF------------------NQLKFRKKQLKFAKSAIHDW 1514
              |.......|||..| :|.|..|: |                  |.|:.|   |:..::....|
  Rat  1090 SMRCWYDKDGRLLPEF-NMAEPPLI-FECNHACSCWRNCRNRVVQNGLRAR---LQLYRTQDMGW 1149

  Fly  1515 GLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMET----IIDATKCGNL 1575
            |:.:::.|.....|.||||::|....||:||.        .||||.:|.:.    .|||...||:
  Rat  1150 GVRSLQDIPLGTFVCEYVGELISDSEADVREE--------DSYLFDLDNKDGEVYCIDARFYGNV 1206

  Fly  1576 ARFINHSCNPNCYAKVITIESE----KKIVIYSKQPIGINEEITYDYKFPLEDEK---IPCLCGA 1633
            :|||||.|.||.....:.:..:    .:|..:|.:.|...|::.:||.....|.|   ..|.||:
  Rat  1207 SRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGS 1271

  Fly  1634 QGCR 1637
            ..||
  Rat  1272 PKCR 1275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	34/231 (15%)
		SET_SETD1	1490..1637	CDD:380946	48/175 (27%)
Ehmt1	XP_006233681.2	EHMT_ZBD	527..657	CDD:411018	30/177 (17%)
		ANKYR	731..987	CDD:440430	55/292 (19%)
		ANK repeat	785..814	CDD:293786	9/40 (23%)
		ANK repeat	816..847	CDD:293786	6/30 (20%)
		ANK repeat	849..881	CDD:293786	4/31 (13%)
		ANK repeat	883..914	CDD:293786	6/30 (20%)
		ANK repeat	916..947	CDD:293786	8/30 (27%)
		ANK repeat	949..980	CDD:293786	7/52 (13%)
		SET_EHMT1	1047..1277	CDD:380933	65/247 (26%)