Protein Alignment Set1 and EHMT2

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: XP_006715037.2
• Gene: EHMT2 / 10919
• HGNCID: 14129
• Length: 1395
• Species: Homo sapiens
• Alignment Length: 1035
• Identity: 192/1035 - (18%)
• Similarity: 313/1035 - (30%)
• Gaps: 388/1035 - (37%)

  Fly   846 LERDLSDQEEMVQRSDSDKEDSNVEISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFS 910
            |...||::||..:..:.::|:...|                |.:.:...||..|.|.||:..
Human   472 LTEQLSEEEEEEEEEEEEEEEEEEE----------------EEEEEDEESGNQSDRSGSSGR--- 517

  Fly   911 SSSSSTSSEAEYEAIDCVEKARTS-EEDSPRGYGQRNLNQ----RTTTIRNRNLVGTMDVINVRN 970
                              .||:.. .:|||.....|...:    |....|..|.||:........
Human   518 ------------------RKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYME 564

  Fly   971 LCSGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISK---DSCIGLDE 1032
            :..||.|...|.........:.:||........|..|...:.......::.||:   ..|:..:.
Human   565 VPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATES 629

  Fly  1033 -----NGIEPTILRKIPNTP--------------------------------------------- 1047
                 :|....||::....|
Human   630 VDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVA 694

  Fly  1048 -KLNEECRRSL----------------------------------TPVPPPGYNEEEIKKKVDCK 1077
             :.::.|...|                                  .|.|||  ..:::..:.|..
Human   695 HRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPP--LSQDVPGRADTS 757

  Fly  1078 QKPSFEY---------------DRIYSDSEE-----------------------EK----EYQER 1100
            | ||...               |.|.|....                       ||    :..||
Human   758 Q-PSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESER 821

  Fly  1101 RKRNTEYMAQMEREFLEEQEKRIEK-------SLDKNLQSPNNIVKNNNSPRNKNDETRKTAISQ 1158
            ||:...:..|:   :|..::..::|       :||.|.||              :.::::|.:
Human   822 RKKLRFHPRQL---YLSVKQGELQKVILMLLDNLDPNFQS--------------DQQSKRTPL-- 867

  Fly  1159 TRSCFESASKVDTTLVNIISVENDINEFGPHEEGDVLTNGCNKMYTNSKGKTKRTQ--------- 1214
                ..:|.|....:.:::                 |..|.|   .|:..|.:||.
Human   868 ----HAAAQKGSVEICHVL-----------------LQAGAN---INAVDKQQRTPLMEAVVNNH 908

  Fly  1215 -----------SPVYS--EGGSSQASQASQVALEHCYS--LPPHSVSLGDYPSGKVNETKNILKR 1264
                       ..|||  |.||:....|:::......|  |....|.:....||  ..|..|...
Human   909 LEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG--GWTPIIWAA 971

  Fly  1265 EAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKSKMTPNGD---EWPDLAHK----- 1321
            |.::|.::..:...|......|                ||..::....:   .|......
Human   972 EHKHIEVIRMLLTRGADVTLTD----------------NVSERLVEEENICLHWASFTGSAAIAE 1020

  Fly  1322 ---NVHFVPCDMY------------KTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEP 1371
               |..   ||::            ..|:...:.|:|  ||::|.:.|..|           ||
Human  1021 VLLNAR---CDLHAVNYHGDTPLHIAARESYHDCVLL--FLSRGANPELRN-----------KE- 1068

  Fly  1372 YAMFLNNTHWVDHCTTDRA-FWPPPSKKRRKDDELIRHKTG--CARTEGFYKLDVR--------- 1424
                 .:|.|  ..|.:|: .|......|:     :|...|  ..|||.....||.
Human  1069 -----GDTAW--DLTPERSDVWFALQLNRK-----LRLGVGNRAIRTEKIICRDVARGYENVPIP 1121

  Fly  1425 -------EKAKHKYHYAKANTEDS-FNEDRSDEPTALTNHHH----------NKLISKMQGISRE 1471
                   |.....|.|...|.|.| .|.||:     :|:..|          |.|..::.  .|.
Human  1122 CVNGVDGEPCPEDYKYISENCETSTMNIDRN-----ITHLQHCTCVDDCSSSNCLCGQLS--IRC 1179

  Fly  1472 ARSNQRRLLTAFGSMGESELLKFNQ-------LKFR------KKQLKFAKSAIHDWGLFAMEPIA 1523
            ......|||..|..:....:.:.||       .|.|      |.:|:..::|...||:.|::.|.
Human  1180 WYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIP 1244

  Fly  1524 ADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMET----IIDATKCGNLARFINHSCN 1584
            ....:.||||::|....||:||        ..||||.:|.:.    .|||...||::|||||.|:
Human  1245 QGTFICEYVGELISDAEADVRE--------DDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCD 1301

  Fly  1585 PNCY-AKVITIESE---KKIVIYSKQPIGINEEITYDYK---FPLEDEKIPCLCGAQGCR 1637
            ||.. .:|..:..:   .:|..:|.:.|...||:.:||.   :.::.:...|.||::.|:
Human  1302 PNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK 1361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	35/173 (20%)
		SET_SETD1	1490..1637	CDD:380946	49/170 (29%)
EHMT2	XP_006715037.2	PHA03247	<126..382	CDD:223021
		2A1904	<396..504	CDD:273344	8/47 (17%)
		EHMT_ZBD	598..727	CDD:411018	11/128 (9%)
		ANKYR	806..1072	CDD:440430	58/348 (17%)
		ANK repeat	864..893	CDD:293786	7/54 (13%)
		ANK repeat	928..960	CDD:293786	6/31 (19%)
		ANK repeat	962..993	CDD:293786	6/32 (19%)
		ANK repeat	1002..1033	CDD:293786	4/33 (12%)
		ANK repeat	1035..1066	CDD:293786	7/32 (22%)
		SET_EHMT2	1133..1371	CDD:380931	67/244 (27%)