Protein Alignment Dbp80 and EIF4A3

DIOPT Version :10

• Sequence 1: NP_001263168.1
• Gene: Dbp80 / 3354919
• FlyBaseID: FBgn0024804
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_055555.1
• Gene: EIF4A3 / 9775
• HGNCID: 18683
• Length: 411
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 137/404 - (33%)
• Similarity: 237/404 - (58%)
• Gaps: 26/404 - (6%)

  Fly    54 TKLSLDIQQKNPNSPLHSVKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQ 118
            ||:..:..::...:|     ||:.:.|:..||:||||.||..||.||:.|:..::..  :::|||
Human    24 TKVEFETSEEVDVTP-----TFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKG--RDVIAQ 81

  Fly   119 SQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCREIKLRFAVRGEE 183
            |||||||||.|.:::|..:::.:...|.|.|:||.|||:|..:....:|.: ..::....:.|..
Human    82 SQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDY-MNVQCHACIGGTN 145

  Fly   184 VDRS-KKIE--EHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIATQGHHDQCIRIHKML 245
            |... :|::  :|::.||||::.|. |:.|....:.|.:.||||||.|: .:|..:|...:::.|
Human   146 VGEDIRKLDYGQHVVAGTPGRVFDM-IRRRSLRTRAIKMLVLDEADEML-NKGFKEQIYDVYRYL 208

  Fly   246 NPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEGKYNAIQNIYG 310
            .|..|::..|||...|:::.....:.||..|.:.|:|.:||.|||::|..:.||.|::.:.::|.
Human   209 PPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYD 273

  Fly   311 CISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILS 375
            .:::.||:|||:|||...||..||.....:|:.:.||:...:|..::..||||..:|||:|::.:
Human   274 TLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWA 338

  Fly   376 RGIDIEQVTIVVNFDLPVDLDGMADCETYLHRIGRTGRFEPSALTRNSPIFGVKAESGKIGKEIN 440
            ||:|:.||::::|:|||      .:.|.|:|||||:||:....:..|.    ||.:..:|.::|.
Human   339 RGLDVPQVSLIINYDLP------NNRELYIHRIGRSGRYGRKGVAINF----VKNDDIRILRDIE 393

  Fly   441 RSSSGAESGSREMP 454
            :..|   :...|||
Human   394 QYYS---TQIDEMP 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp80	NP_001263168.1	DEADc_DDX19_DDX25	80..277	CDD:350721	68/199 (34%)
		SF2_C_DEAD	288..414	CDD:350174	49/125 (39%)
EIF4A3	NP_055555.1	DEAD-like_helicase_N	35..411	CDD:475120	135/393 (34%)
		Q motif	38..66		15/32 (47%)
		DEAD box. /evidence=ECO:0000305	187..190		2/2 (100%)