Protein Alignment Set1 and trr

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Alignment Length: 1707
• Identity: 310/1707 - (18%)
• Similarity: 522/1707 - (30%)
• Gaps: 659/1707 - (38%)

  Fly   417 SASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHPVQPPPPPPEEIDNWDEEEHDKNSI 481
            ||::||:::....:........::..||:.|........:...||||||::  ...::.|....:
  Fly   902 SATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQ--QQQQQLHQPQQL 964

  Fly   482 VPTHYGCMAKLQPPVPSNVNFATKLQS-----------VTQPNSDPG------------------ 517
            .|:.:        .|...|...:|..|           ||:..|.|.
  Fly   965 QPSPH--------QVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNV 1021

  Fly   518 TVDLDTRIA----LIFKGKTFGNAPPFLQMDSSDSETDQGKPEVFSDVNSDSNN----------- 567
            |:.:.|:.|    |..|.|....:.|..|.|  :|..:|.:|.:.|:..:.:..
  Fly  1022 TISISTKQAAPKELQMKPKAVAMSLPMEQGD--ESLPEQAEPPLHSEQGATAAGVAPHSGGPLVS 1084

  Fly   568 ---SENKKRSCEKNNKVLHQPNEASDISSDEELIGKKDKSKLSL---ICEKEVNDDNMSLSSLSS 626
               :.|.........|:..:|             |:..|.||.:   :.||::........|.|.
  Fly  1085 AQWTNNHLEGGVATTKIPFKP-------------GEPQKRKLPMHPQLDEKQIQQQAEIPISTSL 1136

  Fly   627 QEDPIQTKEGAEYK----SIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESAS-RLFSNGAYVH 686
            ...|  |.:|...|    |.:::|:..                  ||:|:|:.. :..|.|....
  Fly  1137 PTTP--TGQGTPDKVQLISAIATYVKK------------------SGVPNEAQPIQNQSQGQVQM 1181

  Fly   687 SEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVIGYIVEELKQILKRDVNKRMIEITA 751
            ...::|..              :|.||.|..|      |:.|:...               :|.|
  Fly  1182 QAQMQATM--------------QGHLSGQMSG------QISGHAAG---------------QIPA 1211

  Fly   752 FKHFETWWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHREVADFQSYSS 816
            ..|.:.   :|.......|..::.....|.|           :|..|.|.:.....|
  Fly  1212 QMHLQV---QHQLHMAVHPQQQQQQLHQNQP-----------QNATIPLPVTGQGAV-------- 1254

  Fly   817 IGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQEEMVQRSDSDKEDSNVEISDT--ARSKI 879
                               |.|:||    :|....||.:..:|.......:|:.....  |...:
  Fly  1255 -------------------PIPVPT----MESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDL 1296

  Fly   880 KGPVP----IQESDSKSHTSGLNSKRKGSASSFFSSS--------SSSTSSEAEYEAIDCVEKAR 932
            .||:|    :|.:.....|..:.....|:.....|:.        .:||.:.:.......|.|..
  Fly  1297 TGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFS 1361

  Fly   933 TSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINVRN--LCSGSNEFKKENVTKRTKKNIYSDT 995
            ..|||.. .:.::.|    |.||....:..::....||  ...||||...............:.:
  Fly  1362 KVEEDHD-AFTEKLL----THIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGS 1421

  Fly   996 DEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENGIEPTILRK-----IPNTPKLNEECR- 1054
            .......|....:...:|..|..||:     |.|        |:|.:     :|..|.|.:..|
  Fly  1422 SSAGGGKLKGGSRGWPLSRHLEGLED-----CDG--------TVLGRYGRVNLPGIPSLYDSERF 1473

  Fly  1055 -------------RSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTE 1106
                         ||.:|...||     .:|.:......:..||:.:| :..|:..:||..|:..
  Fly  1474 GGSRGLVGGSARTRSPSPAESPG-----AEKMLPMSSIQNDFYDQEFS-THMERNPRERLVRHIG 1532

  Fly  1107 YMAQMERE---FLEEQEKRIEKSLDKNLQSPNNIVKNNNSP------------------------ 1144
            .:.....|   .:|.:......:|.:..:.|..|:.|.||.
  Fly  1533 AVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPL 1597

  Fly  1145 -RNKNDETRKT-------------------------AISQTRSCFESASKVDTTLVNIIS----- 1178
             |:..:|.|||                         .::...|..|:.:.|...|.|::.
  Fly  1598 LRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPAL 1662

  Fly  1179 ----VENDINE------FGPHEEGDV--------LTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQ 1225
                :|:.|..      ....:|..|        :::|..:...|.:.|..|:...|....| .:
  Fly  1663 TCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATG-LR 1726

  Fly  1226 ASQASQVALEHCY-------------SLPPHSV-------------------------------- 1245
            ..:.|..|||...             |:||..|
  Fly  1727 VPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGG 1791

  Fly  1246 -----SLGDYP----SGKVNETKNILKREAENIAIVSQMTRTGPGRPRKDPI---CIQK------ 1292
                 |.||.|    :......:.::|:|.|:   ..:.|.:.||.|...|.   ||.|
  Fly  1792 SAVKSSNGDSPGSFCASSTAPAEMVVKQEPED---EDEKTPSVPGNPTNIPAQRKCIVKCFSADC 1853

  Fly  1293 KKRDLAPR----------------MSNVKSKMTPNG----------------------------- 1312
            ...|.||.                ::|...:...:|
  Fly  1854 FTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNF 1918

  Fly  1313 --DEWPDL----------------------------------AHK-------------NVHFVPC 1328
              |:|..|                                  .|:             :::.:||
  Fly  1919 DVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPC 1983

  Fly  1329 DM------YKT--------------------------------------------------RDQN 1337
            .:      ||.                                                  ||:|
  Fly  1984 AIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDEN 2048

  Fly  1338 EEM--VILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNTHWVDHC--TTDRAFWPPPSKK 1398
            .::  |:.|:.|:..:...::.|:.:..|.....|.:    :..|::...  ...|.:|......
  Fly  2049 RQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAF----HTPHYIYPIGYKVSRYYWCVRRPN 2109

  Fly  1399 RRKDDELIRH-----KTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFNEDRSDEPTA------ 1452
            ||     .|:     :.||             |.:.:.....|..::...|.|...|:|
  Fly  2110 RR-----CRYICSIAEAGC-------------KPEFRIQVQDAGDKEPEREFRGSSPSAVWQQIL 2156

  Fly  1453 ---------------------------LTNHHHNKLISKMQGI---------------------- 1468
                                       ||.....:::..:.||
  Fly  2157 QPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAI 2221

  Fly  1469 --SREARS--NQRRLL---------TAFGS-----MGESELL---------------KFNQLKFR 1500
              |..||:  .||:||         || ||     |..|..:               |.:|.|..
  Fly  2222 NPSGAARTEPKQRQLLVWRKPHTQRTA-GSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKM 2285

  Fly  1501 KKQLK----FAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRI 1561
            |::.:    .|:|.|...||:|...|....|:|||:|::||..|:::||.:||:...| .|:||:
  Fly  2286 KQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRG-IYMFRL 2349

  Fly  1562 DMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLEDE- 1625
            |.:.::|||..|.|||:|||||||||..:::.::.:.:|:|::|:.|...||::|||||.:|||
  Fly  2350 DEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDES 2414

  Fly  1626 -KIPCLCGAQGCRGTLN 1641
             ||||.|||..||..:|
  Fly  2415 HKIPCACGAPNCRKWMN 2431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	35/238 (15%)
		SET_SETD1	1490..1637	CDD:380946	65/167 (39%)
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	8/103 (8%)
		FYRN	2067..2118	CDD:461787	9/59 (15%)
		FYRC	2126..2215	CDD:197781	9/88 (10%)
		SET_KMT2C_2D	2278..2430	CDD:380948	67/152 (44%)