DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)80Fg and dnj-8

DIOPT Version :9

Sequence 1:	NP_001015187.2	Gene:	l(3)80Fg / 3354941	FlyBaseID:	FBgn0287183	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001040753.1	Gene:	dnj-8 / 174093	WormBaseID:	WBGene00001026	Length:	813	Species:	Caenorhabditis elegans

Alignment Length:	848	Identity:	233/848 - (27%)
Similarity:	417/848 - (49%)	Gaps:	123/848 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILVLCTTSYIHVCSSLN---DPYAILGINKKATTYEIREAYKELAKKWHPDKVKNDYGAEKFIQI 74
            :|:...:.::.|.|:|:   |||.:|||:::|:..||:.|||.||::|||||.|::..:.:|::|
Worm     2 LLLRIGSLFLLVSSALSQKEDPYKVLGISRRASAKEIKSAYKSLAREWHPDKRKDEAASGRFMEI 66

  Fly    75 KLAYEILADLDRRRIFDRYGVSDINSQY---FQKKHDYSEYNRFTLNQNDDDFGQRFDIKQDIAF 136
            ..|||:|:|..|:..:||:|..|...|:   .::...:..:..|      ..||  ||   :..|
Worm    67 AEAYEVLSDPLRKERYDRFGTFDDVKQFEDNAERARSFYGFGGF------GGFG--FD---ESVF 120

  Fly   137 YQKLSITENYFEKMILSKNAKKVHVVMFYNDWCFKCTRIVDAFKKILELLQPIGINFATVNAVHE 201
            ..|..::...::..||.::..|.::|..|:::|..|.|....:|:::..|:|:|...||||...|
Worm   121 EYKYRMSYQQYQFKILEESNTKPYIVYIYSNYCQMCYRFHPQWKRVIADLEPLGYGIATVNGNRE 185

  Fly   202 ESVFRKCGAREVPQLVLILDNQYFLYR-DHSFTPQKVVEFIRKKIPFNVFKRIEHD-NFNDFLGG 264
            :::..|.....||.||.|::.:....| |.||:.:.:|.|.:|.||.....:|... ..:.|:..
Worm   186 QNLMEKMRISHVPALVAIVEGRIIPMRIDSSFSDRSIVAFAQKVIPSYFMTKINSGVMLSRFVDQ 250

  Fly   265 W-SDNRARALIFEPRSLTRLRYLLTAFEFYDRVAFGFVNTISKDSSNIITRFKVNTSL-----DT 323
            | |.|:...:||...:..|:||||.|.::.....|.:|:.  .|||:.:...:.:..:     :.
Worm   251 WKSSNKISVVIFGAAANPRIRYLLAAMKYSQFARFAYVSL--SDSSDEVRILRESVDIKCVQCEN 313

  Fly   324 LILF----NEDTTTFTASVCMEEIPNHILVNMVSTNQFLAFPRISSQNIMESVCPTEWNRQRKHL 384
            ::::    :||.....:....:::....:...:..|:.|..||:|||.:::.|||.. :|..:||
Worm   314 ILIYGDMEHEDAVDRLSISEAKKLTMEAIDEFIERNKVLTLPRLSSQELLDEVCPVS-SRSPRHL 377

  Fly   385 CVIL-ITENNRKKD----FERVALRNIALSVGYNSEKVRFAYIFKESQPDFIKSIS---KGSFKD 441
            |||| :|.::.:::    |.|......::   :.|:||.|:||:.:.|.|::|..:   ||..|:
Worm   378 CVILPVTSHSSEEEHVDAFRRYVKDTKSI---WKSKKVNFSYIYVDKQKDWVKPFAEKRKGELKN 439

  Fly   442 SLIEIVIIWRRDKKRIKYNWVYVAKQNGNSSPEHLMNSTKDQISNAVKKLLKNSEALCYEAIVEN 506
            ...:::|.||.:.|:.::.|:..| ..|:       ..|.|.|.|.|:: .|..:..|   .|.|
Worm   440 EGRDLLIFWRTEYKKARFTWLEGA-WTGH-------KETDDLIMNVVEQ-RKRLDETC---TVGN 492

  Fly   507 LFNEHSQGILTKWISQFLYVVDYLSDNIEDEHLLAVFSLLGTIAFMFTVGYVLIYFVRVEEKYLK 571
            :.:|:...|.|:....|..:.:.:...:.:|......|.:||:..:.:||::..||........|
Worm   493 INDEYGLSIFTRCSRAFWRMWEVVWFRVSNEETYMFLSAVGTLFMIMSVGWLFSYFSEKPSDIKK 557

  Fly   572 AHGHLIDIQDQRHINLI--------PELK------------------------LYELRAEKYNGM 604
            ......|:.|......|        |..|                        ::|||||.|.||
Worm   558 RKPKANDVADLTGDPTIASDWHPDDPNTKKKDGDNSKQISSGKSKWAVAMKPLIHELRAETYFGM 622

  Fly   605 VRLLKPGCRTLLLINDCQSRHKLIPYFHKAVWPYRKSKTLLFGHMVIERGLPWFAEILR------ 663
            :||||||||:::|:.|.:::..||..|.:.|:|.|.:||..||.:::.:.|.||.::|.
Worm   623 IRLLKPGCRSMILLVDEENKDSLINKFSQYVYPLRNNKTFSFGFLIVPKNLDWFRKLLEHTLPTD 687

  Fly   664 --------LSLSKNRHLQ-VNPRNCVGTVLALNGHRKYFCMYHAKHPESALGTKRTLKNTQKLLD 719
                    :|.|..:.|: :|.|:.:||||.|.|.:.||.:||.||.|         .:.:..:|
Worm   688 GKPTPEPDVSQSMYKRLKLINHRHTIGTVLTLCGWKLYFSIYHPKHVE---------LSRRNFID 743

  Fly   720 ANEDP-----------EIGTFLKRDFSEESESEPNILLEDNLLNGLDNWLERLFDGRTQKYYINY 773
            .:|:|           |..:..::.....|.|:..:.:| |:|:|..||::||.:|..::|||..
Worm   744 TDEEPSSDDEASYRSDEFASMGEKKKLHRSSSQRGVNME-NVLDGFPNWMDRLLEGSIRRYYIPE 807

  Fly   774 WPD 776
            |||
Worm   808 WPD 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)80Fg	NP_001015187.2	DnaJ	30..>94	CDD:223560	30/63 (48%)
		DnaJ	30..91	CDD:278647	28/60 (47%)
		TRX_DnaJ	134..244	CDD:239261	31/110 (28%)
dnj-8	NP_001040753.1	DnaJ_bact	22..>86	CDD:274090	30/63 (48%)
dnj-8	NP_001040753.1	TRX_DnaJ	118..229	CDD:239261	31/110 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163478
Domainoid	1	1.000	205	1.000	Domainoid score	I1712
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45414
Inparanoid	1	1.050	321	1.000	Inparanoid score	I1492
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46031
OrthoDB	1	1.010	-	-		D1253259at2759
OrthoFinder	1	1.000	-	-		FOG0007433
OrthoInspector	1	1.000	-	-		oto19920
orthoMCL	1	0.900	-	-		OOG6_106201
Panther	1	1.100	-	-	LDO	PTHR44303
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8355
SonicParanoid	1	1.000	-	-		X4807
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940