DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)80Fg and DNAJA2

DIOPT Version :9

Sequence 1:	NP_001015187.2	Gene:	l(3)80Fg / 3354941	FlyBaseID:	FBgn0287183	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_005871.1	Gene:	DNAJA2 / 10294	HGNCID:	14884	Length:	412	Species:	Homo sapiens

Alignment Length:	280	Identity:	68/280 - (24%)
Similarity:	116/280 - (41%)	Gaps:	78/280 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YAILGINKKATTYEIREAYKELAKKWHPDKVKNDYGAEKFIQIKLAYEILADLDRRRIFDRY--- 93
            |.|||:...|:..|:::||::|||::|||  ||....:||.:|..|||:|::.::|.::|||
Human    10 YDILGVPPGASENELKKAYRKLAKEYHPD--KNPNAGDKFKEISFAYEVLSNPEKRELYDRYGEQ 72

  Fly    94 ----------GVSDINSQYFQKKHDYSEYNRFTLNQNDDDFGQRFDIKQDIAFYQKLSITENYFE 148
                      |:.||.|..|.     .....|..||:....|:|..  :|:....|:|:.:.|
Human    73 GLREGSGGGGGMDDIFSHIFG-----GGLFGFMGNQSRSRNGRRRG--EDMMHPLKVSLEDLY-- 128

  Fly   149 KMILSKNAKKVHVVMFYNDWCFKCT--------------------RIVDAFKKILELLQPIGINF 193
                  |.|...:.:..|..|..|:                    ||:     |.:|...:....
Human   129 ------NGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSACRGRGVRIM-----IRQLAPGMVQQM 182

  Fly   194 ATV--------NAVHEESVFRKCGAREVPQLVLILDNQYFLYRDH----SFT----------PQK 236
            .:|        ..::|:...:||..::|.:.|.||:........|    :||          |..
Human   183 QSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILEVHVDKGMKHGQRITFTGEADQAPGVEPGD 247

  Fly   237 VVEFIRKKIPFNVFKRIEHD 256
            :|..:::| ...||:|..:|
Human   248 IVLLLQEK-EHEVFQRDGND 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)80Fg	NP_001015187.2	DnaJ	30..>94	CDD:223560	27/74 (36%)
		DnaJ	30..91	CDD:278647	24/58 (41%)
		TRX_DnaJ	134..244	CDD:239261	25/151 (17%)
DNAJA2	NP_005871.1	PTZ00037	4..412	CDD:240236	68/280 (24%)
		CXXCXGXG motif	143..150		2/6 (33%)
		CXXCXGXG motif	159..166		0/6 (0%)
		CXXCXGXG motif	186..193		0/6 (0%)
		CXXCXGXG motif	202..209		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910