DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)80Fg and DNAJC2

DIOPT Version :9

Sequence 1:	NP_001015187.2	Gene:	l(3)80Fg / 3354941	FlyBaseID:	FBgn0287183	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_055192.1	Gene:	DNAJC2 / 27000	HGNCID:	13192	Length:	621	Species:	Homo sapiens

Alignment Length:	154	Identity:	45/154 - (29%)
Similarity:	67/154 - (43%)	Gaps:	38/154 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DPYAILG---INKKATTYEIREAYKELAKKWHPDKVK----------NDYGAEKFIQIKLAYEIL 81
            |.||:||   :..|||..:|:.|:|.:..|.||||.|          |||    |..|..|||:|
Human    88 DHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDY----FTCITKAYEML 148

  Fly    82 ADLDRRRIFDRYGVSDINS--QYFQKKHDYSEYNRFTLNQNDDDFGQRFDIKQDIAFYQKLSITE 144
            :|..:||.|:....:..||  ...:.|.::.|.......:|     .|:..|:::   .||....
Human   149 SDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFEVFTPVFERN-----SRWSNKKNV---PKLGDMN 205

  Fly   145 NYFEKMILSKNAKKVHVVMFYNDW 168
            :.||           .|.:||:.|
Human   206 SSFE-----------DVDIFYSFW 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)80Fg	NP_001015187.2	DnaJ	30..>94	CDD:223560	30/76 (39%)
		DnaJ	30..91	CDD:278647	29/73 (40%)
		TRX_DnaJ	134..244	CDD:239261	8/35 (23%)
DNAJC2	NP_055192.1	Epitope (recognized by CD8(+) cytotoxic T-lymphocytes)	23..31
		ZUO1	75..368	CDD:227594	45/154 (29%)
		DnaJ	88..158	CDD:278647	29/73 (40%)
		ZRF1-UBD	160..250		15/78 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315
		RAC_head	349..420	CDD:293322
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..453
		SANT	452..508	CDD:197842
		SANT	453..506	CDD:238096
		SANT	551..602	CDD:197842
		SANT	553..600	CDD:238096
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156718
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930