Protein Alignment Set1 and EZH2

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_011514185.1
• Gene: EZH2 / 2146
• HGNCID: 3527
• Length: 759
• Species: Homo sapiens
• Alignment Length: 889
• Identity: 182/889 - (20%)
• Similarity: 304/889 - (34%)
• Gaps: 287/889 - (32%)

  Fly   871 ISDTARSKIKGPVPIQESDSKSHTSGLNS----KRKGSASSFFSSSSSSTSSEAEYEAIDCVEKA 931
            :..|.:...|||| ......||....|..    :|.....|.|||:........|.
Human     9 MGQTGKKSEKGPV-CWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEI--------- 63

  Fly   932 RTSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTD 996
                           |||..   :.|.:.....:.:|.:| .|:.|.           ::.||.|
Human    64 ---------------LNQEW---KQRRIQPVHILTSVSSL-RGTREC-----------SVTSDLD 98

  Fly   997 EDNDRTLFPA----LKEKNISTILSDLEEISKDSCIGLDENGI--EPTILRKIPNTPKLNEECRR 1055
                   ||.    ||..|....:..:...|.     |.:|.:  :.|:|.   |.|.:.:|.
Human    99 -------FPTQVIPLKTLNAVASVPIMYSWSP-----LQQNFMVEDETVLH---NIPYMGDEV-- 146

  Fly  1056 SLTPVPPPGYNEEEIKKKVDCK----QKPSFEYDRIY----------------SDSEEEKEYQER 1100
                :...|...||:.|..|.|    ::..|..|.|:                .|.::.:|.:|:
Human   147 ----LDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEK 207

  Fly  1101 RKRNTEYMAQME----REF------------------LEEQEKRIEKSLDKNLQS--PNNIVKNN 1141
            :|...::....|    |:|                  .||.:::.::..::.|..  |.....|.
Human   208 QKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNI 272

  Fly  1142 NSPRNKNDETRKTAIS----QTRSCFESASKVDTTLVNIISVENDINEFGPHEEGDVLTNGCNKM 1202
            :.|..|:.:..::..|    ..|.||    |.|..|               |.:       ||..
Human   273 DGPNAKSVQREQSLHSFHTLFCRRCF----KYDCFL---------------HRK-------CNYS 311

  Fly  1203 Y--TNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLP-------------------PHSVS 1246
            :  |.:..|.|.|::.:.::....|..|..:.|.|...:|.                   |::.|
Human   312 FHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSS 376

  Fly  1247 LGDYPSGKVNETKNI-LKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKS---- 1306
            ....|:..|.|:|:. ..|||.        |.||.....|:    :::|:|.....|...|
Human   377 RPSTPTINVLESKDTDSDREAG--------TETGGENNDKE----EEEKKDETSSSSEANSRCQT 429

  Fly  1307 --KMTPNGD-----EWPDLAHKNVHFVPCDMY-------------KTRDQNEEMVILYTFLTKGI 1351
              ||.||.:     ||.. |..::..|....|             ||..|..|..:..:.:....
Human   430 PIKMKPNIEPPENVEWSG-AEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA 493

  Fly  1352 DAEDINFIKMSYLDHLHKEPYAMFLNNTHWVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCARTE 1416
            .|||::                                   .||.||:||      |:...|...
Human   494 PAEDVD-----------------------------------TPPRKKKRK------HRLWAAHCR 517

  Fly  1417 GFYKLDVRE--KAKHKYHYAKANTEDSFNEDR----SDEPTALTNHHHNKLI-------SKMQGI 1468
               |:.:::  .:.|.|:|...      :..|    |..|..:..:...|..       ::..|.
Human   518 ---KIQLKKDGSSNHVYNYQPC------DHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGC 573

  Fly  1469 SREARSNQRR---------------LLTAFGSMGESELLKFNQLKFR---KKQLKFAKSAIHDWG 1515
            ..:|:.|.::               |........:|:.:.......:   ||.|..|.|.:..||
Human   574 RCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWG 638

  Fly  1516 LFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFIN 1580
            :|..:|:..:|.:.||.|::|....||.|...|:.  ...|:||.::.:.::|||:.||..||.|
Human   639 IFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK--YMCSFLFNLNNDFVVDATRKGNKIRFAN 701

  Fly  1581 HSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLED 1624
            ||.||||||||:.:..:.:|.|::|:.|...||:.:||::...|
Human   702 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQAD 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	24/171 (14%)
		SET_SETD1	1490..1637	CDD:380946	48/138 (35%)
EZH2	XP_011514185.1	EZH2_WD-Binding	47..76	CDD:463308	9/55 (16%)
		PRC2_HTH_1	166..257	CDD:436286	12/90 (13%)
		preSET_CXC	572..603	CDD:408079	4/30 (13%)
		SET_EZH2	622..741	CDD:380995	47/120 (39%)