Protein Alignment Dbp80 and Ddx6

DIOPT Version :10

• Sequence 1: NP_001263168.1
• Gene: Dbp80 / 3354919
• FlyBaseID: FBgn0024804
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_031867.1
• Gene: Ddx6 / 13209
• MGIID: 104976
• Length: 483
• Species: Mus musculus
• Alignment Length: 425
• Identity: 132/425 - (31%)
• Similarity: 225/425 - (52%)
• Gaps: 37/425 - (8%)

  Fly    55 KLSLDIQQKN---PNSPLHSVK--TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADPPQN 114
            |.:|.:..|:   ..|.:.|.|  .||...||..||.||:.||:..||.|||.::|..|:.  ::
Mouse    73 KKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSG--RD 135

  Fly   115 MIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCREIKLRFAV 179
            ::|::::||||:.|:::.:|.|:::..::.|.:.:.||.|||:|..::..::.:.....|:....
Mouse   136 ILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATT 200

  Fly   180 RGEEV-DRSKKIEE--HILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIA---TQGHHDQC 238
            .|..: |...::::  |::|.|||::||. ||..:..:..:.:.||||||.:::   .|...|..
Mouse   201 GGTNLRDDIMRLDDTVHVVIATPGRILDL-IKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDII 264

  Fly   239 IRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEGKYN 303
            :.:.|    :.|:|.:|||:...|..|....:..|..|.|| ||.:|:.:.|||... .|..|.:
Mouse   265 LTLPK----NRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EELTLKGVTQYYAYV-TERQKVH 323

  Fly   304 AIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVL 368
            .:..::..:.:.|:||||::.:....||.|::..|:|...:...:....|..|...||:||.:.|
Mouse   324 CLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNL 388

  Fly   369 ITTNILSRGIDIEQVTIVVNFDLPVDLDGMADCETYLHRIGRTGRFEPSALTRN----SPIFGVK 429
            :.|::.:|||||:.|.:|:|||.|      ...|||||||||:|||....|..|    ...|.:|
Mouse   389 VCTDLFTRGIDIQAVNVVINFDFP------KLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLK 447

  Fly   430 AESGKIGKE-------INRSSSGAESGSREMPKEK 457
            :...::|.|       |::|...||..|.....||
Mouse   448 SIEEQLGTEIKPIPSNIDKSLYVAEYHSEPAEDEK 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp80	NP_001263168.1	DEADc_DDX19_DDX25	80..277	CDD:350721	59/202 (29%)
		SF2_C_DEAD	288..414	CDD:350174	44/125 (35%)
Ddx6	NP_031867.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57
		Q motif	96..124		13/27 (48%)
		SrmB	98..461	CDD:440279	119/377 (32%)
		DEAD box	246..249		2/2 (100%)
		Gyf binding. /evidence=ECO:0000250|UniProtKB:P26196	286..316		11/30 (37%)
		RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:P26196	307..483		59/183 (32%)