DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp80 and DDX25

DIOPT Version :9

Sequence 1:	NP_001263168.1	Gene:	Dbp80 / 3354919	FlyBaseID:	FBgn0024804	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	XP_011541092.1	Gene:	DDX25 / 29118	HGNCID:	18698	Length:	486	Species:	Homo sapiens

Alignment Length:	405	Identity:	236/405 - (58%)
Similarity:	294/405 - (72%)	Gaps:	3/405 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NLD---SKSGEETDFDVADPAETSLLIKILGKGLVNTKLSLDIQQKNPNSPLHSVKTFEALHLKA 82
            |:|   :...|:.:.||.|.|..|||.|::.:.||.:...:::.||:|:|||:||||||.|.||.
Human    45 NIDGSINNINEDDEEDVVDLAANSLLNKLIHQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKE 109

  Fly    83 SLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVL 147
            .|||||||||||.||||||.|||.:||.||||:|||||||||||||||||||||||.....||.|
Human   110 ELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCL 174

  Fly   148 CLSPTYELAIQTGEVAARMGQFCREIKLRFAVRGEEVDRSKKIEEHILIGTPGKLLDWGIKFRLF 212
            ||:||||||:|||.|..:||:||.::::.:|:||..:.|...|.:.|:|||||.:|||..|.:|.
Human   175 CLAPTYELALQTGRVVEQMGKFCVDVQVMYAIRGNRIPRGTDITKQIIIGTPGTVLDWCFKLKLI 239

  Fly   213 DMKKISVFVLDEADVMIATQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
            |:.||.|||||||||||.|||..|..|||.:.|...||||.||||:...|..||..|:.||.:|:
Human   240 DLTKIRVFVLDEADVMIDTQGFSDHSIRIQRALPSECQMLLFSATFEDSVWHFAERIIPDPNVIK 304

  Fly   278 LMREEESLENIKQYYVKCKNEEGKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVA 342
            |.:||.:|.||:||||.|::.:.||.|:.||||.|::|||||||.|:|.|.||..:|..|||.|:
Human   305 LRKEELTLNNIRQYYVLCEHRKDKYQALCNIYGSITIGQAIIFCQTRRNAKWLTVEMIQDGHQVS 369

  Fly   343 VLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLDGMADCETYLHR 407
            :|:|:|||.||..::.|||.|.||||||||:.:||||::||||||||||||......|.||||||
Human   370 LLSGELTVEQRASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVKQGEEPDYETYLHR 434

  Fly   408 IGRTGRFEPSALTRN 422
            |||||||....|..|
Human   435 IGRTGRFGKKGLAFN 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp80	NP_001263168.1	DEADc	75..277	CDD:238167	125/201 (62%)
		DEXDc	88..291	CDD:214692	123/202 (61%)
		Helicase_C	299..414	CDD:278689	72/114 (63%)
DDX25	XP_011541092.1	P-loop_NTPase	114..304	CDD:304359	117/189 (62%)
		DEXDc	115..318	CDD:214692	123/202 (61%)
		HELICc	314..450	CDD:238034	83/136 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2626
eggNOG	1	0.900	-	-		E1_KOG0332
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1220
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55249
OrthoDB	1	1.010	-	-		D254883at33208
OrthoFinder	1	1.000	-	-		FOG0001995
OrthoInspector	1	1.000	-	-		otm41569
orthoMCL	1	0.900	-	-		OOG6_101341
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840