Protein Alignment Set1 and Set2

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Alignment Length: 1651
• Identity: 306/1651 - (18%)
• Similarity: 539/1651 - (32%)
• Gaps: 501/1651 - (30%)

  Fly   371 RGRDRDRSAEIDQRDRG--------SLKY-------------------CSRYSLHEYIETDVR-- 406
            |||.|.|..::.....|        |||:                   |.|.|..:.|:.|||
  Fly    16 RGRGRGRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDL 80

  Fly   407 --------------RSSNTISSYYSASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHP 457
                          |..:..|:.:|.|....||...::.:..:.......:..|.::.|:.....
  Fly    81 LNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQS 145

  Fly   458 VQPPPPPPEEIDNWDEEEHDKNSIV------PTHYG------CMAKLQPPVP--------SNVNF 502
            :.||||||..::.:.:....::.||      |:..|      .||.|.|..|        |.:..
  Fly   146 LPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLAD 210

  Fly   503 ATKLQSVTQPN-SDPGTVDLDT------------------------RIAL-------IFKGKTFG 535
            |..:.:|..|: ||..|....|                        |::|       ..:....|
  Fly   211 AAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSG 275

  Fly   536 NA---------PPFLQ-----------------MDSSDSETDQGKPEVFSDVNSDSNNSENKKRS 574
            |:         ||.||                 |..::..:|.....:|.::.::|...|.::
  Fly   276 NSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQ-- 338

  Fly   575 CEKNNKVLHQPNEASDISSDEELIGKKDKSKLSLICEKEVNDDNMSLSSLS------SQEDPIQT 633
             |:...|..:|.:..||  |.|| .|::.:.     :.|.:.|.:.:..||      |.:|..:.
  Fly   339 -EEGRPVEVEPQDLIDI--DMEL-AKQEPTP-----DPEEDLDEIMVEVLSGPPSLWSADDEAEE 394

  Fly   634 KE----------GAEYKSIMSSYMYSHSNQNPFYYHASGYGHYL----SGIPSESASRLFSNGAY 684
            :|          |.|..:...|.....|.::.....:|..|..|    :.|.:||:.::......
  Fly   395 EEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEES 459

  Fly   685 VHSEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVI--------GYIVEELKQILKRD 741
            ...|....:.....|:.|:         |:....:...::.::        ..:|:|..:||  |
  Fly   460 QDQEEQHILIDLIEDTLSE---------SEVTSSVSPTIEHMVVEEVVVEENQLVDEADEIL--D 513

  Fly   742 VNKRMIEITAFKHFETWWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHR 806
            ..:..:....|..     .::.:.:.:|.:||   ..|.|...|      .|..|        ..
  Fly   514 SKQEFVIKKVFSE-----SDNIAASLNKDIFE---PKVETKATC------GEVVP--------RP 556

  Fly   807 EVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQE--EMVQRSDSDKEDSNV 869
            |:.....|.:.|:.|.:.|.....:        ||.....|..|||:.  |...:.:||.:.:.|
  Fly   557 EMVTEDVYITEGIAATLEKSAVVTK--------PTTEMIAETKLSDEVVIEPPLKDESDPKQTEV 613

  Fly   870 EISDT------------------------------ARSKIKGPVPIQESDSKSHTSGLN------ 898
            |:.::                              ....:.|||.::.|.|....|..|
  Fly   614 ELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPL 678

  Fly   899 ---SKRKGSASSFFSSSSSSTSSE---------------AEYEAIDC----------------VE 929
               :.::.|..:.....:|::|.|               ||.|.:.|                .|
  Fly   679 KTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPE 743

  Fly   930 KARTSEEDSPRGYGQRNLNQRTTTIRNRNL-VGTMD--------------VINVRNLCSG----- 974
            |. .:|..|.:.....|..:.:..|.::.: .|.|:              .::.:..|:.
  Fly   744 KP-VAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAK 807

  Fly   975 ---SNEFKKENVTKR--TKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENG 1034
               |.:..||.:.|:  .|:...:..|..:..||  ..|.|:.:.....|:.:.|.|.....|:.
  Fly   808 QKESGKSAKEAILKKETEKEKSSAKLDSSSPNTL--DKKGKDTAQWSPQLQTLPKSSTKPPQESA 870

  Fly  1035 IEPTILRK-IPNTPKLNEE---CRRSLTPVPPP-----------GY------------------- 1065
              |:::.| ..|.|...||   .::.|:...||           |:
  Fly   871 --PSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRL 933

  Fly  1066 ---NEEEIKK----------------------KVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNT 1105
               |::::||                      |.....|.|...:.:|.||..    .||....:
  Fly   934 DEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPN----LERNSSPS 994

  Fly  1106 EYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETRKTAIS------------- 1157
            ...||......:.:..:::|.::....:.....|:..|..:.:..||:.|.|
  Fly   995 SDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKR 1059

  Fly  1158 ----QTRSCFESASKVDTTLVNI---------ISVENDINEFGPHEEG------DVLTNGCNKMY 1203
                :|.|..:..||:|.....|         |.|......|..|.:.      |.|.....|..
  Fly  1060 NGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKR 1124

  Fly  1204 TNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDYPSGKVNETKNILK----- 1263
            ...:|  |.:.|...|...||.|||.:                    |..|..::..||.
  Fly  1125 GRKEG--KESLSRQNSLDSSSSASQGA--------------------PKKKALKSAEILSAALLE 1167

  Fly  1264 -REAENIAIVSQMTR----TGPGRPRKDPI------------CIQKKKRDLAPR---MSNVKSKM 1308
             ..:|:.:..|:|:|    |.|.....:|.            .:::.|.|...|   ...||.:.
  Fly  1168 TESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREA 1232

  Fly  1309 TPNGDEWPD-LAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPY 1372
            .|..||:.. :|:............|:...|:.....|.|.   :.|....::.|:  .:.::|.
  Fly  1233 DPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLK---ELETGGGVRRSH--RIKQKPQ 1292

  Fly  1373 AMFLNNTHWVDHCTTDRAFWPPPSKKR----------RKDDELIRHKTGCARTEGFYK---LDVR 1424
            .                   |..|:.|          ..|::|.......|..|.|.:   |:..
  Fly  1293 G-------------------PRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTF 1338

  Fly  1425 EKAKHKYHYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQG-ISREARSNQRRLLTAFGSMGE 1488
            :..|..::...........|.:.|  ..||..      .:.|| :|..|....|.|:...|.:..
  Fly  1339 QLLKENFYRCARQVSQENAEMQCD--CFLTGD------EEAQGHLSCGAGCINRMLMIECGPLCS 1395

  Fly  1489 SELLKFNQLKFRKKQ---LKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEA 1550
            :.....|: :|::.|   .:..::.....|:.|...|...|.::||||::|.....:.|:..|..
  Fly  1396 NGARCTNK-RFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSK 1459

  Fly  1551 IGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEIT 1615
            ......|...:..|.:||||..||::|:|||||:||...:..|:..|.:|..:|.:||...||||
  Fly  1460 DRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEIT 1524

  Fly  1616 YDY---KFPLEDEKIPCLCGAQGCRG 1638
            :||   ::..:.::  |.|.|..|||
  Fly  1525 FDYQYLRYGRDAQR--CYCEAANCRG 1548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727	5/14 (36%)
		N-SET	1352..1496	CDD:463344	24/157 (15%)
		SET_SETD1	1490..1637	CDD:380946	45/152 (30%)
Set2	NP_572888.2	valS	<709..832	CDD:237855	18/123 (15%)
		AWS	1358..1410	CDD:197795	13/60 (22%)
		SET_SETD2	1410..1551	CDD:380949	45/141 (32%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404