Protein Alignment Set1 and nsd3

DIOPT Version :10

• Sequence 1: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Sequence 2: NP_001362267.1
• Gene: nsd3 / 100216035
• XenbaseID: XB-GENE-5992933
• Length: 1451
• Species: Xenopus tropicalis
• Alignment Length: 1470
• Identity: 285/1470 - (19%)
• Similarity: 455/1470 - (30%)
• Gaps: 498/1470 - (33%)

  Fly   449 TAFQPDFHPVQPPPPPPEEI-----------------------DNWDEEEHDKNSIVPTHY---- 486
            :..||||   |.|.|..|::                       .|.....:...:.....|
 Frog    49 SGLQPDF---QYPTPTTEDLPPLTNGYQPSLGYEPQGKYYSQFPNGSANGYGTRNFTALEYYHLE 110

  Fly   487 --------GCMAKLQPPVPSNVNFATKLQ----SVTQPNSDPGTVDLDTRIALIFKGKTFGNAPP 539
                    | |:|..||.|::.  .|.||    |.|.|....|:.::..||.     ||..|...
 Frog   111 TAALRPVEG-MSKASPPQPTSP--PTLLQAPPLSTTTPQKKTGSPEIKLRIT-----KTIQNGRE 167

  Fly   540 FLQMDSSDSETDQGKPEVFSDVNSDSNNSENKKRSCEKNNKVLHQPNEASDISSDEELIGKKDK- 603
            ..:.........:     |..........|.:|...||..|..|..:........||:..::.:
 Frog   168 MFESSLCGDLLHE-----FHASEMTKKKHERRKERREKRKKSRHHHHHHHHHHHREEVKAEEQQP 227

  Fly   604 ---SKLSLICEKEVNDDNMSLSSLSSQ---------EDPIQTKEGA-EYKSIMSS---YMYSHSN 652
               .||....|:|....::.:|.||.:         .|.:.:|.|. .:...|.|   .::.||.
 Frog   228 PKMKKLEPPPEEERVQKHLPVSPLSPEVRTGVWFHVGDLVWSKVGTFPWWPCMVSCDPQLHVHSK 292

  Fly   653 QN---PFYYHASGYGHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNFDSFSKPYDYNKGALSD 714
            .|   ...||.    .:.|..|..         |:||.:.:|        .:.....|.:....|
 Frog   293 INTRGAREYHV----QFFSSEPER---------AWVHEKRMK--------EYRGEQQYEQLVAED 336

  Fly   715 ------QNDGI--------RQKVKQVIG----------------------YIVEELKQILKRDVN 743
                  |::.:        |::|:..||                      |:.||.....|:.||
 Frog   337 SAKACNQSEKLKMRKPRPQRERVQWEIGIAHAEKALRMTREERIEQYTFIYVDEEKPPEPKKPVN 401

  Fly   744 ----------------KRMIEI-----------TAFKHFETWWD---EHTSKARSKPLFEKADST 778
                            .|:.|:           :...|...  |   ||..:::.||..|:....
 Frog   402 IGKKSRRSTSSSEPESNRLSEVLPSPPRQPSAPSPISHNNK--DSPAEHRRQSQRKPPHEEEHPP 464

  Fly   779 VNTPLNCIKDTSYNEKNPDINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKR 843
            ...|......|:...|:...::|:  |:...|.|                    :.:.||:....
 Frog   465 QPPPAKTPWKTAAARKSLPASVLL--HKGTLDLQ--------------------KCNMSPVVKIE 507

  Fly   844 NFLERDLSDQEEMVQRSDSDKEDSN-VEISDTARSKIKGPVPIQESDSKS-------HTSGLNSK 900
            |.|....:..|...|...:.||..| .||:..|..:...|.|.|:|:..|       .|||..
 Frog   508 NVLALQNATSEGFEQFIYTTKEVGNKTEITVKAPERAFAPSPNQKSEKSSAQHTPAPETSGAT-- 570

  Fly   901 RKGSASSFFSSSSSSTSSEAEYEAIDCVEKARTSE---EDSPRGYGQRNLNQ-RTTTIRNRNLVG 961
              |.:.......|:.|.||:| :::|.:.|.:..:   ||.|....|..|.: .:.:...|.::.
 Frog   571 --GPSEKKHQRRSNRTRSESE-KSLDSMPKKKVKKEQVEDIPLTAVQTGLQKGASISAEPRKIIN 632

  Fly   962 TMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNIS------------- 1013
            ......:.:.|....:..:.:.......:.|.|..:.:.|    .|.:..||
 Frog   633 LNGASEISDACKPLKKRSRASTDVELANSSYRDASDSDSR----GLNDTQISFEKQTDSPSAAAD 693

  Fly  1014 TILSDLEEIS---------KDS--------------------------CIGLD------------ 1031
            ...||::.:.         :||                          |:|:|
 Frog   694 ADASDVQSVDSSVSHRSSRRDSVCQICESYGESLVSCDGECSRLFHLECLGMDTLPDGKFICMEC 758

  Fly  1032 ENGIEPTILRKIPNTPKLNEECRRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSE---- 1092
            :.|:......|||:|     ..:|...|.....|:|       .|.:    :|.....||:
 Frog   759 KTGLHTCFSCKIPST-----SVKRCSAPCCGKFYHE-------TCAR----QYSATIFDSKGFRC 807

  Fly  1093 ----------EEKEYQERRKRNTEYMAQMER---------EFLEEQEKRIEKSLDKNLQSPNNIV 1138
                      ::..|:..:.|    |....|         ..:......:..||         |:
 Frog   808 PHHCCSSCTADKDPYRACKGR----MLSCVRCPVAYHNGDSCIAAGSLHLSSSL---------II 859

  Fly  1139 KNNNSPRNKNDETRKTAISQTRSCFESASKV---DTTLVNIISVENDINEFGPHEEGDVLTNGCN 1200
            .:|:|.|:.:    .::......||..|..:   |.:||:.:|.::..          :||:
 Frog   860 CSNHSKRSGH----ASSSVNVGFCFVCARGLIVQDYSLVSSMSFKSHF----------LLTD--- 907

  Fly  1201 KMYTNSKGKTKRTQ----------SPVY----SEGGSSQASQASQVALEH--CYSL--PPHSVSL 1247
                     :||.:          ||.|    .:||.......|..|..|  |.:|  |..|.|.
 Frog   908 ---------SKRAELMKIPMIPSSSPAYIKKSEKGGGKLLCCDSCPAAFHPSCLNLEMPQGSWSC 963

  Fly  1248 GDYPSGKVNETKNILKREAENIAIVSQMTRTGPG---RPRKDPICIQKKKRDLAPRMSNVKSKMT 1309
            .|..|||....|.|:..:..|.       |..|.   .||..|:.||..|.|:
 Frog   964 NDCRSGKKLHYKQIVWVKLGNY-------RWWPAEICNPRSVPLNIQGLKHDI------------ 1009

  Fly  1310 PNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAM 1374
              ||                                                          :.:
 Frog  1010 --GD----------------------------------------------------------FPV 1014

  Fly  1375 FLNNTH---WVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKA 1436
            |...:|   ||..   .|.|......|...|.:...:||       |.|  ..|:|..::...||
 Frog  1015 FFFGSHDYYWVHQ---GRVFPYVEGDKSFADGQTSINKT-------FKK--ALEEAARRFQELKA 1067

  Fly  1437 NTEDSFN---EDRSDEPTALTNHHHNKLISKMQ----GISREARSNQR---------------RL 1479
            ..|....   |..|.:|....:...||.:.|:|    .:|...|.|.|               |:
 Frog  1068 QRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRM 1132

  Fly  1480 L-----TAFGSMGESELLKFNQLKFRKKQLKFAKSAIHD---WGLFAMEPIAADEMVIEYVGQMI 1536
            |     ......||..|   || .|.|:....|:..|.:   |||.....|...|.|.||||::|
 Frog  1133 LLYECHPQICPAGEHCL---NQ-NFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELI 1193

  Fly  1537 RPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIV 1601
            .......|..:....|..:.||..:..:.||||...||.:||:||||||||..:..|:..:.::.
 Frog  1194 DEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVG 1258

  Fly  1602 IYSKQPIGINEEITYDYKFP-LEDEKIPCLCGAQGCRGTL 1640
            :::...|....|:|::|... |.:.:..|.|||:.|.|.|
 Frog  1259 LFALCDIPKGAELTFNYNLDCLGNGRRECHCGAENCSGFL 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	33/173 (19%)
		SET_SETD1	1490..1637	CDD:380946	48/150 (32%)
nsd3	NP_001362267.1	PWWP_NSD3_rpt1	261..389	CDD:438991	24/148 (16%)
		PHD1_NSD3	717..759	CDD:277119	3/41 (7%)
		PHD_SF	764..810	CDD:473978	12/61 (20%)
		PHD_SF	811..863	CDD:473978	7/64 (11%)
		PHD_SF	934..966	CDD:473978	9/31 (29%)
		PWWP_NSD3_rpt2	973..1067	CDD:438994	28/184 (15%)
		AWS	1118..1156	CDD:465559	8/41 (20%)
		SET_NSD3	1158..1299	CDD:380989	46/141 (33%)
		PHD5_NSD3	1337..1379	CDD:277131
		C5HCH	1378..1427	CDD:465605