Protein Alignment Set1 and EZH1

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_001308008.1
• Gene: EZH1 / 2145
• HGNCID: 3526
• Length: 753
• Species: Homo sapiens
• Alignment Length: 841
• Identity: 179/841 - (21%)
• Similarity: 277/841 - (32%)
• Gaps: 279/841 - (33%)

  Fly   840 PTKRNFLERDLSDQEEMVQRSDSDKEDSNVEISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGS 904
            |.::||:..|.:....:....|..||:....|.:.          |...|.|.|  |......||
Human   122 PLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEEL----------INNYDGKVH--GEEEMIPGS 174

  Fly   905 ASSFFSSSSSSTSSEAEY-EAIDCVEKARTSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINV 968
            .          ..|:|.: |.:|.:.:....||:   |:..                 |.|
Human   175 V----------LISDAVFLELVDALNQYSDEEEE---GHND-----------------TSD---- 205

  Fly   969 RNLCSGSNEFKKEN--VTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILS---------DLEEI 1022
                 |..:..||:  ||::.|::.. :.::.:.:..||  .:...|.|.|         |::|.
Human   206 -----GKQDDSKEDLPVTRKRKRHAI-EGNKKSSKKQFP--NDMIFSAIASMFPENGVPDDMKER 262

  Fly  1023 SKDSCIGLDENGIEPTILRKI--PNTPKLNEE----------CRRSLTPVPPPGYNEEEIKKKVD 1075
            .::.....|.|.:.|.....|  ||...:..|          |||..               |.|
Human   263 YRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCF---------------KYD 312

  Fly  1076 CKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMERE------FLEEQEKRIEKSLDKNLQSP 1134
            |...|......:|            :::|.|  .::|.|      ||             .|:..
Human   313 CFLHPFHATPNVY------------KRKNKE--IKIEPEPCGTDCFL-------------LLEGA 350

  Fly  1135 NNIVKNNNSPRNK-NDETRKTAISQTRSCFE-SASKVDTTLVNIISVENDINEFGPHEEGDVLTN 1197
            ......:| ||:| :...|:.....:.||.. |||.|..|                 :|||...:
Human   351 KEYAMLHN-PRSKCSGRRRRRHHIVSASCSNASASAVAET-----------------KEGDSDRD 397

  Fly  1198 GCNKMYTNSKGKTKRTQSPVYSEGGSSQASQA-SQVALEHCYSLPP-------------HSVSLG 1248
            ..|...::|.....|.|:|.     ..:||.| .|:.:....|.|.             |.....
Human   398 TGNDWASSSSEANSRCQTPT-----KQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFN 457

  Fly  1249 DYPS-GKVNETKNILKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKSKMTPNG 1312
            ::.| .::..||..  ::....|:...:....|.....:|  .|||||         |.::
Human   458 NFCSIARLLGTKTC--KQVFQFAVKESLILKLPTDELMNP--SQKKKR---------KHRL---- 505

  Fly  1313 DEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKE-----PY 1372
              |  .||       |...:.:..|....: |.:               ...||..:.     |.
Human   506 --W--AAH-------CRKIQLKKDNSSTQV-YNY---------------QPCDHPDRPCDSTCPC 543

  Fly  1373 AMFLNNTHWVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKAN 1437
            .|..|.......|.       |..:.|...   .|.||.|...:....|.|||
Human   544 IMTQNFCEKFCQCN-------PDCQNRFPG---CRCKTQCNTKQCPCYLAVRE------------ 586

  Fly  1438 TEDSFNEDRSDEPTALT----NHHHNKLISKMQGISREARSNQRRLLTAFGSMGESELLKFNQLK 1498
                     .|....||    .|...|:      :|.:..|.||.|
Human   587 ---------CDPDLCLTCGASEHWDCKV------VSCKNCSIQRGL------------------- 617

  Fly  1499 FRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDM 1563
              ||.|..|.|.:..||.|..|.:..:|.:.||.|::|....||.|...|:.  ..||:||.::.
Human   618 --KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDK--YMSSFLFNLNN 678

  Fly  1564 ETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLED 1624
            :.::|||:.||..||.|||.||||||||:.:..:.:|.|::|:.|...||:.:||::...|
Human   679 DFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQAD 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	26/152 (17%)
		SET_SETD1	1490..1637	CDD:380946	49/135 (36%)
EZH1	NP_001308008.1	EZH2_WD-Binding	45..74	CDD:463308
		PRC2_HTH_1	165..268	CDD:436286	26/146 (18%)
		SANT	439..480	CDD:238096	5/42 (12%)
		preSET_CXC	566..597	CDD:408079	11/54 (20%)
		SET_EZH1	614..749	CDD:380994	52/149 (35%)