DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vtd and SYN2

DIOPT Version :9

Sequence 1:	NP_001015132.1	Gene:	vtd / 3354896	FlyBaseID:	FBgn0260987	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_568586.2	Gene:	SYN2 / 834084	AraportID:	AT5G40840	Length:	810	Species:	Arabidopsis thaliana

Alignment Length:	871	Identity:	196/871 - (22%)
Similarity:	334/871 - (38%)	Gaps:	234/871 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKV-KLALRTSGHLLLGVV 64
            |||.|.::::||||..||:||::.||:.|:.|..|:|..||:.|||.:: .|..|...:||||||
plant     1 MFYSHCLVSRKGPLGAIWVAAYFFKKLKKSQVKATHIPSSVDQILQKELDALTYRVLAYLLLGVV 65

  Fly    65 RIYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDID- 128
            ||||:|..:|..|||:|.:.:|        :.....|......::||.....|..||||..::|
plant    66 RIYSKKVDFLFDDCNKALIGVK--------EFVAKERNREKTGVSLPASIECFSIALPERFELDA 122

  Fly   129 -----IEAQFSINQSRADEITMRED---------YGSLSLSLQDD-------------------G 160
                 :|.....|....::||:::.         |......:::|                   .
plant   123 FDLGVLEDFHGGNVKPHEDITLKDGSQETERMDMYSMERFDMEEDLLFTFHETFSTNHNENKHES 187

  Fly   161 FG-DIGFEAETPEIIRCSIPSNIND-------KIFDNDVLENIE-SLDPHSLDAHADMPGSRLDG 216
            |. |:..:||           |:.|       ::.:.:.|::.| |.|..:...|.:.|.|
plant   188 FAHDMELDAE-----------NVRDTTEEASVRVVEAEPLDSNEPSRDHQNASRHREDPES---- 237

  Fly   217 DGFGDSFGQPALFEDDLFGDPSQPVEQITKESTTVLNADDSDEDAIDNIH------NVPSPATSL 275
               .|...:|.:.||.........|.:..  .|.|....||.|.:.||:|      |:.|..||.
plant   238 ---DDILLEPQMSEDIRIAQEEDTVRETI--CTIVQRLVDSHESSGDNLHRDGHTENLESEKTSK 297

  Fly   276 VNSIEDEKEENNLNGHASVSENVPMNE-----ITLVQNEDEGFALA------PLDVS----MYKG 325
            ..|.|:.:.:.:|.....:.|.:...|     .|.:..|.|...::      |:.|:    :.:|
plant   298 KTSCEEMQHDRSLPSECGIPEAIHGIEDQPSGATRINGEKEIPEMSTLEKPEPVSVTGSRDLQEG 362

  Fly   326 VTKAK----------------RKRKLIIDEIKNISGEEMKAQLAD------------TSDILTTL 362
            |.|.:                .|.:....|: |:.|.| |..|:|            .:|  |.:
plant   363 VEKCRDHNEAEMADFELFHGSHKEQSETSEV-NLHGSE-KGFLSDMTVSKDPSSEFNATD--TPV 423

  Fly   363 DLAPPTKRLMYWKETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALEF 427
            .:.|.|...:...| ||....||:    ||..|  ...:.::........|...::|.:::
plant   424 TVTPKTPSRLKISE-GGTSPQFSI----IPTPA--AKESSRVSRKRKCLIDDEVIIPNKVM---- 477

  Fly   428 YTKE--NENALIIFNKKG------RKRKNDNMSNLF------LDHVPDSVVQSLEAPEVLRANHK 478
              ||  .:::.::..::.      .:|:....:|.|      |.....|.:|||....:...|..
plant   478 --KEMIEDSSKLLAKRRNVPHTDCPERRTKRFANPFRSFLEPLIQYGSSDLQSLFCQPIKLKNWA 540

  Fly   479 SLGVSTVSVEIVSKEQESISCQNELTFFDNMRSPD-LLSLNEMEQFSSINELP---------LTP 533
            :.|         :.:...|:...|.:..|.:|||. :||.::.|....|.|.|         :|.
plant   541 TTG---------TPKDTKIARHKEKSSLDTVRSPGVILSSDQTENTQEIMETPQAAALAGLKVTA 596

  Fly   534 RNMN---HEMGDDFNQGDSTPAGLDHGHATPQHGNIGE-------MDHDSVIPTKKTAVI----- 583
            .|.|   .|||     ..||.:|..|     |..|..|       :..::.:.|.:..||
plant   597 GNSNVVSVEMG-----ASSTTSGTAH-----QTENAAETPVKPSVIAPETPVRTSEQTVIAPETP 651

  Fly   584 -------------LNESVGTSVLSDNGVSKRTNNILKGWDNY-EIPS-FVGQNH-------GDEQ 626
                         :.||:......|.|...:.:.....:.:: |.|| :..:|.       .|||
plant   652 VVSEQVEIAPETPVRESMSKRFFKDPGTCYKKSRPASPFTSFEEHPSVYYVENRDLDTILMNDEQ 716

  Fly   627 MENETDEQFEERVLNKRAAHLFIDVRAHFIAKDSLE-----------LSQLTSGNSRKQAAQKFY 680
            :..:..:..::...:.|..::     |.|:.|..||           |.||..|.::|::|:.||
plant   717 VNADERQDLQQETWSSRTRNV-----AKFLEKTFLEQREREEEEKVSLLQLCRGRTQKESARLFY 776

  Fly   681 SLLVLKKFKVLHIDQSAPYADITITR 706
            ..||||....:.:.|:.||:|:.:.|
plant   777 ETLVLKTKGYVEVKQNHPYSDVFLMR 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vtd	NP_001015132.1	Rad21_Rec8_N	1..106	CDD:282655	43/105 (41%)
vtd	NP_001015132.1	Rad21_Rec8	657..710	CDD:282654	20/61 (33%)
SYN2	NP_568586.2	Rad21_Rec8_N	1..>87	CDD:282655	41/85 (48%)
SYN2	NP_568586.2	Rad21_Rec8	756..806	CDD:282654	17/47 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	40	1.000	Domainoid score	I4839
eggNOG	1	0.900	-	-		E1_KOG1213
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001363
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12585
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.960