DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)80Fg and DNAJC16

DIOPT Version :9

Sequence 1:	NP_001015187.2	Gene:	l(3)80Fg / 3354941	FlyBaseID:	FBgn0287183	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_056106.1	Gene:	DNAJC16 / 23341	HGNCID:	29157	Length:	782	Species:	Homo sapiens

Alignment Length:	832	Identity:	203/832 - (24%)
Similarity:	395/832 - (47%)	Gaps:	120/832 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISNYIITILVLCTTSYIHVCSSLN-DPYAILGINKKATTYEIREAYKELAKKWHPDKVKNDYGAE 69
            ||...:.:|||    .:.:.|:|: |||.:||:::.|:..:|::|||:||::|||||.|:....:
Human     8 ISWQFLIVLVL----ILQILSALDFDPYRVLGVSRTASQADIKKAYKKLAREWHPDKNKDPGAED 68

  Fly    70 KFIQIKLAYEILADLDRRRIFDRYGVSDINSQYFQKKHDYSEYNRFTLNQN---DDDFGQ-RFDI 130
            |||||..|||||::.::|..:|:||.:..| |.:||:....||.....::|   |:.|.. .|:.
Human    69 KFIQISKAYEILSNEEKRSNYDQYGDAGEN-QGYQKQQQQREYRFRHFHENFYFDESFFHFPFNS 132

  Fly   131 KQDIAFYQKLSITENYFEKMILSKNAKKVHVVMFYNDWCFKCTRIVDAFKKILELLQPIGINFAT 195
            ::..:..:|..:..:::...::..:.||.:::...:||||.|..|...:|::::.|:.:|:....
Human   133 ERRDSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPVWKEVIQELEELGVGIGV 197

  Fly   196 VNAVHEESVFRKCGAREVPQLVLILDNQYFLYRDHSFTPQKVVEFIRKKIPFNVFKRIEHDNFND 260
            |:|.:|..:....||...|.::.|::.:...:. ::...:.:.:|:...:|.|:.:::.:.|:..
Human   198 VHAGYERRLAHHLGAHSTPSILGIINGKISFFH-NAVVRENLRQFVESLLPGNLVEKVTNKNYVR 261

  Fly   261 FLGGW-SDNRARALIFEPRSLTRLRYLLTAFEFYDRVAFGFVNTISKDSSNIITRFKVNTSLDTL 324
            ||.|| .:|:...|:|:...:..|.|.||||.:.|.::||:|....:.:..:..|:.:|....||
Human   262 FLSGWQQENKPHVLLFDQTPIVPLLYKLTAFAYKDYLSFGYVYVGLRGTEEMTRRYNINIYAPTL 326

  Fly   325 ILFNEDTTTFTASVCMEEIPNHILVNMVSTNQFLAFPRISSQNIMESVCPTEWNRQRKHLCVILI 389
            ::|.|........:....:...|:.:.::.|::|...|::||.:...:||.:.:.:::..||:|:
Human   327 LVFKEHINRPADVIQARGMKKQIIDDFITRNKYLLAARLTSQKLFHELCPVKRSHRQRKYCVVLL 391

  Fly   390 TENNRK--KDFERVALRNIALSVGYNSEKVRFAYIFKESQPDFIKSISKGS--FKDSLIEIVIIW 450
            |....|  |.||..    ::.::....:.|||.:::...|.:|..::...|  |:......::..
Human   392 TAETTKLSKPFEAF----LSFALANTQDTVRFVHVYSNRQQEFADTLLPDSEAFQGKSAVSILER 452

  Fly   451 RRDKKRIKYN-----WVYVAKQNGNSSPEHLMNSTKDQISNAVKKLLKNSEALCYEAIVENLFNE 510
            |....|:.|.     |:      |:.|.:.::....||       |.|:...|..||::.:|.:|
Human   453 RNTAGRVVYKTLEDPWI------GSESDKFILLGYLDQ-------LRKDPALLSSEAVLPDLTDE 504

  Fly   511 HSQGILTKWISQFLYVVDYLSDNIEDEHLLAVF-----SLLGTIAFMFTVGYVLIYFVRVEEKYL 570
            .:...|.:|   |....||:||..:     ::|     .::..::.:|:..::|...|.|:.
Human   505 LAPVFLLRW---FYSASDYISDCWD-----SIFHNNWREMMPLLSLIFSALFILFGTVIVQA--- 558

  Fly   571 KAHGHLIDIQDQR------------------------HINLIPE---LKLYELRAEKYNGMVRLL 608
                 ..|..|:|                        :.:.||:   :::.||....|...:..|
Human   559 -----FSDSNDERESSPPEKEEAQEKTGKTEPSFTKENSSKIPKKGFVEVTELTDVTYTSNLVRL 618

  Fly   609 KPGCRTLLLINDCQSRHKLIPYFHKAVWPYRKSKTLLFGHMVIERGLPWFAEILRLSLSK----- 668
            :||...::||....::..|:..|...|:.:..|..|.|..:.:::...|...:|..:...
Human   619 RPGHMNVVLILSNSTKTSLLQKFALEVYTFTGSSCLHFSFLSLDKHREWLEYLLEFAQDAAPIPN 683

  Fly   669 --NRHLQVNPRNCVGTVLALNGHRKYFCMYHAKHPESALGTKRTLKNTQKLLDANEDPEIGTFLK 731
              ::|..  .|:..|.|||||||:||||::                ..||.::  |:..||:...
Human   684 QYDKHFM--ERDYTGYVLALNGHKKYFCLF----------------KPQKTVE--EEEAIGSCSD 728

  Fly   732 RDFS---EESESEPNILLEDNLLNG----LDNWLERLFDGRTQKYYINYWPD 776
            .|.|   .||..:|:..|....:.|    |..|:|||.:|..|::||..||:
Human   729 VDSSLYLGESRGKPSCGLGSRPIKGKLSKLSLWMERLLEGSLQRFYIPSWPE 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)80Fg	NP_001015187.2	DnaJ	30..>94	CDD:223560	30/63 (48%)
		DnaJ	30..91	CDD:278647	29/60 (48%)
		TRX_DnaJ	134..244	CDD:239261	20/109 (18%)
DNAJC16	NP_056106.1	DnaJ	29..>142	CDD:333066	42/113 (37%)
		TRX_DnaJ	136..245	CDD:239261	20/109 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..593		2/30 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156722
Domainoid	1	1.000	151	1.000	Domainoid score	I4370
eggNOG	1	0.900	-	-		E2759_KOG0715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45414
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3049
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46031
OrthoDB	1	1.010	-	-		D1253259at2759
OrthoFinder	1	1.000	-	-		FOG0007433
OrthoInspector	1	1.000	-	-		oto89140
orthoMCL	1	0.900	-	-		OOG6_106201
Panther	1	1.100	-	-	LDO	PTHR44303
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8355
SonicParanoid	1	1.000	-	-		X4807
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800