Protein Alignment Set1 and Ash1l

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_063137913.1
• Gene: Ash1l / 310638
• RGDID: 1306350
• Length: 3000
• Species: Rattus norvegicus
• Alignment Length: 1993
• Identity: 370/1993 - (18%)
• Similarity: 633/1993 - (31%)
• Gaps: 674/1993 - (33%)

  Fly    54 GDPSYPTITPRDPRNPLIRIRARAVEPLMLLIPRFVIDSDYVGQPPAVEVTIVNLNDNIDK-QFL 117
            |:.:.|:.:|....|||.|   ...|....|:|..::.:....|       :..::::|.| ||.
  Rat   592 GESNLPSSSPTVSVNPLTR---NPPETSSQLVPNPLLLNSTAEQ-------MEEISESIGKNQFT 646

  Fly   118 ASMLDKCGTSDEINIYH----HPIT--------------NKHLGIARIVFDSTKGARQFVEKYNQ 164
            |.       |..:|:.|    |.|:              :.||.|:||
  Rat   647 AE-------STHLNVGHRSLGHSISIECKGIDKELNESKSTHLDISRI----------------- 687

  Fly   165 KSVMGKILDVFCDPFGATLKKSLESLTNSVAGKQL--IGPKVTPQWTFQQAALEDTEFIHGYPEK 227
            .|.:||...:..|....|:..|:.:.|:..:.|..  :|....|....|.|....|.| ...|.|
  Rat   688 SSSLGKKPSLASDSGIHTITPSVVNFTSLFSNKPFLKLGAVAAPDKHCQVAESLSTSF-QSKPLK 751

  Fly   228 NGEHIKDIYTTQTNHEIPNRSRDRNWNRDKERERDRHFKERSRHSSERSYDRDRGMRENVGTSIR 292
            ..:..|..:|     ::..||..|: .:..:.||...||..|..|...|.:..:.|: .:|.|..
  Rat   752 KRKGRKARWT-----KVVARSTCRS-PKGLDLERSELFKNVSCSSLSNSSEPAKFMK-TIGASSF 809

  Fly   293 RRRTFYRRRSSDISPEDSRDILIMTRERSRDSDS--------------------------RPRD- 330
            ....|.:||...:|...:..:.::.........|                          ||:.
  Rat   810 VDHDFLKRRLPKLSKSSAPSLALLADSEKASHKSFITHKLSSSMCVTSDLLSDIYKPKRGRPKSK 874

  Fly   331 ---------------------YCRSRERE------------SFRD--------RKRSHEK----- 349
                                 ..:|:|.:            ||:.        :||...|
  Rat   875 EMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQSLSVSPFPKKRGRPKRQMRS 939

  Fly   350 ---------------GRDQPR--EKREHYYNSSKD---REYRGRDRD------------------ 376
                           ..:.|.  |.....:.||.|   .|.:.:|.|
  Rat   940 PVKMKPPVLSVAPFVATESPSKLESESENHRSSSDFFESEDQLQDTDDLEDSHRQSVCSVSDLEM 1004

  Fly   377 -RSAEIDQRDRGSL-----------KYCSRYS-LHEYIETDVRRSS---------NTISSYYSAS 419
             ...:|.:|:.|.|           |...|.. |::.:.:.|..|:         ||:||..:..
  Rat  1005 EPDKKISKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLAATF 1069

  Fly   420 SLPIAS------------------------HGFNSCSFPSIENIKTWSDRRAWTAFQPDFHPVQP 460
            ...:..                        :|..|.|..|:..::..:.:.|.:|......|:.|
  Rat  1070 GSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLP 1134

  Fly   461 PPPPPEEIDNWDEEEHDKNSIVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSDP--------G 517
            .|....||         ..|.:.:.....:..|.||.|:..|       .:|:|.|        |
  Rat  1135 SPASSSEI---------LPSPICSQSSGTSGGQSPVSSDAGF-------VEPSSVPYLHVHSRQG 1183

  Fly   518 TVDLDTRIALIFKGKTFGNAPPFLQMDS------------------SDSETDQGKPE---VFSDV 561
            ::.....:....||:. ..:||.|..:|                  |:|.:|:..|.   :.:|.
  Rat  1184 SMIQTLAMKKAAKGRR-RLSPPTLLPNSPSHLSELTSLKEATPSPVSESHSDETIPSDSGIGTDN 1247

  Fly   562 NSDSNNSE----NKKRSCEKNNKVLHQPNEASDISSDEELIGKKDKSKLSLICEKEVND----DN 618
            ||.|:.:|    .|||.....:..|..|..::.::|.:|    |.|.|    |::..:|    |.
  Rat  1248 NSTSDRAEKFCGQKKRRHSFEHISLIPPETSTVLNSLKE----KHKHK----CKRRSHDYLSYDK 1304

  Fly   619 M---------SLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHS----------------NQNPFYY 658
            |         ....|.:::||....|..|..|.:|....:|.                |.|.||.
  Rat  1305 MKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYT 1369

  Fly   659 HAS---GYGHYL--------SGIPSESASRLFSNGAYVHSEYLKAVASFNFDSFSKPYDYNKGAL 712
            |.|   ...||:        .|.|.:....: :...::||......::..:.|:..|  |:...|
  Rat  1370 HPSFPLDPLHYIRKPDLKKKRGRPPKMREAM-AEMPFMHSLSFPLSSTGFYPSYGMP--YSPSPL 1431

  Fly   713 SDQNDGIRQKVKQVIGY----------------IVEELKQILKRDVNKRMIEITAFKHFETWWDE 761
            :....|        :||                ....|...........::..|.:
  Rat  1432 TAAPIG--------LGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAGHLLLNPTKY--------- 1479

  Fly   762 HTSKARSKPLFEKAD-STVNTPLNCIKDTSYNEKNPDI--NLLI-------NAHREVADFQSYSS 816
              .|.:.|.|.::|. :|..|||  :..::|....|::  ..::       :.|||....|...|
  Rat  1480 --HKKKHKLLRQEAFLTTSRTPL--LSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSEQPQVS 1540

  Fly   817 IGLRAAMPKLPSFRRIR--------------KH------PSPIPTKRNFLERDLSDQEEMVQRSD 861
            :...::...|.|.:|.|              ||      |...|:| :.:.|    :|:.|.|..
  Rat  1541 MDTGSSRSVLESLKRYRFGKDTVGDRYKHKEKHRCHMSCPHLSPSK-SLINR----EEQWVSREP 1600

  Fly   862 SDKED--------SNVEISDTARS-KIKGPVPIQE-SDSKSH----TSGLNSKRKGSASS----- 907
            |:...        ..::.|:::.| .:.|..|..| :.|..|    ||.:.|.|..:.:|
  Rat  1601 SESSSLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHMNLFTSAIGSCRVSNPNSSCRKK 1665

  Fly   908 ------FFSSSSSSTSSEAEYEAIDCVEKA------RTSEEDSPRGYGQRNLNQRTTTIRNRNLV 960
                  .|....::.|.....|.:...|:|      ..|..|.|        :||::...|
  Rat  1666 LTDSPGLFPVQDTALSRPHRKEPLPSTERAIQSLAGSQSASDKP--------SQRSSESTN---- 1718

  Fly   961 GTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKD 1025
                       ||.:.:......|..|...|.|.:..      ..|..:.::..:|..:  :..|
  Rat  1719 -----------CSPTRKRSSSESTSSTVNGIPSRSPR------LVASLDDSVDCLLQRI--VQHD 1764

  Fly  1026 SCIGLDENGIEPTILRKIPNTPKLNEECRRSLTPVPPPG--YNEEEIKKKVDCKQKPSFEYDRIY 1088
            ....:::||..|......|              |...||  |::|....|.|....|:...|...
  Rat  1765 EQESVEKNGDAPITTVSAP--------------PSSSPGHSYSKERTLGKSDSLLVPAVPSDSCN 1815

  Fly  1089 SDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEK--------SLDKNLQSPNNIVK------ 1139
            |.....::...|...:     .::|..:|..:::..|        :..|||...|.|:|
  Rat  1816 SIPLLSEKLASRCSPH-----HIKRSVVEAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQR 1875

  Fly  1140 ----NNNSPRNKNDETRKTAISQTRS--CFESASKVDTTLVNIISVENDINEFGPHEEGDVLTN- 1197
                .||..:.:....||..:....|  .|::|..|:..|       |:..|...|...|.:|:
  Rat  1876 QARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPEL-------NEGEEVSLHLSPDTVTDV 1933

  Fly  1198 ------GCNKMYTNSKG----------KTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVS 1246
                  ..|....:.||          :|::.|..|..|  ..|.:..|.:.
  Rat  1934 IEAVVQSVNLNSEHKKGWKRKNWLLEEQTRKKQKTVPEE--EEQENNKSFIE------------- 1983

  Fly  1247 LGDYPSGKVNETKNILKREAENIAIVSQMTRTGPGRPRKD--PICIQKKKRDLAPRMSNVKSKMT 1309
                   |..|..:.|:..||            |..|..:  |:.....:...|||..  |.|..
  Rat  1984 -------KPVEIPSPLETPAE------------PSEPESNLQPVLALIPREKKAPRPP--KKKYQ 2027

  Fly  1310 PNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAM 1374
            ..|             :..|:|||.|....::             .:...|:.|....|:  |.:
  Rat  2028 RAG-------------LYSDVYKTTDPKSRLI-------------QLKKEKLEYTPGEHE--YGL 2064

  Fly  1375 FLNNTHWVDHCTTDRAFWPPP------SKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHY 1433
            |                 |.|      .:::|.|.:|              ..|:..:.||...|
  Rat  2065 F-----------------PAPIHVGKYLRQKRIDFQL--------------PYDILWQWKHNQLY 2098

  Fly  1434 AKANT---------------------EDSFNEDRSDEPT--ALTNHHHNKLI----SKMQGISRE 1471
            .|.:.                     ..:.|..:.|:.|  ...:...|::|    |.......|
  Rat  2099 KKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTCPCGE 2163

  Fly  1472 ARSNQRRLLTAFGSMGESELLKFNQLKFRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMI 1536
            ...|||        :...|.::..: :||.::        ..||:...||:.|.:.:|||:|:::
  Rat  2164 QCCNQR--------IQRHEWVQCLE-RFRAEE--------KGWGIRTKEPLKAGQFIIEYLGEVV 2211

  Fly  1537 RPVVADLRETKYEAIGIGSS-YLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKI 1600
            ..  .:.|....|.....|. |...:|...:||:.:.||.||||||||:|||..:..::....:|
  Rat  2212 SE--QEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRI 2274

  Fly  1601 VIYSKQPIGINEEITYDY---KFPLEDEKIPCLCGAQGCRGTL 1640
            .:|:.:.:....|:||||   .|.:|.::: |.||.:.|||.:
  Rat  2275 GLYALKDVPAGTELTYDYNFHSFNVEKQQL-CKCGFEKCRGII 2316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745	21/110 (19%)
		U2AF_lg	255..>386	CDD:273727	34/242 (14%)
		N-SET	1352..1496	CDD:463344	26/176 (15%)
		SET_SETD1	1490..1637	CDD:380946	44/150 (29%)
Ash1l	XP_063137913.1	None