DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)80Fg and Dnajc16

DIOPT Version :9

Sequence 1:	NP_001015187.2	Gene:	l(3)80Fg / 3354941	FlyBaseID:	FBgn0287183	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001014216.1	Gene:	Dnajc16 / 362652	RGDID:	1359395	Length:	771	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	205/830 - (24%)
Similarity:	389/830 - (46%)	Gaps:	127/830 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISNYIITILVLCTTSYIHVCSSLN-DPYAILGINKKATTYEIREAYKELAKKWHPDKVKNDYGAE 69
            ||...:.:|||...|    .|:|: |||.:||:::.|:..:|::|||:||::|||||.|:....:
  Rat     8 ISWQFLIVLVLILQS----LSALDFDPYRVLGVSRTASQADIKKAYKKLAREWHPDKNKDPGAED 68

  Fly    70 KFIQIKLAYEILADLDRRRIFDRYGVSDINSQYFQKKHDYSEYNRFTLNQNDDDFGQRFDIKQDI 134
            |||||..|||||::.::|..:|.||.:..| |.:|::.:| .:..|..|...|:....|....:
  Rat    69 KFIQISKAYEILSNEEKRTNYDHYGDAGEN-QGYQQQREY-RFRHFHENFYFDESFFHFPFNSE- 130

  Fly   135 AFYQKLSITENY------FEKMILSKNAKKVHVVMFYNDWCFKCTRIVDAFKKILELLQPIGINF 193
               ::.||.|.|      :...::..:.||.:::...:||||.|..|...:|::::.|:.:|:..
  Rat   131 ---RRDSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPIWKEVVQELEGLGVGI 192

  Fly   194 ATVNAVHEESVFRKCGAREVPQLVLILDNQYFLYRDHSFTPQKVVEFIRKKIPFNVFKRIEHDNF 258
            ..|:|.:|..:....||...|.::.|::.:...:. ::...:.:.:|:...:|.|:.:::.:.|:
  Rat   193 GVVHAGYERRLAHHLGAHSTPSILGIINGKISFFH-NAVVHENLRQFVESLLPGNLVEKVTNKNY 256

  Fly   259 NDFLGGW-SDNRARALIFEPRSLTRLRYLLTAFEFYDRVAFGFVNTISKDSSNIITRFKVNTSLD 322
            ..||.|| .:|:..||:|.......|.|.||||.:.|.|:||:|....:....:..::.||....
  Rat   257 VRFLSGWQQENKPHALLFGQTPAAPLLYKLTAFAYKDYVSFGYVYVGLRGVEEMTRQYNVNIYAP 321

  Fly   323 TLILFNEDTTTFTASVCMEEIPNHILVNMVSTNQFLAFPRISSQNIMESVCPTEWNRQRKHLCVI 387
            |:::|.|.......::....:...::.:.::.|::|...|::||.:...:||.:.:.:::..||:
  Rat   322 TMLIFKEHINKPADAIQARGLKKQVIEDFITQNKYLLASRLTSQKLFHELCPVKRSHRQRKYCVV 386

  Fly   388 LIT--ENNRKKDFERVALRNIALSVGYNSEKVRFAYIFKESQPDFIKSI------SKGSFKDSLI 444
            |:|  .|...|.|:..    ::.::....:.|||.:::...|.:|..::      .:|....|::
  Rat   387 LLTAEANKLSKPFDAF----LSFALANTQDTVRFVHVYSSRQQEFASTLLPDIEAFQGKSGVSIL 447

  Fly   445 EIVIIWRRDK------KRIKYNWVYVAKQNGNSSPEHLMNSTKDQISNAVKKLLKNSEALCYEAI 503
            |     ||:.      |.::..|      .|:.|.:.::....||       |.|:...|..||:
  Rat   448 E-----RRNTAGRVVFKTLEDPW------TGSESDKFVLLGYLDQ-------LRKDPAFLSSEAV 494

  Fly   504 VENLFNEHSQGILTKWISQFLY-VVDYLSDNIED------EHLLAVFSLLGTIAFMFTVGYVLIY 561
            :.:|.:|.:...|.:|    || |.|||||..|.      ..::.:.||:.:..|:. .|.|::.
  Rat   495 LPDLTDELAPVFLLRW----LYSVSDYLSDFWESLLHSNWREMMPLLSLIFSALFIL-FGTVIVQ 554

  Fly   562 FVRVEEKYLKAHGHLIDIQDQRHI----------------NLIPE---LKLYELRAEKYNGMVRL 607
            ......:..::|.     .|:..:                :.||:   :::.||....|...:..
  Rat   555 AFSDSNEERESHP-----PDKEEVPEKAGKTEPSFTKESSSKIPKKGFVEVTELTDVTYTSNLVR 614

  Fly   608 LKPGCRTLLLINDCQSRHKLIPYFHKAVWPYRKSKTLLFGHMVIERGLPWFAEILRLSLSK---- 668
            |:||...::||....::..|:..|...|:.:..|.:|.|..:.:::...|...:|..:...
  Rat   615 LRPGHMNVVLILSNSTKTSLLQKFALEVYTFTGSSSLHFSFLTLDKHREWLEYLLEFAQDAAPIP 679

  Fly   669 ---NRHLQVNPRNCVGTVLALNGHRKYFCMYHAKHPESALGTKRTLKNTQKLLDANEDPEIGTFL 730
               ::|..  .|:..|.|||||||:||||::                   |.|...::..:|:.
  Rat   680 NQYDKHFM--ERDYTGYVLALNGHKKYFCLF-------------------KPLKTVDEETVGSC- 722

  Fly   731 KRDFSEESESEPNILLEDNLLNG----LDNWLERLFDGRTQKYYINYWPD 776
              |. :.|..:|...|....|.|    |..|:|||.:|..|::||..||:
  Rat   723 --DL-DSSRGKPPCGLGPKPLKGKLSKLSLWMERLLEGSLQRFYIPSWPE 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)80Fg	NP_001015187.2	DnaJ	30..>94	CDD:223560	30/63 (48%)
		DnaJ	30..91	CDD:278647	29/60 (48%)
		TRX_DnaJ	134..244	CDD:239261	23/115 (20%)
Dnajc16	NP_001014216.1	DnaJ	29..90	CDD:278647	29/60 (48%)
		TRX_DnaJ	133..242	CDD:239261	23/109 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..590		2/35 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350640
Domainoid	1	1.000	143	1.000	Domainoid score	I4558
eggNOG	1	0.900	-	-		E2759_KOG0715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45414
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3105
OMA	1	1.010	-	-		QHG46031
OrthoDB	1	1.010	-	-		D1253259at2759
OrthoFinder	1	1.000	-	-		FOG0007433
OrthoInspector	1	1.000	-	-		oto96270
orthoMCL	1	0.900	-	-		OOG6_106201
Panther	1	1.100	-	-	LDO	PTHR44303
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4807
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770