Protein Alignment Set1 and Nsd3

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_038950324.1
• Gene: Nsd3 / 290831
• RGDID: 1308980
• Length: 1444
• Species: Rattus norvegicus
• Alignment Length: 1509
• Identity: 278/1509 - (18%)
• Similarity: 473/1509 - (31%)
• Gaps: 571/1509 - (37%)

  Fly   411 TISSYYSASSLPIASHGFNSCS--FPSIENIKTWSDRRAWTAFQP-DFH---------------- 456
            :||.|.:.:..|..|...|..:  |.::.|            |.| |::
  Rat    76 SISLYETQTKYPPYSQYPNGSANGFGAVRN------------FSPTDYYHSEIPNTRPHEILEKP 128

  Fly   457 -PVQPPPPPPEEIDNWDEEEHDKNSIVPTHYGCMAKLQPPVPSNV--------NFATKLQSVTQP 512
             |.||||||                ::|..       .||||..|        ....|:....|.
  Rat   129 SPPQPPPPP----------------LLPPP-------PPPVPQTVIPKKTGSPEIKLKITKTIQN 170

  Fly   513 NSDPGTVDLDTRIALIFKGKTFGNAPPFLQMDSSDSETDQGKPEVFSDVNSDSNNSENKKRSCEK 577
            ..:            :|:....|:    |..:...||..:.|.|...:....|:..|:.:....|
  Rat   171 GRE------------LFESSLCGD----LLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEERK 219

  Fly   578 NNKV-------LHQPNEASDISSDEELIGKKDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQTKE 635
            ::||       .::|||..|.:.::                              .:|:|: .||
  Rat   220 SHKVPKLEPEGQNRPNERVDPAPEK------------------------------PREEPV-LKE 253

  Fly   636 GAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRLFSN-GAY--------------V 685
            ....:.|:||...:.::               :|:..:....::|. |.|              |
  Rat   254 AVPVQPILSSVPTTETS---------------TGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEV 303

  Fly   686 HSEY-LKAVASFNFDSFSKPYDYNKGALSDQNDGIRQK-VKQVIGYIVEELKQILKRDVNKRMIE 748
            |::. .:....::...||.         ..:...:.:| |::..|:  |:.:::|.....:
  Rat   304 HTKINTRGAREYHVQFFSN---------QPERAWVHEKRVREYKGH--EQYEELLAEAAKQ---- 353

  Fly   749 ITAFKHFETWWDEHTSKARS-KPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHREVADFQ 812
              |..|.|      ..|.|. :|..|:|..                   ||.:   ||.|.|...
  Rat   354 --ASNHSE------KQKIRKPRPQRERAQW-------------------DIGI---AHAEKALQM 388

  Fly   813 SYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQEEMVQRSDSDKEDSNVEISDTARS 877
            :      |....:..:|..|.|.|...|                          |..:.|.|:::
  Rat   389 T------REERVEQYTFIYIDKQPEESP--------------------------SQAKKSVTSKA 421

  Fly   878 KIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSSSTSSEAEYEAIDCVEKARTS-EEDSP-- 939
            ::|.|       .:..:.| ||:.:.:::...:|..|||....:      .::..|| |||.|
  Rat   422 EVKKP-------RRPRSVG-NSQPEQTSAGEVASPQSSTDPRRQ------SQRRHTSVEEDGPPP 472

  Fly   940 -----RGYGQRNLNQRTTTIRNRNLVGTMDV--INVRNLCSGSNEFKKENVT---KRTKKNIYSD 994
                 |....|.....:.|:..    |::|:  .|:..:......|..:|.|   |...:.:||.
  Rat   473 VKIAWRTAAARKSLPASITMHK----GSLDLHKCNMSPVVKIEQVFALQNATGDGKFIDQFVYST 533

  Fly   995 TDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENGIEPTILRKIPNTP-KLNEECRRSLT 1058
            ....|...:                      |..|.|         |.|.::| :.||:...|.:
  Rat   534 KGIGNKTEI----------------------SVRGQD---------RLIISSPSQRNEKSTPSAS 567

  Fly  1059 PVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRI 1123
            |......:...::||   :|:.|.   |..|:||:..|...::|...|          ::.|...
  Rat   568 PPEATSGSAGPVEKK---QQRRSI---RTRSESEKSTEVVSKKKIKKE----------QQVETSP 616

  Fly  1124 EKSLDKNLQSPNNIVKNNNSPRNKNDETRKTAISQTRSCFESASKVDTTLVNIISVENDINEFGP 1188
            :.||...||...:.:.::..|..|  .:|.:...:|.||    :..||         :|.:..||
  Rat   617 QASLKTGLQKGASEISDSCKPLKK--RSRASTDVETASC----TYRDT---------SDSDSRGP 666

  Fly  1189 HEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQA------------------------ 1229
             .:|.|             |..|:..||  |....:.||.|
  Rat   667 -SDGQV-------------GFGKQVDSP--SAAADADASDAQSVDSSLSRRGVGLSKKDTVCQVC 715

  Fly  1230 -----SQVALEH--CYSLPPHSVSLGDYPSGKVN----ET------------KNILKREAENIAI 1271
                 |.||.|.  |....|..:.|...|.|:..    ||            |:: ||.:.::.
  Rat   716 ENTGDSLVACEGECCRHFHPECLGLAAVPEGRFTCEECETGQHPCFSCKVSGKDV-KRCSVSVC- 778

  Fly  1272 VSQMTRTGPGR------PRKDPICIQKKK---------------RDL--APRMSNVKSKMTPNGD 1313
                     |:      .||.|..|.:.|               :|:  |.:...:|....|...
  Rat   779 ---------GKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMKCLRCPIAY 834

  Fly  1314 EWPD--LAHKNV----HFVPCDMYKTRDQNEEMV-ILYTFL-TKGI---DAEDINFIKMSYLDH- 1366
            .:.|  :|..:|    |.:.|..:..|..:...: :.:.|: .:|:   |..|..|...:|..|
  Rat   835 HFGDACVAAGSVSVSSHILICSNHSKRSSHSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHY 899

  Fly  1367 -----------------------------------------LHKEPYAMFLNNTHWVDHCTTDRA 1390
                                                     .|.|..::.:....|  :|...:|
  Rat   900 LLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCW--NCNDCKA 962

  Fly  1391 ------------------FWPPPSKKRRK------------------------------------ 1401
                              :||..:...|.
  Rat   963 GKKLHYKQIVWVKLGNYRWWPAETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVHQGRVFPY 1027

  Fly  1402 ---DDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFN---EDRSDEPTALTNHHHNK 1460
               |......:|...:|   :|..:.|.|| ::...||..|....   |..|.:|....:...||
  Rat  1028 VEGDTNFAEGQTSINKT---FKKALEEAAK-RFQELKAQRESKEALEIEKTSRKPPPYKHIKANK 1088

  Fly  1461 LISKMQ----GISREARSNQRRLLTAFGSMG----ESELL-KFNQLK----------------FR 1500
            :|.|:|    .:|...|.|.:.     |...    |||.| :.:|.:                |.
  Rat  1089 VIGKVQIQVADLSEIPRCNCKP-----GDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCFT 1148

  Fly  1501 KK---QLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRID 1562
            |:   ..:..|:....|||.....|...|.|.||||::|......||..:.....:.:.|:..:.
  Rat  1149 KRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVT 1213

  Fly  1563 METIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFP-LEDEK 1626
            .:.||||...||.:||:||||||||..:..|:..:.::.:::...|....|:|::|... |.:.:
  Rat  1214 KDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGR 1278

  Fly  1627 IPCLCGAQGCRGTL 1640
            ..|.|||..|.|.|
  Rat  1279 TVCHCGADNCSGFL 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	39/254 (15%)
		SET_SETD1	1490..1637	CDD:380946	46/167 (28%)
Nsd3	XP_038950324.1	PWWP_NSD3_rpt1	275..404	CDD:438991	29/179 (16%)
		PHD1_NSD3	711..753	CDD:277119	9/41 (22%)
		PHD2_NSD3	759..805	CDD:277122	9/56 (16%)
		PHD_SF	806..858	CDD:473978	9/51 (18%)
		PHD4_NSD3	925..960	CDD:277128	4/36 (11%)
		PWWP_NSD3_rpt2	967..1061	CDD:438994	10/97 (10%)
		AWS	1112..1150	CDD:465559	6/37 (16%)
		SET_NSD3	1152..1293	CDD:380989	44/141 (31%)
		PHD5_NSD3	1330..1372	CDD:277131
		C5HCH	1371..1420	CDD:465605