Protein Alignment vtd and MCD1

DIOPT Version :10

• Sequence 1: NP_001015132.1
• Gene: vtd / 3354896
• FlyBaseID: FBgn0260987
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_010281.1
• Gene: MCD1 / 851561
• SGDID: S000002161
• Length: 566
• Species: Saccharomyces cerevisiae
• Alignment Length: 627
• Identity: 134/627 - (21%)
• Similarity: 232/627 - (37%)
• Gaps: 196/627 - (31%)

  Fly     7 ILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQ---------PKVKLALRTSGHLLLG 62
            :...|||||:||||::. ..|.:..|.:|:|.:|.:.|.:         ....:.|||||.||.|
Yeast    14 LATNKGPLAQIWLASNM-SNIPRGSVIQTHIAESAKEIAKASGCDDESGDNEYITLRTSGELLQG 77

  Fly    63 VVRIYSRKAKYLLADCNEAFVKIKMAFRPG---------MVDLPEGHREANVNAITLPEV----- 113
            :||:||::|.:||.|..:...||.|.|:..         :..:...|:....:|:|..||
Yeast    78 IVRVYSKQATFLLTDIKDTLTKISMLFKTSQKMTSTVNRLNTVTRVHQLMLEDAVTEREVLVTPG 142

  Fly   114 --FHDFDTALP-----ELNDIDIEAQFSINQSRADEITMR----EDYGSLSLS------------ 155
              |.| ||.:|     :.|.::.:.|.:.....:.|:..|    ||:...:||
Yeast   143 LEFLD-DTTIPVGLMAQENSMERKVQGAAPWDTSLEVGRRFSPDEDFEHNNLSSMNLDFDIEEGP 206

  Fly   156 -----------------------LQDDGF-----GDIGFEAETPEIIRCSIPSNINDKIFDND-- 190
                                   :|||.|     |.||::....|         .||:..|:|
Yeast   207 ITSKSWEEGTRQSSRNFDTHENYIQDDDFPLDDAGTIGWDLGITE---------KNDQNNDDDDN 262

  Fly   191 -------VLENIESLDP----HSLDAHADMPGSRLDGDGFGDSFGQPALFEDDLFGDPSQPVEQI 244
                   :.|:|.|.:|    ..||...:.|...:  |...|:..:            |||.:..
Yeast   263 SVEQGRRLGESIMSEEPTDFGFDLDIEKEAPAGNI--DTITDAMTE------------SQPKQTG 313

  Fly   245 TKESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHASVSENVPMN-------- 301
            |:.::.:||......|  :...|..|.|:|  |:.::|:..|.|...       |.|
Yeast   314 TRRNSKLLNTKSIQID--EETENSESIASS--NTYKEERSNNLLTPQ-------PTNFTTKRLWS 367

  Fly   302 EITLVQNEDEGFALAPL--DVSMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLADTSDILTTLDL 364
            |||    |...:...|:  :...|:.:    :|||:......:|...|:...|..|.|:::.
Yeast   368 EIT----ESMSYLPDPILKNFLSYESL----KKRKIHNGREGSIEEPELNVSLNLTDDVISN--- 421

  Fly   365 APPTKRLMYWKETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALEF-Y 428
                                             ...|...|:..|  ::.|..||::....|. :
Yeast   422 ---------------------------------AGTNDNSFNELT--DNMSDFVPIDAGLNEAPF 451

  Fly   429 TKENENALIIFNKKGRKRKNDNMSNLFLDHVPDSVVQS--LEAPEVLR---ANHKSLGVSTVSVE 488
            .:||     |.:.|.|..:. .:....:...|..|...  ::..::||   :..|.:..:.|...
Yeast   452 PEEN-----IIDAKTRNEQT-TIQTEKVRPTPGEVASKAIVQMAKILRKELSEEKEVIFTDVLKS 510

  Fly   489 IVSKEQESISCQNELT--FFD--NMRSPDLLSLNEMEQFSSI 526
            ..:.|.|:|: :.|.:  |||  ::.:...:.|::.|.|.:|
Yeast   511 QANTEPENIT-KREASRGFFDILSLATEGCIGLSQTEAFGNI 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vtd	NP_001015132.1	Rad21_Rec8_N	1..103	CDD:461446	36/113 (32%)
		Rad21_Rec8_M_NXP1-like	327..404	CDD:439294	9/76 (12%)
		Rad21_Rec8	657..710	CDD:335912
MCD1	NP_010281.1	Rad21_Rec8_N	17..108	CDD:461446	35/91 (38%)
		Rad21_Rec8_M_ScScc1p-like	315..394	CDD:439293	20/97 (21%)
		Rad21_Rec8	505..559	CDD:335912	12/48 (25%)