Protein Alignment Gfat1 and GFPT2

DIOPT Version :10

• Sequence 1: NP_001015157.2
• Gene: Gfat1 / 3354921
• FlyBaseID: FBgn0287209
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_005101.1
• Gene: GFPT2 / 9945
• HGNCID: 4242
• Length: 682
• Species: Homo sapiens
• Alignment Length: 700
• Identity: 444/700 - (63%)
• Similarity: 561/700 - (80%)
• Gaps: 24/700 - (3%)

  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLVTGLKRLEYRGYDSTGVAIDSPDN----KNIVMVKRTGKVKV 61
            |||||||:||..|::|:|:.:.|:.||:|||||||||.|||||..::    ::|.:||:.||||.
Human     1 MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKRGKVKA 65

  Fly    62 LEEAIQEHFSGREYSEPVLTHVGIAHTRWATHGVPCEKNSHPHRSDDENGFVVVHNGIITNYNDV 126
            |:|.:.:..| .:......||.|||||||||||||...||||.|||..|.|||:||||||||.|:
Human    66 LDEELYKQDS-MDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHNGIITNYKDL 129

  Fly   127 KTFLSKRGYEFESDTDTEVFAKLVHHLWKTHPT--YSFRELVEQAILQVEGAFAIAVKSKYFPGE 189
            :.||..:||||||:||||..|||:.:::....|  .:|..|||:.|.|:|||||:..||.::|||
Human   130 RKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSVHYPGE 194

  Fly   190 CVASRRSSPLLVGIKTKTRLATDHIPILYGKDDKKLCTDQDADSGKPQDIRPHGQSRELPVLPRS 254
            .||:||.||||:|:::|.:|:|:.|||||     :.||        .::::...::|    :.|.
Human   195 AVATRRGSPLLIGVRSKYKLSTEQIPILY-----RTCT--------LENVKNICKTR----MKRL 242

  Fly   255 ESTSEFMPLEEKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVRDGTLSIHRLKKSLDDPHAREI 319
            :|::....:.:|.||:||||||||:||||||||:|||||:|||.||.|||||:|:|..|..:|.|
Human   243 DSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSASDDPSRAI 307

  Fly   320 TTLKMEIQQIMKGNYDYFMQKEIFEQPDSVVNTMRGRVRFDGNAIVLGGIKDYIPEIKRCRRLML 384
            .||:||:|||||||:..||||||||||:||.|||||||.|:.|.::|||:||::.||:|||||::
Human   308 QTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIV 372

  Fly   385 IGCGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYC 449
            ||||||||:||||||:|||||||||||||||||||||||:|||||||||||||||||||:|||||
Human   373 IGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYC 437

  Fly   450 KQRGALIVGITNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQ 514
            |.||||.||:||||||||.||:.|||||||||||||||||||||||||||||.|:|||||:|||.
Human   438 KDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQN 502

  Fly   515 RRLEILQALSKLADQIRDVLQLDSKVKELAKDLYQHKSLLIMGRGYNFATCLEGALKVKELTYMH 579
            ||.||::.|..|.:.|::||.|:.|:.:||.:||..:|||:||||||:|||||||||:||:||||
Human   503 RRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMH 567

  Fly   580 SEGIMAGELKHGPLALVDDSMPVLMIVLRDPVYVKCMNALQQVTSRKGCPIIICEEGDEETKAFS 644
            ||||:|||||||||||:|..|||:|::::||.:.||.|||||||:|:|.|||:|.:.|.|:..|:
Human   568 SEGILAGELKHGPLALIDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFA 632

  Fly   645 SRHLEIPRTVDCLQGILTVIPMQLLSYHIAVLRGCDVDCPRNLAKSVTVE 694
            .:.:|:|.|||||||||:|||:||||:|:|||||.|||.|||||||||||
Human   633 YKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfat1	NP_001015157.2	PLN02981	1..694	CDD:215531	442/698 (63%)
GFPT2	NP_005101.1	PLN02981	1..682	CDD:215531	442/698 (63%)