Protein Alignment Dbp80 and DDX6

DIOPT Version :10

• Sequence 1: NP_001263168.1
• Gene: Dbp80 / 3354919
• FlyBaseID: FBgn0024804
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_004388.2
• Gene: DDX6 / 1656
• HGNCID: 2747
• Length: 483
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 132/425 - (31%)
• Similarity: 226/425 - (53%)
• Gaps: 37/425 - (8%)

  Fly    55 KLSLDIQQKN---PNSPLHSVK--TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADPPQN 114
            |.:|.:..|:   ..|.:.|.|  .||...||..||.||:.||:..||.|||.::|..|:.  ::
Human    73 KKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSG--RD 135

  Fly   115 MIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCREIKLRFAV 179
            ::|::::||||:.|:::.:|.|:::..::.|.:.:.||.|||:|..::..::.:.....|:....
Human   136 ILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATT 200

  Fly   180 RGEEV-DRSKKIEE--HILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIA---TQGHHDQC 238
            .|..: |...::::  |::|.|||::||. ||..:..:..:.:.||||||.:::   .|...|..
Human   201 GGTNLRDDIMRLDDTVHVVIATPGRILDL-IKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDII 264

  Fly   239 IRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEGKYN 303
            :.:.|    :.|:|.:|||:...|..|....:..|..|.|| ||.:|:.:.|||... .|..|.:
Human   265 LTLPK----NRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EELTLKGVTQYYAYV-TERQKVH 323

  Fly   304 AIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVL 368
            .:..::..:.:.|:||||::.:....||.|::..|:|...:...:....|..|...||:||.:.|
Human   324 CLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNL 388

  Fly   369 ITTNILSRGIDIEQVTIVVNFDLPVDLDGMADCETYLHRIGRTGRFEPSALTRN----SPIFGVK 429
            :.|::.:|||||:.|.:|:|||.|      ...|||||||||:|||....|..|    ...|.:|
Human   389 VCTDLFTRGIDIQAVNVVINFDFP------KLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLK 447

  Fly   430 AESGKIGKE-------INRSSSGAESGSREMPKEK 457
            :...::|.|       |::|...||..|..:..||
Human   448 SIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEK 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp80	NP_001263168.1	DEADc_DDX19_DDX25	80..277	CDD:350721	59/202 (29%)
		SF2_C_DEAD	288..414	CDD:350174	44/125 (35%)
DDX6	NP_004388.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		Q motif	96..124		13/27 (48%)
		SrmB	98..461	CDD:440279	119/377 (32%)
		DEAD box	246..249		2/2 (100%)
		Gyf binding. /evidence=ECO:0000269|PubMed:31439631	286..316		11/30 (37%)
		RecA-like domain 2. /evidence=ECO:0000269|PubMed:31439631	307..483		59/183 (32%)