DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp80 and ddx19a

DIOPT Version :9

Sequence 1:	NP_001263168.1	Gene:	Dbp80 / 3354919	FlyBaseID:	FBgn0024804	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_001122187.1	Gene:	ddx19a / 563448	ZFINID:	ZDB-GENE-080721-12	Length:	471	Species:	Danio rerio

Alignment Length:	487	Identity:	260/487 - (53%)
Similarity:	331/487 - (67%)	Gaps:	31/487 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WAKKAEDQE-VSKLVDKL--------NLDSKSGEETDFDVADPAETSLLIKILGKGLVNTKLSLD 59
            ||...::|| .:|.|..|        :|...:|::.:.:..|.|..|||.|::...|||....::
Zfish     6 WALAVDEQESTTKPVGNLRIMEAENASLHQNNGDDEEDEKEDRATQSLLNKLIRSNLVNNTNQVE 70

  Fly    60 IQQKNPNSPLHSVKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQSQSGTG 124
            :.|::|||||:||||||.|.||..||||:|.||||.||||||.|||.:||:||||:|||||||||
Zfish    71 VLQRDPNSPLYSVKTFEELRLKPQLLKGVYEMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTG 135

  Fly   125 KTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCREIKLRFAVRGEEVDRSKK 189
            |||||||||||.|:......|.||:|||||||:|||:|..:||:|..|:.|.:||||..::|..:
Zfish   136 KTAAFVLAMLSHVDPACKWSQCLCISPTYELALQTGKVIEQMGKFYPEVTLAYAVRGHRMERGVR 200

  Fly   190 IEEHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIATQGHHDQCIRIHKMLNPHCQMLFF 254
            |::.|:|||||.:|||.||.:|.|.|||.||||||||||||||||.||.|||.:||...||||.|
Zfish   201 IKDQIVIGTPGTVLDWCIKLKLIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPKGCQMLLF 265

  Fly   255 SATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEGKYNAIQNIYGCISVGQAII 319
            |||:...|..||..:|.||.||:|.||||:|:.||||||.|.::|.|:||:.||||.|::.||:|
Zfish   266 SATFEDSVWKFAERVVPDPNIIKLKREEETLDTIKQYYVLCNSKEDKFNALCNIYGAITIAQAMI 330

  Fly   320 FCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVT 384
            ||||::.|.|||.:|:.:||.||:|:|::.|.||..|::|||.|.||||||||:.:||||:|||:
Zfish   331 FCHTRKMANWLAGQMSKEGHQVALLSGEMVVEQRAAVIERFRDGKEKVLITTNVCARGIDVEQVS 395

  Fly   385 IVVNFDLPVDLDGMADCETYLHRIGRTGRFEPSALTRNSPIFGVKAESGKIGKEINRSSSGAESG 449
            :|:|||||:|.|...|.|||||||||||||                  ||.|..||...|   ..
Zfish   396 VVINFDLPLDKDSNPDNETYLHRIGRTGRF------------------GKRGLAINMVDS---QR 439

  Fly   450 SREMPKEKENISLLKFFSL-TGNLDEAWDVQS 480
            |.|:.|..|.....|...| |.:|||...:.|
Zfish   440 SMEILKTYERHFDKKIARLDTDDLDEIEKIAS 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp80	NP_001263168.1	DEADc	75..277	CDD:238167	129/201 (64%)
		DEXDc	88..291	CDD:214692	129/202 (64%)
		Helicase_C	299..414	CDD:278689	70/114 (61%)
ddx19a	NP_001122187.1	PTZ00424	83..461	CDD:185609	230/398 (58%)
		P-loop_NTPase	86..288	CDD:304359	129/201 (64%)
		HELICc	299..434	CDD:238034	83/152 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2698
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	526	1.000	Inparanoid score	I1199
OMA	1	1.010	-	-		QHG55249
OrthoDB	1	1.010	-	-		D254883at33208
OrthoFinder	1	1.000	-	-		FOG0001995
OrthoInspector	1	1.000	-	-		otm25223
orthoMCL	1	0.900	-	-		OOG6_101341
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2081
SonicParanoid	1	1.000	-	-		X1312
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010