DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)80Fg and Dnajc10

DIOPT Version :9

Sequence 1:	NP_001015187.2	Gene:	l(3)80Fg / 3354941	FlyBaseID:	FBgn0287183	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001099956.2	Gene:	Dnajc10 / 295690	RGDID:	1307813	Length:	793	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	146/754 - (19%)
Similarity:	266/754 - (35%)	Gaps:	226/754 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CLISNYIITILVLCTTSYIHVCSSLNDPYAILGINKKATTYEIREAYKELAKKWHPDKVKNDYGA 68
            ||:..|::.::           .:..:.|::||::|.|::.|||:|:|:||.|.||||..|:..|
  Rat    20 CLLVLYVVIVV-----------GTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNA 73

  Fly    69 E-KFIQIKLAYEILADLDRRRIFDRYGVSDINSQYFQKKHDYSEYNRFTLNQNDDDFGQRFDIKQ 132
            . .|::|..|||:|.|.|.|:.:|:||...:......:...:| |.|:.....|||
  Rat    74 HGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWS-YYRYDFGIYDDD--------- 128

  Fly   133 DIAFYQKLSITENYFEKMILSKNAKKVHVVMFYNDWCFKCTRIVDAFKKILELLQPIGINFATVN 197
                .:.:::....|:..:   |:.::..|.||:..|..|..:...:::..:.:..: :....||
  Rat   129 ----PEIITLERREFDAAV---NSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGL-LRIGAVN 185

  Fly   198 AVHEESVFRKCGAREVPQLVLILDNQYFLYRDHSFTPQKVVEFIRKKIPFNVFKRIEHDNFNDFL 262
            ...:..:.|..|....|.|        |::|    :....|::             ..|...:.|
  Rat   186 CGDDRMLCRMKGVNSYPSL--------FIFR----SGMAAVKY-------------NGDRSKESL 225

  Fly   263 GGWSDNRARALIFEPRSLTRLRYLLTAFEFYDRVAFGFVNTI---SKDSSNIITRFKVNTSLDTL 324
            ..::....|..:.|..:...:..:.|||    ....|::.|.   .:|.....||.:::..||.|
  Rat   226 VSFAMQHVRTTVTELSTGNFVNAIETAF----AAGIGWLITFCFKGEDCLTPQTRLRLSGMLDGL 286

  Fly   325 ILFNEDTTTFTASVCMEEIPNHILVNMVSTNQFLAFPRISSQNIMESVCPTEWNRQRKHLCVILI 389
            :...........|:|..      |....||..:  ||..::.|          |:::.  .|:.:
  Rat   287 VNVGWVDCDTQDSLCKS------LDATASTTAY--FPPGATLN----------NKEKS--SVLFL 331

  Fly   390 TENNRKKDFERVALRNIALSVGYNSEKVRFAYIFKESQPDFIKSISKGSFKDSLIEIVIIWRRDK 454
            ...:.|:.:..: :.|:                     ||| :.:|....:|.|..
  Rat   332 NSLDAKEIYMEI-IHNL---------------------PDF-ELLSANKLEDRLAH--------- 364

  Fly   455 KRIKYNWV---YVAKQNGNSSPEHLMNSTKDQISNAVKKLLKNSEALCYEAIVENLFN-EHSQGI 515
                :.|:   :..|....:.||          ...:|.||||      |.|....|: ..:.||
  Rat   365 ----HRWLVFFHFGKNENANDPE----------LKKLKTLLKN------EHIQVGRFDCSSAPGI 409

  Fly   516 LTKWISQFLYVVDYLSDNIEDEHLLAVFSLLGTIAFMFTVGYVLIYFVRVEEKYLKAHGHLIDIQ 580
            .:.     |||.         :..||||...||..:....|..::|.:....|. ..:.|:..:.
  Rat   410 CSD-----LYVF---------QSCLAVFKGQGTKEYEIHHGKKILYDILAFAKE-SVNSHVTTLG 459

  Fly   581 DQRHINLIPELKLYELRAEKYNGMVRLLKPGCRTLLLINDCQSRHKLIPYFHKAVWPYRKSKTLL 645
            .|.    .|       .::|...:|....|.|      ..|::   |:|       ..||:.|||
  Rat   460 PQN----FP-------ASDKEPWLVDFFAPWC------PPCRA---LLP-------ELRKASTLL 497

  Fly   646 FGHM-------VIERGLPWFAEILRLSLSKNRHLQVNPRNCV---GTVLALNGHRKYFCMYHAKH 700
            :|.:       .|..|           |....::|..|...|   .:|....||.
  Rat   498 YGQLKVGTLDCTIHEG-----------LCNMYNIQAYPTTVVFNQSSVHEYEGHH---------- 541

  Fly   701 PESALGTKRTLKNTQKLLDANED---PEIGTFLKRDFSE 736
                        :.:::|:..||   |.:.:.....|:|
  Rat   542 ------------SAEQILEFIEDLRNPSVVSLTPTTFNE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)80Fg	NP_001015187.2	DnaJ	30..>94	CDD:223560	29/64 (45%)
		DnaJ	30..91	CDD:278647	28/61 (46%)
		TRX_DnaJ	134..244	CDD:239261	16/109 (15%)
Dnajc10	NP_001099956.2	DnaJ	34..>132	CDD:223560	37/111 (33%)
		DnaJ	35..97	CDD:278647	28/61 (46%)
		PDI_a_ERdj5_N	129..229	CDD:239301	18/128 (14%)
		ER_PDI_fam	130..551	CDD:273457	101/600 (17%)
		Trxb 1	235..350		25/160 (16%)
		Trxb 2	348..463		34/163 (21%)
		PDI_a_ERdj5_C	453..550	CDD:239302	26/156 (17%)
		PDI_a_ERdj5_C	556..663	CDD:239302	3/13 (23%)
		PDI_a_ERdj5_C	670..775	CDD:239302
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910